Browse our anti-Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2) Antibodies

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anti-Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) Antibodies (SRD5A2)
On www.antibodies-online.com are 70 Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2) Antibodies from 12 different suppliers available. Additionally we are shipping Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) Kits (22) and Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) Proteins (4) and many more products for this protein. A total of 102 Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) products are currently listed.
Synonyms:
5ART2, S5AR 2, Srd5a2, SRD5alpha2
list all antibodies Gene Name GeneID UniProt
SRD5A2 94224 Q99N99
SRD5A2 6716 P31213
SRD5A2 64677 P31214

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Most Popular Reactivities for anti-Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2) Antibodies

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All available anti-Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) Antibodies

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Top referenced anti-Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) Antibodies

  1. Human Monoclonal SRD5A2 Primary Antibody for ELISA, WB - ABIN520465 : Sato, Iemitsu, Matsutani, Kurihara, Hamaoka, Fujita: Resistance training restores muscle sex steroid hormone steroidogenesis in older men. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 (PubMed)

  2. Human Polyclonal SRD5A2 Primary Antibody for ELISA, WB - ABIN562991 : Park, Aizawa, Iemitsu, Sato, Akimoto, Agata, Maeda, Ezawa, Omi: DHEA administration activates local bioactive androgen metabolism in cancellous site of tibia of ovariectomized rats. in Calcified tissue international 2011 (PubMed)

  3. Human Polyclonal SRD5A2 Primary Antibody for IHC, WB - ABIN2781788 : Bertin, Dury, Ouellet, Pelletier, Labrie: Localization of the androgen-synthesizing enzymes, androgen receptor, and sex steroids in the vagina: possible implications for the treatment of postmenopausal sexual dysfunction. in The journal of sexual medicine 2014 (PubMed)

  4. Human Polyclonal SRD5A2 Primary Antibody for ELISA - ABIN268809 : Iczkowski, Qiu, Qian, Somerville, Rittmaster, Andriole, Bostwick: The dual 5-alpha-reductase inhibitor dutasteride induces atrophic changes and decreases relative cancer volume in human prostate. in Urology 2005 (PubMed)

  5. Human Polyclonal SRD5A2 Primary Antibody for ELISA, WB - ABIN451821 : Torkko, van Bokhoven, Mai, Beuten, Balic, Byers, Hokanson, Norris, Barón, Lucia, Thompson, Leach: VDR and SRD5A2 polymorphisms combine to increase risk for prostate cancer in both non-Hispanic White and Hispanic White men. in Clinical cancer research : an official journal of the American Association for Cancer Research 2008 (PubMed)

More Antibodies against Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) Interaction Partners

Mouse (Murine) Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2) interaction partners

  1. Prostate 5aR1 levels were positively correlated with adjusted prostate most severe lesion scores. Downregulation of androgen receptor (show AR Antibodies) and 5alpha-reductase 2, along with upregulation of 5a-reductase 1 in tumors may promote prostatic intraepithelial neoplasia and prostate cancer development in TRAMP (show DPT Antibodies) mice

  2. observed an abnormally high expression levels of type 2 5alpha-reductase and 20alpha-HSD in the male and female adrenals, respectively, thus indirectly suggesting new roles for these sex-specific enzymes

  3. The induction of Srd5a2 through SREBP-2 (show SREBF2 Antibodies) provides a mechanistic explanation for why even though statin therapy is effective in reducing cholesterol levels in treating hypercholesterolemia it does not compromise androgen production in clinical studies.

Human Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2) interaction partners

  1. Chromosomal anomalies and mutations of the SRD5A2 gene are associated with hypospadias.

  2. Polymorphism in the SRD5A2 gene is associated with hypospadias.

  3. In a recent study we reported associations between ALTs and single nucleotide polymorphisms (SNPs) in the genes encoding estrogen receptor 1 (ESR1 (show ESR1 Antibodies)), steroid-5-alpha-reductase, type 2 (SRD5A2) and sex hormone-binding globulin (SHBG (show SHBG Antibodies)). No associations between the previously associated SNPs in the genes ESR1 (show ESR1 Antibodies) and SRD5A2 and autistic-like traits could be seen in the large replication sample.

  4. Studies indicate that enhanced 5alpha-reductase activity in subjects with polycystic ovary syndrome (PCOS) was associated with insulin (show INS Antibodies) resistance (IR) rather than obesity.

  5. Mutations in the SRD5A2 cause a disorder of 46,XY sex development, termed 5alpha-reductase type 2 deficiency. (Review)

  6. Meta-analysis of 20 publications incorporating 30 case-control studies indicated that the SRD5A2 rs9282858 polymorphism may be a susceptible factor to prostate cancer.

  7. Although 4-dione is the main source of 5alpha-dihydrotestosterone in human preadipocytes, production of this steroid by 5 alpha-reductase isoenzymes (SRD5A1 (show SRD5A1 Antibodies), 2 and 3) mediates the inhibitory effect of both 4-dione and testosterone on preadipocyte differentiation.

  8. Mutations of the SRD5A2 gene is associated with 46, XY disorders of sex development.

  9. p.Ala65Pro mutation in the SRD5A2 gene causes 5alphaRD2 deficiency, especially in Turkey. V89L polymorphism may also be an important factor in the development of external genitalia

  10. deletion of exon 2 in the SRD5A2 gene causes various degrees of genital ambiguity leading to different sex of rearing in affected family members

Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2) Antigen Profile

Antigen Summary

This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH).

Alternative names and synonyms associated with Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2)

  • steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (SRD5A2) antibody
  • steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (srd5a2) antibody
  • steroid-5-alpha-reductase alpha polypeptide 2 (srd5a2) antibody
  • steroid 5 alpha-reductase 2 (Srd5a2) antibody
  • steroid 5-alpha-reductase 2 (ST5AR2) antibody
  • steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (Srd5a2) antibody
  • 5ART2 antibody
  • S5AR 2 antibody
  • Srd5a2 antibody
  • SRD5alpha2 antibody

Protein level used designations for SRD5A2

3-oxo-5-alpha-steroid 4-dehydrogenase 2 , steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) , steroid-5-alpha-reductase alpha polypeptide 2 , 5 alpha-SR2 , SR type 2 , steroid 5 alpha reductase type2 , steroid 5-alpha-reductase 2 , S5AR 2 , type II 5-alpha reductase , prostatic steroid 5-alpha-reductase type II

GENE ID SPECIES
527024 Bos taurus
772291 Gallus gallus
549867 Xenopus (Silurana) tropicalis
705676 Macaca mulatta
100125532 Oryzias latipes
94224 Mus musculus
397048 Sus scrofa
6716 Homo sapiens
64677 Rattus norvegicus
403715 Canis lupus familiaris
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