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Human SGK1 Protein expressed in Escherichia coli (E. coli) - ABIN667573
Maiyar, Huang, Phu, Cha, Firestone: p53 stimulates promoter activity of the sgk. serum/glucocorticoid-inducible serine/threonine protein kinase gene in rodent mammary epithelial cells. in The Journal of biological chemistry 1996
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Potassium supplementation has a blocking effect against salt-loading-induced IL-17A (show IL17A Proteins) production in T lymphocytes, and the protective effect was mediated through suppression of p38/MAPK (show MAPK14 Proteins)-SGK1 pathway.
Akt3 (show AKT3 Proteins) constitutively suppresses macropinocytosis in macrophages through a novel WNK1 (show WNK1 Proteins)/SGK1/Cdc42 (show CDC42 Proteins) pathway.
Increased expression of SGK1 is associated with Hydrosalpinx.
Human SMCT1 is regulated by insulin (show INS Proteins) and SGK1.
SGK1 overexpression in tissues and serum was found in patients with endometriosis.
SGK1 can mediate chemo- and radio-resistance during the treatment of various human tumors, both in vitro and in vivo. (Review)
LEFTY2 (show LEFTY2 Proteins) regulates the expression and activity of ENaC (show SCNN1A Proteins) in endometrial epithelial cells via SGK1.
Up-regulated expression of SGK1 is associated with lung cancer.
Study provides evidence that enhanced SGK expression and activity in multiple myeloma cells contributes to resistance to ER stress, including bortezomib challenge.
data suggest that the induction of SGK1 through treatment with dexamethasone alters MT dynamics to increase Sec5-GEF-H1 (show ARHGEF2 Proteins) interactions, which promote GEF-H1 (show ARHGEF2 Proteins) targeting to adhesion sites.
SGK1 is similarly involved in the regulation of cell volume and cell fluid transport.
Mineralocorticoid receptor (show NR3C2 Proteins) deficiency suppresses migration and proliferation of macrophages and leads to less vascular smooth muscle cell activation. At the molecular level, MR deficiency suppresses macrophage inflammatory response via SGK1-AP1 (show JUN Proteins)/NF-kappaB (show NFKB1 Proteins) pathways.
SGK1 and SGK3 (show SGK3 Proteins) are expressed in multiple microglial cell lines. SGK1 and SGK3 (show SGK3 Proteins) may play an important role in regulating microglial viability and inflammatory responses.
The data indicate that the balanced activities of two related serine/threonine kinases, AKT (show AKT1 Proteins) and SGK1, critically govern the embryo implantation process.
high levels of resistin (show RETN Proteins) observed during obesity may activate SGK1 in the vasculature and contribute to the development of obesity-related vascular disease
High salt diet may deteriorate lupus nephritis through SGK1 pathway.
Study shows that SGK1 impairs nuclear abundance of p27 (show CDKN1B Proteins) and suggests that phosphorylation of p27T197 by SGK1 is required for cardiac hypertrophy.
SGK1 appears to be an important enzyme in the process of fibrotic remodeling and subsequent weakness of dystrophin (show DMD Proteins)-deficient mouse muscle
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Sgk1 variant i3
, serine/threonine protein kinase SGK
, serine/threonine-protein kinase Sgk1
, serum/glucocorticoid-regulated kinase 1
, serum and glucocorticoid-dependent protein kinase
, serum/glucocorticoid regulatory kinase
, serum- and glucocorticoid-induced kinase
, serum and glucocorticoid-regulated protein kinase