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anti-Human SIRT1 antibody for Immunofluorescence

Recommended SIRT1 Antibody (supplied by: Log in to see )

Antigen
Sirtuin 1 (SIRT1) Antibodies
  • AA673258
  • SIR2
  • Sir2
  • Sir2a
  • Sir2alpha
  • SIR2L1
  • sir2l1
  • sirtuin
  • sirtuin 1
Reactivity
Human, Monkey
252
104
46
8
7
6
4
4
3
3
2
2
2
2
1
1
Host
Mouse
183
56
25
7
2
Clonality
Monoclonal
Conjugate
This SIRT1 antibody is un-conjugated
14
12
9
5
5
4
3
3
3
3
3
3
3
3
3
3
3
3
2
2
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
212
112
57
41
40
34
28
25
10
5
4
4
3
2
1
1
Supplier
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Catalog No. ABIN1109014
$ 390.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.32215732 ABIN565071 IF IHC (p) ELISA WB Mouse IgG1 kappa AA 456-555, partial Log in to see 7B7 3
0.32215732 ABIN614713 EIA IF IHC (p) WB Mouse IgG1 AA 456-555 Log in to see 7B7
0.32215732 ABIN1031567 IF ELISA WB Chicken N-Term Log in to see Polyclonal
0.32215732 ABIN2403466 ChIP IF IP IHC WB Rabbit IgG Log in to see Polyclonal
0.32215732 ABIN2505456 IF ELISA WB Chicken N-Term Log in to see Polyclonal
0.001082034 ABIN2668278 ICC IF IP WB Mouse IgG1 AA 581-630 Log in to see 2G1-F7 2
0.001082034 ABIN258470 ICC IHC (fro) IF IHC (p) IP IHC WB Rabbit IgG C-Term Log in to see E104
0.001082034 ABIN1500927 ICC FACS IF IHC ELISA WB Mouse IgG1 Log in to see 1F3
0.001082034 ABIN396774 IF WB Mouse IgG1 kappa AA 456-555 Log in to see 7B7
0.001082034 ABIN1723581 IF IHC (p) ELISA WB Mouse IgG1 kappa AA 456-555 Log in to see 7B7
0.001082034 ABIN445114 ICC IF IHC (p) IHC WB Rabbit IgG Ser47 Log in to see EPR2849Y
0.001082034 ABIN2471078 IF IHC ELISA WB Mouse IgG1 kappa AA 456-555 Log in to see 7B7
0.001082034 ABIN574445 IF IHC (p) ELISA WB Mouse IgG1, kappa Log in to see 7B7
0.001082034 ABIN3198318 ChIP IC IF IHC IP WB Rabbit Log in to see Polyclonal
0.001082034 ABIN2476505 IF IHC (p) WB Mouse IgG1 AA 456-555 Log in to see 7B7
0.001082034 ABIN574544 IF ELISA WB Chicken N-Term Log in to see Polyclonal
0.001082034 ABIN2878490 IF Rabbit IgG Log in to see Polyclonal
0.001082034 ABIN2412702 IF WB Mouse IgG1 kappa AA 456-555 Log in to see 11C756
0.001082034 ABIN1583528 IF IHC WB Mouse IgG1 Log in to see 1F3
0.001082034 ABIN1888121 IF ELISA WB Rabbit N-Term Log in to see Polyclonal

Top referenced anti-SIRT1 antibody for Immunofluorescence

Similar anti-SIRT1 Antibodies

Application / Reactivity Monkey Human
ELISA 6 Antibodies 95 Antibodies
Enzyme Immunoassay (EIA) 1 Antibodies 4 Antibodies
Flow Cytometry (FACS) 4 Antibodies 11 Antibodies
Immunocytochemistry (ICC) 2 Antibodies 27 Antibodies
Immunofluorescence (IF) 4 Antibodies 43 Antibodies
Immunohistochemistry (IHC) 4 Antibodies 58 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 2 Antibodies 40 Antibodies
Western Blotting (WB) 8 Antibodies
Chromatin Immunoprecipitation (ChIP) 4 Antibodies
ELISA (Capture) 1 Antibodies
Immunochromatography (IC) 2 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 34 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 3 Antibodies

General

Antigen Sirtuin 1 (SIRT1) Antibodies
Reactivity Human, Monkey
(252), (104), (46), (8), (7), (6), (4), (4), (3), (3), (2), (2), (2), (2), (1), (1)
Host Mouse
(183), (56), (25), (7), (2)
Clonality (Clone)
Monoclonal   ( )
Conjugate This SIRT1 antibody is un-conjugated
(14), (12), (9), (5), (5), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(212), (112), (57), (41), (40), (34), (28), (25), (10), (5), (4), (4), (3), (2), (1), (1)
Pubmed 2 references available
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Product Details anti-SIRT1 Antibody

Target Details SIRT1 Application Details Handling References for anti-SIRT1 Antibody (ABIN1109014) Images
Specificity Recognizes SIRT1
Cross-Reactivity (Details) Species reactivity (tested):Human, Monkey.
Purification Ascites
Clone 1F3
Isotype IgG1

Target Details SIRT1

Product Details anti-SIRT1 Antibody Application Details Handling References for anti-SIRT1 Antibody (ABIN1109014) Images back to top
Antigen
Alternative Name SIRT1 (SIRT1 Antibody Abstract)
Background The Sir2 protein in yeast is known to function in transcriptional silencing processes through the deacetylation of histones H3 and H4. The more recently described human homologue of Sir2, known as SIRT1, has been found to associate with the tumor suppressor protein p53.SIRT1 binds and deacetylates p53 with specificity for its C-terminal Lys382 residue in response to the upregulation of promyelocytic leukemia protein (PML) nuclear bodies or oncogenic Ras. The deacetylation of p53 SIRT1 has been shown to negatively regulate p53-mediated transcription, preventing cellular senescence and apoptosis induced by DNA damage and stress.SIRT1 has the closest homology to the yeast Sir2p and is widely expressed in fetal and adult tissues, with high expression in heart, brain and skeletal muscle and low expression in lung and placenta. SIRT1 regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53, specifically at Lysine 382.Synonyms: NAD-dependent deacetylase sirtuin-1, S. cerevisiae, SIR2-like protein 1, SIR2L1, SIR2alpha, SIRT-1, homolog) 1, sirtuin (silent mating type information regulation 2, sirtuin 1, sirtuin type 1, sirtuin-1
Molecular Weight 120 kDa
Gene ID 23411
Research Area Chromatin and Nuclear Signaling, Apoptosis/Necrosis, Proteases
Pathways MAPK Signaling

Application Details

Product Details anti-SIRT1 Antibody Target Details SIRT1 Handling References for anti-SIRT1 Antibody (ABIN1109014) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-SIRT1 Antibody Target Details SIRT1 Application Details References for anti-SIRT1 Antibody (ABIN1109014) Images back to top
Format Liquid

References for anti-SIRT1 Antibody (ABIN1109014)

Product Details anti-SIRT1 Antibody Target Details SIRT1 Application Details Handling Images back to top
Background publications

Sowa, Bennett, Gygi, Harper: "Defining the human deubiquitinating enzyme interaction landscape." in: Cell, Vol. 138, Issue 2, pp. 389-403, 2009

Xie, Park, Kim, Hwang, Oh, Park, Shong, Lee, Choi: "Transcriptional corepressor SMILE recruits SIRT1 to inhibit nuclear receptor estrogen receptor-related receptor gamma transactivation." in: The Journal of biological chemistry, Vol. 284, Issue 42, pp. 28762-74, 2009

Images

Product Details anti-SIRT1 Antibody Target Details SIRT1 Application Details Handling References for anti-SIRT1 Antibody (ABIN1109014) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-SIRT1 antibody (Sirtuin 1) (ABIN1109014) anti-Sirtuin 1 (SIRT1) antibody
Western Blotting (WB) image for anti-SIRT1 antibody (Sirtuin 1) (ABIN1109014) anti-Sirtuin 1 (SIRT1) antibody (Image 2)
Immunohistochemistry (IHC) image for anti-SIRT1 antibody (Sirtuin 1) (ABIN1109014) anti-Sirtuin 1 (SIRT1) antibody (Image 3)
Immunofluorescence (IF) image for anti-SIRT1 antibody (Sirtuin 1) (ABIN1109014) anti-Sirtuin 1 (SIRT1) antibody (Image 4)