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Studies indicate that protein phosphatase methylesterase-1 (PME-1) negatively regulates protein phosphatase 2A (PP2A (show PPP2R4 ELISA Kits)) activity by highly complex mechanisms.
Data suggest that discovery of more potent protein phosphatase methylesterase-1 (PME-1) inhibitors may be beneficial for the treatment of endometrial cancer.
LCMT1 (show LCMT1 ELISA Kits)-PME-1 methylation equilibrium is critical for regulating mitotic spindle size and thereby proper cell division
this study suggests that the tightly linked regulatory loop comprised of the SIK2 (show SIK2 ELISA Kits)-PP2A (show PPP2R4 ELISA Kits) and CaMKI (show CAMK1 ELISA Kits) and PME-1 networks may function in fine-tuning cell proliferation and stress response.
PPME1 could be an attractive therapeutic target for a subset of gastric cancer and lung cancer.
Data indicate that PP2A (show PPP2R4 ELISA Kits) holoenzyme biogenesis and activity are controlled by five PP2A (show PPP2R4 ELISA Kits) modulators, consisting of alpha4, PTPA (show PPP2R4 ELISA Kits), LCMT1 (show LCMT1 ELISA Kits), PME-1 and TIPRL1, which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled.
GSK-3beta (show GSK3b ELISA Kits) can inhibit PP2A (show PPP2R4 ELISA Kits) by increasing the inhibitory L309-demethylation involving upregulation of PME-1 and inhibition of PPMT1 (show LCMT1 ELISA Kits)
Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.
We propose that stabilization of this inactive, nuclear PP2A (show PPP2R4 ELISA Kits) pool is a major in vivo function of PME-1.
Observations identify PME-1 expression as one mechanism by which ERK (show EPHB2 ELISA Kits) pathway activity is maintained in cancer cells and suggest an important functional role for PME-1 in the disease progression of human astrocytic gliomas.
protects protein phosphatase 2A from ubiquitin/proteasome degradation
PME-1 plays a critical role in differentiation of neuroblastoma (show ARHGEF16 ELISA Kits) cells.
targeted disruption of the PME-1 gene causes perinatal lethality in mice, a phenotype that correlates with a virtually complete loss of the demethylated form of PP2A in the nervous system and peripheral tissues
This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants.
protein phosphatase methylesterase 1
, phosphatase methylesterase 1
, protein phosphatase methylesterase-1
, likely mitochondrial ribosomal protein (YMS2)