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Human SGK1 Protein expressed in Escherichia coli (E. coli) - ABIN667573
Maiyar, Huang, Phu, Cha, Firestone: p53 stimulates promoter activity of the sgk. serum/glucocorticoid-inducible serine/threonine protein kinase gene in rodent mammary epithelial cells. in The Journal of biological chemistry 1996
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data suggest that the induction of SGK1 through treatment with dexamethasone alters MT dynamics to increase Sec5-GEF-H1 (show ARHGEF2 Proteins) interactions, which promote GEF-H1 (show ARHGEF2 Proteins) targeting to adhesion sites.
This review focuses on recent advances in understanding of the roles of Akt (show AKT1 Proteins) and SGK1 in the regulation of renal tubular transport.
SGK1 is overexpressed in non-small cell lung cancer.SGK1 positively regulates the growth, migration and metastasis of non-small cell lung cancer.SGK1 activates beta-catenin (show CTNNB1 Proteins) signaling in NSCLC cells.
Data suggest that SGK1 expression is down-regulated in prefrontal cortex neurons of post-traumatic stress disorders subjects (male and female; postmortem samples obtained from tissue bank).
SGK1 plays a pivotal role in vascular inflammation during atherogenesis. SGK1 participates in the regulation of monocyte/macrophage migration and MMP-9 (show MMP9 Proteins) transcription via regulation of nuclear factor-kappaB.
SGK1 was up-regulated in CD4 (show CD4 Proteins) T cells
SGK1 inhibits intestinal epithelial cell apoptosis and promotes proliferation via the MEK (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins)/p53 (show TP53 Proteins) pathway in colitis.
Increased SGK-1 expression reduces oxidative stress and improves cell survival in endothelial cells.
These findings have identified an anti-inflammatory function of SGK1, elucidated the underlying intracellular mechanisms
FE65 (show APBB1 Proteins) influences APP (show APP Proteins) degradation via the proteasome, and phosphorylation of FE65 (show APBB1 Proteins) Ser (show SIGLEC1 Proteins)(610) by SGK1 regulates binding of FE65 (show APBB1 Proteins) to APP (show APP Proteins), APP (show APP Proteins) turnover and processing.
High salt diet may deteriorate lupus nephritis through SGK1 pathway.
Study shows that SGK1 impairs nuclear abundance of p27 (show CDKN1B Proteins) and suggests that phosphorylation of p27T197 by SGK1 is required for cardiac hypertrophy.
SGK1 appears to be an important enzyme in the process of fibrotic remodeling and subsequent weakness of dystrophin (show DMD Proteins)-deficient mouse muscle
The characterisation of SGK1 functions in obesity and immunity may help identify potential therapeutic targets in the treatment of obesity.
Identify SGK1 as a novel powerful regulator of platelet dense granule biogenesis, platelet secretion and thrombus formation. SGK1 is at least partially effective because it regulates transcription of Rab27b (show RAB27B Proteins) in megakaryocytes.
SGK1 inhibits intestinal epithelial cell apoptosis and promotes proliferation via the MEK (show MDK Proteins)/ERK (show EPHB2 Proteins)/p53 (show TP53 Proteins) pathway in colitis.
measured gene expression of Fos, Per1 and Sgk1 45 min after exposure to brief cold swim stress in male and female mice; Sgk1 was insensitive to handling, and increased in response to stress similarly in males and females
17beta-estradiol attenuates LPS (show TLR4 Proteins)-induced acute lung injury via PI3K/Akt (show AKT1 Proteins)/SGK1 mediated up-regulation of Scnn1a (show SCNN1A Proteins).
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Sgk1 variant i3
, serine/threonine protein kinase SGK
, serine/threonine-protein kinase Sgk1
, serum/glucocorticoid-regulated kinase 1
, serum and glucocorticoid-dependent protein kinase
, serum/glucocorticoid regulatory kinase
, serum- and glucocorticoid-induced kinase
, serum and glucocorticoid-regulated protein kinase