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anti-Human BHMT2 Antibodies:
anti-Mouse (Murine) BHMT2 Antibodies:
anti-Rat (Rattus) BHMT2 Antibodies:
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A three-way interaction among maternal and fetal variants in BHMT2, GSTP1 (show GSTP1 Antibodies) and GPX3 (show GPX3 Antibodies) contribute to congenital heart defects
The faster evolutionary rate of BHMT2 overall suggests that selective constraints were reduced relative to BHMT (show BHMT Antibodies).
Multiple SNPs in BHMT (show BHMT Antibodies) and BHMT2 were identified to be associated with the occurrence of infant obstructive heart defects and interaction effects with maternal use of folic acid supplements.
No significant level of association was found with cleft lip with or without cleft palate and BHMT2 variants.
gene-gene interaction analysis revealed a significant epistatic interaction of BHMT2 (rs673752), PEMT (show PEMT Antibodies) (rs12325817), and PCYT1A (show PCYT1A Antibodies) (rs712012) with maternal NCL (show CLN5 Antibodies)/P susceptibility.
Hyperhomocysteinemia, a risk factor for coronary diseases, can be caused by genetic mutations in BHMT2 metabolism.
Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase.
Common genetic variation in BHMT (show BHMT Antibodies) and BHMT2 and functionally characterized BHMT (show BHMT Antibodies) SNPs.
the mouse liver extracts, containing the BHMT-2 homocysteine methyltransferase candidate for a similar activity, recognizes (S,S)-AdoMet (show MAT1A Antibodies) but not (R,S)-AdoMet (show MAT1A Antibodies).
Betaine-homocysteine methyltransferase 2 (Bhmt2) was identified as a diet-dependent genetic factor that affected susceptibility to acetaminophen-induced liver toxicity in mice.
Homocysteine is a sulfur-containing amino acid that plays a crucial role in methylation reactions. Transfer of the methyl group from betaine to homocysteine creates methionine, which donates the methyl group to methylate DNA, proteins, lipids, and other intracellular metabolites. The protein encoded by this gene is one of two methyl transferases that can catalyze the transfer of the methyl group from betaine to homocysteine. Anomalies in homocysteine metabolism have been implicated in disorders ranging from vascular disease to neural tube birth defects such as spina bifida. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
betaine-homocysteine methyltransferase 2
, Betaine--homocysteine S-methyltransferase 2
, betaine--homocysteine S-methyltransferase 2
, betaine--homocysteine S-methyltransferase 2-like
, S-methylmethionine--homocysteine S-methyltransferase BHMT2
, SMM-hcy methyltransferase