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Browse our KIF2C Proteins (KIF2C)

Full name:
Kinesin Family Member 2C Proteins (KIF2C)
On www.antibodies-online.com are 6 Kinesin Family Member 2C (KIF2C) Proteins from 4 different suppliers available. Additionally we are shipping KIF2C Antibodies (85) and many more products for this protein. A total of 101 KIF2C products are currently listed.
Synonyms:
4930402F02Rik, ESTM5, kcm1, KIF2C, Knsl6, KRP2, mcak, MGC89391, si:ch211-61f14.1, X83316
list all proteins Gene Name GeneID UniProt
KIF2C 11004 Q99661
KIF2C 73804 Q922S8
KIF2C 171529 Q62909

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KIF2C Proteins (KIF2C) by Origin

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More Proteins for KIF2C Interaction Partners

Human Kinesin Family Member 2C (KIF2C) interaction partners

  1. MCAK is involved in directional migration and invasion of tumor cells.

  2. the Aurora B (show AURKB Proteins)-PLK1 signaling at the kinetochore orchestrates MCAK activity, which is essential for timely correction of aberrant kinetochore attachment to ensure accurate chromosome segregation during mitosis.

  3. MCAK activity is modulated by Plk1 phosphorylation on S632/S633 in mitosis.

  4. These results demonstrate that the structural change of Kif2C-ATP upon binding to microtubule ends is sufficient for tubulin (show TUBB Proteins) release, whereas ATP hydrolysis is not required

  5. Ras regulates KIF2C to control cell migration pathways in transformed human bronchial epithelial cells.

  6. A dynamic interaction of MCAK-TIP150 (show KIAA0774 Proteins) orchestrated by Aurora A (show AURKA Proteins)-mediated phosphorylation governs entosis via regulating microtubule plus-end dynamics and cell rigidity.

  7. this study suggests a new mechanism by which Plk1 regulates MCAK: by regulating its degradation and hence controlling its turnover in mitosis.

  8. up-regulation of KIF2C and KIF2A by ERK1/2 caused aberrant lysosomal positioning and mTORC1 activity in a mutant K-Ras-dependent cancer and cancer model.

  9. A Rac1-Aurora A (show AURKA Proteins)-MCAK signaling pathway mediates endothelial cell polarization and directional migration by promoting regional differences in microtubule dynamics.

  10. result suggested E403K mutation in mitotic centromere-associated kinesin protein (show KIF2B Proteins) as highly damaging and showed strong concordance to the previously observed colorectal cancer mutations aggregation tendency and energy value changes

Mouse (Murine) Kinesin Family Member 2C (KIF2C) interaction partners

  1. PAK1 (show PAK1 Proteins) phosphorylates MCAK and regulates both its localization and function.

  2. MCAK appears to possess a unique distribution and function in oocyte maturation.

  3. MCAK contributes to chromosome alignment in meiosis I, but is not necessary for preventing chromosome segregation errors.

  4. Possible functions of MCAK at the inner centromere domain and at the perikinetochoric ring during both meiotic divisions.

  5. Shugoshin 2 is necessary for the loading of MCAK at the inner centromere, but is dispensable for the loading of the outer kinetochore proteins BubR1 (show BUB1B Proteins) and CENP-E (show CENPE Proteins).

Xenopus laevis Kinesin Family Member 2C (KIF2C) interaction partners

  1. MCAK colocalized with NuMA and XMAP215 at the center of Ran asters where its activity is regulated by Aurora A (show AURKA Proteins)-dependent phosphorylation of S196, which contributes to proper pole focusing

  2. This study reveals a new role for Aurora B (show AURKB Proteins), which is to prevent excess MCAK binding to chromatin to facilitate chromatin-nucleated spindle assembly.

  3. MCAK regulation of cytoplasmic and spindle-associated (show HAUS1 Proteins) microtubules can be differentiated by Aurora B (show AURKB Proteins)-dependent phosphorylation

  4. These data support a model in which Nup98 (show NUP98 Proteins) interacts with microtubules and antagonizes MCAK activity, thus promoting bipolar spindle assembly.

KIF2C Protein Profile

Protein Summary

The protein encoded by this gene is a member of kinesin-like protein family. Proteins of this family are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein is important for anaphase chromosome segregation and may be required to coordinate the onset of sister centromere separation.

Alternative names and synonyms associated with KIF2C

  • kinesin family member 2C (KIF2C)
  • kinesin family member 2C (kif2c)
  • kinesin family member 2C (Kif2c)
  • 4930402F02Rik protein
  • ESTM5 protein
  • kcm1 protein
  • KIF2C protein
  • Knsl6 protein
  • KRP2 protein
  • mcak protein
  • MGC89391 protein
  • si:ch211-61f14.1 protein
  • X83316 protein

Protein level used designations for KIF2C

kinesin family member 2C , kinesin-like protein KIF2C , kinesin-like protein KIF2C-like , kinesin-like 6 , kinesin-like protein 6 , mitotic centromere-associated kinesin , MCAK , kinesin-related protein 2 , Kinesin-like protein 6 , kinesin central motor 1 , xKCM1

GENE ID SPECIES
424583 Gallus gallus
448620 Xenopus (Silurana) tropicalis
456548 Pan troglodytes
475382 Canis lupus familiaris
705381 Macaca mulatta
100014033 Monodelphis domestica
100052754 Equus caballus
100136875 Danio rerio
100391603 Callithrix jacchus
100461300 Pongo abelii
100474833 Ailuropoda melanoleuca
100516205 Sus scrofa
100558145 Anolis carolinensis
100590717 Nomascus leucogenys
11004 Homo sapiens
73804 Mus musculus
171529 Rattus norvegicus
533161 Bos taurus
100689309 Cricetulus griseus
380006 Xenopus laevis
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