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anti-Mouse (Murine) HSD17B3 Antibodies:
anti-Rat (Rattus) HSD17B3 Antibodies:
anti-Human HSD17B3 Antibodies:
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Human Polyclonal HSD17B3 Primary Antibody for ELISA, WB - ABIN561372
Locke, Guns, Lubik, Adomat, Hendy, Wood, Ettinger, Gleave, Nelson: Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer. in Cancer research 2008
Show all 3 Pubmed References
Horse (Equine) Polyclonal HSD17B3 Primary Antibody for WB - ABIN2785439
Bertin, Dury, Ouellet, Pelletier, Labrie: Localization of the androgen-synthesizing enzymes, androgen receptor, and sex steroids in the vagina: possible implications for the treatment of postmenopausal sexual dysfunction. in The journal of sexual medicine 2014
High 4-tert (show TERT Antibodies)-Octylphenol doses affect the cytoarchitecture of MA-10 Leydig cells as well as attenuate 3beta-HSD (show HAL Antibodies) and AR expression.
Pubertal Cd exposure markedly reduced mRNA and protein levels of testicular StAR, P450scc (show CYP11A1 Antibodies), P450 (show POR Antibodies)(17alpha) and 17beta-HSD (show HSD17B1 Antibodies) in mice.
The study shows that 17-beta-HSD-3 deficiency is not an uncommon disorder among Egyptian DSD (show FADS1 Antibodies) cases. It was evidenced that the mutational profile of the disease is rather heterogeneous, relatively different from those reported in other populations, and has a high degree of novel genetic defects.
analysis of Tunisian patients with mutations in the gene encoding 17beta-hydroxysteroid dehydrogenase (show HSD17B7 Antibodies) type 3 and a founder effect
Mutation G133R in HSD17B3 results in almost complete loss of enzyme activity since it interferes with binding of cofactor NADPH.
Mutations in the HSD17B3 gene is associated with Disorders of Sex Development.
Expression of the genes HSD3B1 (show HSD3B1 Antibodies), HSD17B3, and SRD5A2 (show SRD5A2 Antibodies) was significantly increased in BPH (show GLI3 Antibodies) tissues compared to normal adjacent prostate tissues.
Missense mutation in HSD17B3 gene in a 46, XY adolescent is associated with primary amenorrhea and virilization at puberty
38% of unrelated 46,XY females with unknown diagnosis in the study have HSD17B3 mutations predicted to cause HSD17B3 deficiency.
These results suggest that the HSD17B3 G289S polymorphism may be a potential risk modifier for hypospadias.
68 males with testicular 17beta-HSD deficiency were identified among a highly inbred Arab population in Israel as affected with male pseudohermaphroditism. [Review]
This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia.
17(beta)HSD type 3
, 17-beta-HSD 3
, 17-beta-hydroxysteroid dehydrogenase type 3
, testicular 17-beta-hydroxysteroid dehydrogenase
, testosterone 17-beta-dehydrogenase 3
, estradiol 17 beta-dehydrogenase 3
, short chain dehydrogenase/reductase family 12C, member 2