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SGK1 can mediate chemo- and radio-resistance during the treatment of various human tumors, both in vitro and in vivo. (Review)
LEFTY2 (show LEFTY2 ELISA Kits) regulates the expression and activity of ENaC (show SCNN1A ELISA Kits) in endometrial epithelial cells via SGK1.
Up-regulated expression of SGK1 is associated with lung cancer.
Study provides evidence that enhanced SGK expression and activity in multiple myeloma cells contributes to resistance to ER stress, including bortezomib challenge.
data suggest that the induction of SGK1 through treatment with dexamethasone alters MT dynamics to increase Sec5 (show EXOC2 ELISA Kits)-GEF-H1 (show ARHGEF2 ELISA Kits) interactions, which promote GEF-H1 (show ARHGEF2 ELISA Kits) targeting to adhesion sites.
This review focuses on recent advances in understanding of the roles of Akt (show AKT1 ELISA Kits) and SGK1 in the regulation of renal tubular transport.
SGK1 is overexpressed in non-small cell lung cancer.SGK1 positively regulates the growth, migration and metastasis of non-small cell lung cancer.SGK1 activates beta-catenin (show CTNNB1 ELISA Kits) signaling in NSCLC cells.
Data suggest that SGK1 expression is down-regulated in prefrontal cortex neurons of post-traumatic stress disorders subjects (male and female; postmortem samples obtained from tissue bank).
SGK1 plays a pivotal role in vascular inflammation during atherogenesis. SGK1 participates in the regulation of monocyte/macrophage migration and MMP-9 (show MMP9 ELISA Kits) transcription via regulation of nuclear factor-kappaB.
SGK1 was up-regulated in CD4 (show CD4 ELISA Kits) T cells
The data indicate that the balanced activities of two related serine/threonine kinases, AKT (show AKT1 ELISA Kits) and SGK1, critically govern the embryo implantation process.
high levels of resistin (show RETN ELISA Kits) observed during obesity may activate SGK1 in the vasculature and contribute to the development of obesity-related vascular disease
High salt diet may deteriorate lupus nephritis through SGK1 pathway.
Study shows that SGK1 impairs nuclear abundance of p27 (show CDKN1B ELISA Kits) and suggests that phosphorylation of p27T197 by SGK1 is required for cardiac hypertrophy.
SGK1 appears to be an important enzyme in the process of fibrotic remodeling and subsequent weakness of dystrophin (show DMD ELISA Kits)-deficient mouse muscle
The characterisation of SGK1 functions in obesity and immunity may help identify potential therapeutic targets in the treatment of obesity.
Identify SGK1 as a novel powerful regulator of platelet dense granule biogenesis, platelet secretion and thrombus formation. SGK1 is at least partially effective because it regulates transcription of Rab27b (show RAB27B ELISA Kits) in megakaryocytes.
SGK1 inhibits intestinal epithelial cell apoptosis and promotes proliferation via the MEK (show MDK ELISA Kits)/ERK (show EPHB2 ELISA Kits)/p53 (show TP53 ELISA Kits) pathway in colitis.
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Sgk1 variant i3
, serine/threonine protein kinase SGK
, serine/threonine-protein kinase Sgk1
, serum/glucocorticoid-regulated kinase 1
, serum and glucocorticoid-dependent protein kinase
, serum/glucocorticoid regulatory kinase
, serum- and glucocorticoid-induced kinase
, serum and glucocorticoid-regulated protein kinase