We are preparing the requested document. Please wait, this may take a while...!
|Application / Reactivity||Rat (Rattus)||Mouse (Murine)|
|ELISA||14 Antibodies||15 Antibodies|
|Enzyme Immunoassay (EIA)||3 Antibodies||3 Antibodies|
|Immunocytochemistry (ICC)||2 Antibodies||2 Antibodies|
|Immunofluorescence (IF)||5 Antibodies||5 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||1 Antibodies||1 Antibodies|
|Immunohistochemistry (IHC)||4 Antibodies||5 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||3 Antibodies||4 Antibodies|
|Immunoprecipitation (IP)||1 Antibodies||1 Antibodies|
|Western Blotting (WB)||19 Antibodies||25 Antibodies|
|Flow Cytometry (FACS)||2 Antibodies|
|Antigen||CAP-GLY Domain Containing Linker Protein 1 (CLIP1) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This CLIP1 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
|4 references available|
|Supplier||Log in to see|
Product Details anti-CLIP1 AntibodyTarget Details CLIP1 Application Details Handling References for anti-CLIP1 Antibody (ABIN499641) Images
|Specificity||This antibody reacts to CLIP170.|
|Purification||Affinity chromatography purified via peptide column|
|Immunogen||CLIP170 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human CLIP170.|
Target Details CLIP1Product Details anti-CLIP1 Antibody Application Details Handling References for anti-CLIP1 Antibody (ABIN499641) Images back to top
|Alternative Name||CLIP1 / Restin (CLIP1 Antibody Abstract)|
|Background||CLIP170 was initially identified as a new type of intermediate filament associated protein that is highly expressed in Reed-Sternberg cells, the tumoral cells diagnostic for Hodgkin's disease. Later experiments showed that it is located at microtubule plus ends and is required for the binding of endocytic carrier vesicles. CLIP170 has also been suggested to act with LIS1, a protein implicated in brain development, to regulate dynein/dynactin binding microtubules. Other studies suggest that CLIP170 can influence the formation of lamellipodia and cell invasion by invasive breast cancer cells by regulating the release of kinesin and IQGAP1 from a complex of those proteins, CLIP170 and Rac1. At least two isoforms of CLIP170 are known to exist.Synonyms: CAP-Gly domain-containing linker protein 1, CLIP-170, CYLN1, Cytoplasmic linker protein 1, Cytoplasmic linker protein 170 alpha-2, RSN, Reed-Sternberg intermediate filament-associated protein|
Application DetailsProduct Details anti-CLIP1 Antibody Target Details CLIP1 Handling References for anti-CLIP1 Antibody (ABIN499641) Images back to top
ELISA. Western Blot: CLIP170 antibody can be used for detection of CLIP170 at 0.5 - 1 μg/mL. Immunofluorescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-CLIP1 Antibody Target Details CLIP1 Application Details References for anti-CLIP1 Antibody (ABIN499641) Images back to top
|Buffer||PBS containing 0.02 % sodium azide.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store the antibody undiluted at 2-8 °C.|
References for anti-CLIP1 Antibody (ABIN499641)Product Details anti-CLIP1 Antibody Target Details CLIP1 Application Details Handling Images back to top
Suzuki, Takahashi: "Regulation of lamellipodia formation and cell invasion by CLIP-170 in invasive human breast cancer cells." in: Biochemical and biophysical research communications, Vol. 368, Issue 2, pp. 199-204, 2008 (PubMed).
Diamantopoulos, Perez, Goodson et al.: "Dynamic localization of CLIP-170 to microtubule plus ends is coupled to microtubule assembly." in: The Journal of cell biology, Vol. 144, Issue 1, pp. 99-112, 1999 (PubMed).
Bilbe, Delabie, Brüggen et al.: "Restin: a novel intermediate filament-associated protein highly expressed in the Reed-Sternberg cells of Hodgkin's disease." in: The EMBO journal, Vol. 11, Issue 6, pp. 2103-13, 1992 (PubMed).
Pierre, Scheel, Rickard et al.: "CLIP-170 links endocytic vesicles to microtubules." in: Cell, Vol. 70, Issue 6, pp. 887-900, 1992 (PubMed).
ImagesProduct Details anti-CLIP1 Antibody Target Details CLIP1 Application Details Handling References for anti-CLIP1 Antibody (ABIN499641) back to top