Browse our Protein Phosphatase Methylesterase 1 Proteins (PPME1)

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Protein Phosphatase Methylesterase 1 Proteins (PPME1)
On www.antibodies-online.com are 15 Protein Phosphatase Methylesterase 1 (PPME1) Proteins from 5 different suppliers available. Additionally we are shipping Protein Phosphatase Methylesterase 1 Antibodies (67) and Protein Phosphatase Methylesterase 1 Kits (7) and many more products for this protein. A total of 94 Protein Phosphatase Methylesterase 1 products are currently listed.
Synonyms:
1110069N17Rik, 2700017M01Rik, DDBDRAFT_0204584, DDBDRAFT_0305014, DDB_0204584, DDB_0305014, F28M11.4, fk72d03, PME-1, PME1, PME1MGC133824, RGD1309683, wu:fk72d03, zgc:56239
list all proteins Gene Name GeneID UniProt
PPME1 51400 Q9Y570
PPME1 72590 Q8BVQ5
PPME1 361613 Q4FZT2

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Protein Phosphatase Methylesterase 1 Proteins (PPME1) by Origin

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Top referenced Protein Phosphatase Methylesterase 1 Proteins

  1. Human PPME1 Protein expressed in Escherichia coli (E. coli) - ABIN667510 : Gagnon, Hengartner, Desnoyers: The genes pme-1 and pme-2 encode two poly(ADP-ribose) polymerases in Caenorhabditis elegans. in The Biochemical journal 2002 (PubMed)
    Show all 2 references for 667510

More Proteins for Protein Phosphatase Methylesterase 1 Interaction Partners

Human Protein Phosphatase Methylesterase 1 (PPME1) interaction partners

  1. Studies indicate that protein phosphatase methylesterase-1 (PME-1) negatively regulates protein phosphatase 2A (PP2A (show PPP2R4 Proteins)) activity by highly complex mechanisms.

  2. Data suggest that discovery of more potent protein phosphatase methylesterase-1 (PME-1) inhibitors may be beneficial for the treatment of endometrial cancer.

  3. LCMT1 (show LCMT1 Proteins)-PME-1 methylation equilibrium is critical for regulating mitotic spindle size and thereby proper cell division

  4. this study suggests that the tightly linked regulatory loop comprised of the SIK2 (show SIK2 Proteins)-PP2A (show PPP2R4 Proteins) and CaMKI (show CAMK1 Proteins) and PME-1 networks may function in fine-tuning cell proliferation and stress response.

  5. PPME1 could be an attractive therapeutic target for a subset of gastric cancer and lung cancer.

  6. Data indicate that PP2A (show PPP2R4 Proteins) holoenzyme biogenesis and activity are controlled by five PP2A (show PPP2R4 Proteins) modulators, consisting of alpha4, PTPA (show PPP2R4 Proteins), LCMT1 (show LCMT1 Proteins), PME-1 and TIPRL1, which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled.

  7. GSK-3beta can inhibit PP2A (show PPP2R4 Proteins) by increasing the inhibitory L309-demethylation involving upregulation of PME-1 and inhibition of PPMT1 (show LCMT1 Proteins)

  8. Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.

  9. We propose that stabilization of this inactive, nuclear PP2A (show PPP2R4 Proteins) pool is a major in vivo function of PME-1.

  10. Observations identify PME-1 expression as one mechanism by which ERK (show EPHB2 Proteins) pathway activity is maintained in cancer cells and suggest an important functional role for PME-1 in the disease progression of human astrocytic gliomas.

Mouse (Murine) Protein Phosphatase Methylesterase 1 (PPME1) interaction partners

  1. protects protein phosphatase 2A from ubiquitin/proteasome degradation

  2. Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.

  3. PME-1 plays a critical role in differentiation of neuroblastoma (show ARHGEF16 Proteins) cells.

  4. targeted disruption of the PME-1 gene causes perinatal lethality in mice, a phenotype that correlates with a virtually complete loss of the demethylated form of PP2A (show PPP2R2B Proteins) in the nervous system and peripheral tissues

Protein Phosphatase Methylesterase 1 (PPME1) Protein Profile

Protein Summary

This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with Protein Phosphatase Methylesterase 1 (PPME1)

  • protein phosphatase methylesterase 1 (ppme1)
  • esterase/lipase/thioesterase family protein (AT4G10050)
  • protein phosphatase methylesterase 1 (LOC100358403)
  • protein phosphatase methylesterase 1 (PPME1)
  • protein phosphatase methylesterase 1 (Ppme1)
  • similar to S. cerevisiae PPE1 (YHR075C) mitochondrial ribosome small subunit protein YMS2, which resembles a phosphatase-methylesterase (PPE1)
  • 1110069N17Rik protein
  • 2700017M01Rik protein
  • DDBDRAFT_0204584 protein
  • DDBDRAFT_0305014 protein
  • DDB_0204584 protein
  • DDB_0305014 protein
  • F28M11.4 protein
  • fk72d03 protein
  • PME-1 protein
  • PME1 protein
  • PME1MGC133824 protein
  • RGD1309683 protein
  • wu:fk72d03 protein
  • zgc:56239 protein

Protein level used designations for PPME1

protein phosphatase methylesterase 1 , phosphatase methylesterase 1 , protein phosphatase methylesterase-1 , PME-1 , likely mitochondrial ribosomal protein (YMS2)

GENE ID SPECIES
335124 Danio rerio
826596 Arabidopsis thaliana
8623168 Dictyostelium discoideum AX4
100195184 Salmo salar
100358403 Oryctolagus cuniculus
446717 Xenopus laevis
419058 Gallus gallus
51400 Homo sapiens
612812 Canis lupus familiaris
535390 Bos taurus
72590 Mus musculus
361613 Rattus norvegicus
100173996 Pongo abelii
3635974 Candida albicans SC5314
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