You are viewing an incomplete version of our website. Please click to reload the website as full version.

anti-Rat (Rattus) SIRT1 antibody for Immunohistochemistry

Recommended SIRT1 Antibody (supplied by: Log in to see )

Antigen
Sirtuin 1 (SIRT1) Antibodies
  • AA673258
  • SIR2
  • Sir2
  • Sir2a
  • Sir2alpha
  • SIR2L1
  • sir2l1
  • sirtuin
  • sirtuin 1
Reactivity
Human, Rat (Rattus)
252
104
45
8
8
6
4
4
3
3
2
2
2
2
1
1
Host
Rabbit
182
57
25
7
2
Clonality
Polyclonal
Conjugate
This SIRT1 antibody is un-conjugated
14
12
9
5
5
4
3
3
3
3
3
3
3
3
3
3
3
3
2
2
1
1
1
1
1
1
1
Application
Chromatin Immunoprecipitation (ChIP), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
212
112
56
41
41
34
28
24
11
5
4
4
3
2
1
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Available images

Catalog No. ABIN2403466
$ 588.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0011326512 ABIN1525672 IHC WB Rabbit IgG C-Term Log in to see Polyclonal
0.0011326512 ABIN3020731 IHC WB Rabbit IgG C-Term Log in to see Polyclonal
0.0011326512 ABIN3198318 ChIP IC IF IHC IP WB Rabbit Log in to see Polyclonal
0.0011326512 ABIN4353900 ELISA FACS ICC IF IHC IHC (p) WB Mouse IgG1 Log in to see 1F3
0.0011326512 ABIN4353901 ELISA FACS ICC IF IHC IHC (p) WB Mouse IgG1 Log in to see 1F3
0.0011326512 ABIN2988487 ChIP ICC IF IP IHC WB Rabbit IgG C-Term Log in to see Polyclonal
0.0011326512 ABIN2984582 IP IHC WB Rabbit IgG Log in to see Polyclonal

Similar anti-SIRT1 Antibodies

Application / Reactivity Rat (Rattus) Human
Chromatin Immunoprecipitation (ChIP) 3 Antibodies 4 Antibodies
ELISA 18 Antibodies 95 Antibodies
Enzyme Immunoassay (EIA) 1 Antibodies 4 Antibodies
Immunocytochemistry (ICC) 5 Antibodies 27 Antibodies
Immunofluorescence (IF) 11 Antibodies 43 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies
Immunohistochemistry (IHC) 8 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 1 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 6 Antibodies
Immunoprecipitation (IP) 5 Antibodies
Western Blotting (WB) 33 Antibodies
ELISA (Capture) 1 Antibodies
Flow Cytometry (FACS) 11 Antibodies
Immunochromatography (IC) 2 Antibodies

General

Antigen Sirtuin 1 (SIRT1) Antibodies
Reactivity Human, Rat (Rattus)
(252), (104), (45), (8), (8), (6), (4), (4), (3), (3), (2), (2), (2), (2), (1), (1)
Host Rabbit
(182), (57), (25), (7), (2)
Clonality
Polyclonal
Conjugate This SIRT1 antibody is un-conjugated
(14), (12), (9), (5), (5), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Application Chromatin Immunoprecipitation (ChIP), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
(212), (112), (56), (41), (41), (34), (28), (24), (11), (5), (4), (4), (3), (2), (1), (1)
Supplier Log in to see

Product Details anti-SIRT1 Antibody

Target Details SIRT1 Application Details Handling Images
Purification Antigen affinity purification
Immunogen C term -peptide of human SIRT1
Isotype IgG

Target Details SIRT1

Product Details anti-SIRT1 Antibody Application Details Handling Images back to top
Antigen
Alternative Name SIRT1 (SIRT1 Antibody Abstract)
Background The Silent Information Regulator (SIR2) family of genes is a highly conserved group of genes that encode nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases, also known as class III histone deacetylases. The first discovered and best characterized of these genes is Saccharomyces cerevisiae SIR2, which is involved in silencing of mating type loci, telomere maintenance, DNA damage response, and cell aging (1). SirT1, the mammalian ortholog of Sir2, is a nuclear protein implicated in the regulation of many cellular processes, including apoptosis, cellular senescence, endocrine signaling, glucose homeostasis, aging, and longevity. Targets of SirT1 include acetylated p53 (2,3), p300 (4), Ku70 (5), forkhead (FoxO) transcription factors (5,6), PPARγ (7), and the PPARγ coactivator-1α (PGC-1α) protein (8). Deacetylation of p53 and FoxO transcription factors represses apoptosis and increases cell survival (2,3,5,6). Deacetylation of PPARγ and PGC-1α regulates the gluconeogenic/glycolytic pathways in the liver and fat mobilization in white adipocytes in response to fasting (7,8). SirT1 deacetylase activity is inhibited by nicotinamide and activated by resveratrol. In addition, SirT1 activity may be regulated by phosphorylation, since it is phosphorylated on Ser27 and Ser47 in vivo, however, the function of these phosphorylation sites has not yet been determined (9).
Synonyms: SIRT1,SIR2L1 ,
Molecular Weight Observed MW: 82kDa
Research Area Chromatin and Nuclear Signaling, Apoptosis/Necrosis, Proteases
Pathways MAPK Signaling

Application Details

Product Details anti-SIRT1 Antibody Target Details SIRT1 Handling Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-SIRT1 Antibody Target Details SIRT1 Application Details Images back to top
Format Liquid
Handling Advice Avoid freeze / thaw cycles.
Storage -20 °C/-80 °C
Storage Comment Store at -20°C (regular) and -80°C (long term).

Images

Product Details anti-SIRT1 Antibody Target Details SIRT1 Application Details Handling back to top
Supplier Images
Immunofluorescence (IF) image for anti-SIRT1 antibody (Sirtuin 1) (ABIN2403466) Immunofluorescence analysis analysis of A549 cell using SIRT1 antibody. Blue: DAPI fo...
Immunohistochemistry (IHC) image for anti-SIRT1 antibody (Sirtuin 1) (ABIN2403466) Immunohistochemistry of paraffin-embedded human brain cancer using SIRT1 antibody at ...
Immunohistochemistry (IHC) image for anti-SIRT1 antibody (Sirtuin 1) (ABIN2403466) Immunohistochemistry of paraffin-embedded rat brain using SIRT1 antibody at dilution ...
Western Blotting (WB) image for anti-SIRT1 antibody (Sirtuin 1) (ABIN2403466) Western blot analysis of extracts of various cell lines, using SIRT1 antibody.