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Human Monoclonal SRD5A2 Primary Antibody for ELISA, WB - ABIN520465
Sato, Iemitsu, Matsutani, Kurihara, Hamaoka, Fujita: Resistance training restores muscle sex steroid hormone steroidogenesis in older men. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014
Human Polyclonal SRD5A2 Primary Antibody for ELISA, WB - ABIN562991
Park, Aizawa, Iemitsu, Sato, Akimoto, Agata, Maeda, Ezawa, Omi: DHEA administration activates local bioactive androgen metabolism in cancellous site of tibia of ovariectomized rats. in Calcified tissue international 2011
Human Polyclonal SRD5A2 Primary Antibody for IHC, WB - ABIN2781788
Bertin, Dury, Ouellet, Pelletier, Labrie: Localization of the androgen-synthesizing enzymes, androgen receptor, and sex steroids in the vagina: possible implications for the treatment of postmenopausal sexual dysfunction. in The journal of sexual medicine 2014
Human Polyclonal SRD5A2 Primary Antibody for ELISA - ABIN268809
Iczkowski, Qiu, Qian, Somerville, Rittmaster, Andriole, Bostwick: The dual 5-alpha-reductase inhibitor dutasteride induces atrophic changes and decreases relative cancer volume in human prostate. in Urology 2005
Human Polyclonal SRD5A2 Primary Antibody for ELISA, WB - ABIN451821
Torkko, van Bokhoven, Mai, Beuten, Balic, Byers, Hokanson, Norris, Barón, Lucia, Thompson, Leach: VDR and SRD5A2 polymorphisms combine to increase risk for prostate cancer in both non-Hispanic White and Hispanic White men. in Clinical cancer research : an official journal of the American Association for Cancer Research 2008
Prostate 5aR1 levels were positively correlated with adjusted prostate most severe lesion scores. Downregulation of androgen receptor (show AR Antibodies) and 5alpha-reductase 2, along with upregulation of 5a-reductase 1 in tumors may promote prostatic intraepithelial neoplasia and prostate cancer development in TRAMP (show DPT Antibodies) mice
observed an abnormally high expression levels of type 2 5alpha-reductase and 20alpha-HSD in the male and female adrenals, respectively, thus indirectly suggesting new roles for these sex-specific enzymes
The induction of Srd5a2 through SREBP-2 (show SREBF2 Antibodies) provides a mechanistic explanation for why even though statin therapy is effective in reducing cholesterol levels in treating hypercholesterolemia it does not compromise androgen production in clinical studies.
Findings suggest that 5alpha-reductases (5-AR) isoenzymes could be explored as a therapeutic target for urothelial bladder cancer (UBC (show RPS27A Antibodies)) with 5alpha-reductase inhibitors (5-ARI (show ARIH1 Antibodies)).
Lack of SRD5A2 expression in the prostate induces an androgenic to oestrogenic switch in human benign prostatic tissues.
deficiency of 5-alpha reductase type 2 was considered and SRD5A2 was sequenced. This identified homozygous pathogenic variants in SRD5A2 (p. Pro212Arg), which confirmed a diagnosis of deficiency of 5-alpha reductase type 2
Chromosomal anomalies and mutations of the SRD5A2 gene are associated with hypospadias.
Polymorphism in the SRD5A2 gene is associated with hypospadias.
In a recent study we reported associations between ALTs and single nucleotide polymorphisms (SNPs) in the genes encoding estrogen receptor 1 (ESR1 (show ESR1 Antibodies)), steroid-5-alpha-reductase, type 2 (SRD5A2) and sex hormone-binding globulin (SHBG (show SHBG Antibodies)). No associations between the previously associated SNPs in the genes ESR1 (show ESR1 Antibodies) and SRD5A2 and autistic-like traits could be seen in the large replication sample.
Studies indicate that enhanced 5alpha-reductase activity in subjects with polycystic ovary syndrome (PCOS) was associated with insulin (show INS Antibodies) resistance (IR) rather than obesity.
Mutations in the SRD5A2 cause a disorder of 46,XY sex development, termed 5alpha-reductase type 2 deficiency. (Review)
Meta-analysis of 20 publications incorporating 30 case-control studies indicated that the SRD5A2 rs9282858 polymorphism may be a susceptible factor to prostate cancer.
Although 4-dione is the main source of 5alpha-dihydrotestosterone in human preadipocytes, production of this steroid by 5 alpha-reductase isoenzymes (SRD5A1 (show SRD5A1 Antibodies), 2 and 3) mediates the inhibitory effect of both 4-dione and testosterone on preadipocyte differentiation.
This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH).
3-oxo-5-alpha-steroid 4-dehydrogenase 2
, steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
, steroid-5-alpha-reductase alpha polypeptide 2
, 5 alpha-SR2
, SR type 2
, steroid 5 alpha reductase type2
, steroid 5-alpha-reductase 2
, S5AR 2
, type II 5-alpha reductase
, prostatic steroid 5-alpha-reductase type II