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TLR4 (show TLR4 Proteins) and C5aR (show C5AR1 Proteins) crosstalk in dendritic cells induces a core regulatory network of RSK2 (show RPS6KA3 Proteins), PI3Kbeta, SGK1, and FOXO (show FOXO3 Proteins) transcription factors.
Findings illustrate how cancer cells utilize a chromatin remodeling factor (show ASH1L Proteins) to engage a core survival pathway to support its cancerous phenotypes, and reveal new facets of MTA1 (show MTA1 Proteins)-SGK1 axis by a physiologic signal in cancer progression.
SGK1 inhibitor SI113 induced a significant reduction in endometrial cancer cells viability, as a result of induction of autophagy, apoptosis, and endoplasmic reticulum stress.
Findings show that serum and glucocorticoid-inducible kinase 1 (SGK1) protein dynamics can be an important part of intracellular signaling, directly influencing cellular response decisions.
In cancer cells resistant to PI3Kalpha inhibition, PDK1 blockade restores sensitivity to these therapies. SGK1, which is activated by PDK1, contributes to the maintenance of residual mTORC1 activity through direct phosphorylation and inhibition of TSC2.
SGK1 promotes YAP/TAZ transcriptional activity. SGK1 enhances YAP/TAZ activity by upregulating YAP/TAZ. SGK1 is a transcriptional target of YAP. SGK1 stabilizes TAZ by inhibiting GSK3beta.
Potassium supplementation has a blocking effect against salt-loading-induced IL-17A (show IL17A Proteins) production in T lymphocytes, and the protective effect was mediated through suppression of p38/MAPK (show MAPK14 Proteins)-SGK1 pathway.
Akt3 (show AKT3 Proteins) constitutively suppresses macropinocytosis in macrophages through a novel WNK1 (show WNK1 Proteins)/SGK1/Cdc42 (show CDC42 Proteins) pathway.
Increased expression of SGK1 is associated with Hydrosalpinx.
Human SMCT1 is regulated by insulin (show INS Proteins) and SGK1.
Altered K balance in animals lacking SGK1 may reflect defects in epithelial Na channel -independent K excretion
our data suggest that renal tubular SGK1 is important in the regulation of K(+) excretion via the control of NEDD4-2 (show NEDD4L Proteins), WNK1 (show WNK1 Proteins), and ENaC (show SCNN1A Proteins)
SGK1 is similarly involved in the regulation of cell volume and cell fluid transport.
Mineralocorticoid receptor (show NR3C2 Proteins) deficiency suppresses migration and proliferation of macrophages and leads to less vascular smooth muscle cell activation. At the molecular level, MR deficiency suppresses macrophage inflammatory response via SGK1-AP1 (show JUN Proteins)/NF-kappaB (show NFKB1 Proteins) pathways.
SGK1 and SGK3 (show SGK3 Proteins) are expressed in multiple microglial cell lines. SGK1 and SGK3 (show SGK3 Proteins) may play an important role in regulating microglial viability and inflammatory responses.
The data indicate that the balanced activities of two related serine/threonine kinases, AKT (show AKT1 Proteins) and SGK1, critically govern the embryo implantation process.
LEFTY2 (show LEFTY2 Proteins) regulates the expression and activity of ENaC (show SCNN1A Proteins) in endometrial epithelial cells via SGK1.
high levels of resistin (show RETN Proteins) observed during obesity may activate SGK1 in the vasculature and contribute to the development of obesity-related vascular disease
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Sgk1 variant i3
, serine/threonine protein kinase SGK
, serine/threonine-protein kinase Sgk1
, serum/glucocorticoid-regulated kinase 1
, serum and glucocorticoid-dependent protein kinase
, serum/glucocorticoid regulatory kinase
, serum- and glucocorticoid-induced kinase
, serum and glucocorticoid-regulated protein kinase