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Rat (Rattus) SRD5A2 ELISA Kit for Sandwich ELISA - ABIN1117890
Jang, Bae, Yuk, Han, Ha, Hwang, Yoon, Kim, Han: Seoritae extract reduces prostate weight and suppresses prostate cell proliferation in a rat model of benign prostate hyperplasia. in Evidence-based complementary and alternative medicine : eCAM 2014
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Prostate 5aR1 levels were positively correlated with adjusted prostate most severe lesion scores. Downregulation of androgen receptor (show AR ELISA Kits) and 5alpha-reductase 2, along with upregulation of 5a-reductase 1 in tumors may promote prostatic intraepithelial neoplasia and prostate cancer development in TRAMP (show DPT ELISA Kits) mice
observed an abnormally high expression levels of type 2 5alpha-reductase and 20alpha-HSD in the male and female adrenals, respectively, thus indirectly suggesting new roles for these sex-specific enzymes
The induction of Srd5a2 through SREBP-2 (show SREBF2 ELISA Kits) provides a mechanistic explanation for why even though statin therapy is effective in reducing cholesterol levels in treating hypercholesterolemia it does not compromise androgen production in clinical studies.
Findings suggest that 5alpha-reductases (5-AR) isoenzymes could be explored as a therapeutic target for urothelial bladder cancer (UBC (show RPS27A ELISA Kits)) with 5alpha-reductase inhibitors (5-ARI (show ARIH1 ELISA Kits)).
Lack of SRD5A2 expression in the prostate induces an androgenic to oestrogenic switch in human benign prostatic tissues.
deficiency of 5-alpha reductase type 2 was considered and SRD5A2 was sequenced. This identified homozygous pathogenic variants in SRD5A2 (p. Pro212Arg), which confirmed a diagnosis of deficiency of 5-alpha reductase type 2
Chromosomal anomalies and mutations of the SRD5A2 gene are associated with hypospadias.
Polymorphism in the SRD5A2 gene is associated with hypospadias.
In a recent study we reported associations between ALTs and single nucleotide polymorphisms (SNPs) in the genes encoding estrogen receptor 1 (ESR1 (show ESR1 ELISA Kits)), steroid-5-alpha-reductase, type 2 (SRD5A2) and sex hormone-binding globulin (SHBG (show SHBG ELISA Kits)). No associations between the previously associated SNPs in the genes ESR1 (show ESR1 ELISA Kits) and SRD5A2 and autistic-like traits could be seen in the large replication sample.
Studies indicate that enhanced 5alpha-reductase activity in subjects with polycystic ovary syndrome (PCOS) was associated with insulin (show INS ELISA Kits) resistance (IR) rather than obesity.
Mutations in the SRD5A2 cause a disorder of 46,XY sex development, termed 5alpha-reductase type 2 deficiency. (Review)
Meta-analysis of 20 publications incorporating 30 case-control studies indicated that the SRD5A2 rs9282858 polymorphism may be a susceptible factor to prostate cancer.
Although 4-dione is the main source of 5alpha-dihydrotestosterone in human preadipocytes, production of this steroid by 5 alpha-reductase isoenzymes (SRD5A1 (show SRD5A1 ELISA Kits), 2 and 3) mediates the inhibitory effect of both 4-dione and testosterone on preadipocyte differentiation.
This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH).
3-oxo-5-alpha-steroid 4-dehydrogenase 2
, steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
, steroid-5-alpha-reductase alpha polypeptide 2
, 5 alpha-SR2
, SR type 2
, steroid 5 alpha reductase type2
, steroid 5-alpha-reductase 2
, S5AR 2
, type II 5-alpha reductase
, prostatic steroid 5-alpha-reductase type II