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These results suggest that a change in the intracellular calcium level plays a role in regulation of the secretory pathway via interaction of ALG-2 (show PDCD6 Proteins) with MISSL and MAP1B.
The found of this study suggested that possible roles of MAP1B genes in working memory performance in ADHD patients
KIRREL3 interacting proteins MAP1B and MYO16 are potential candidates for intellectual disability and autism spectrum disorder.
signal transduction pathways downstream of 5-HT6R (show HTR6 Proteins) are regulated by MAP1B, which might play a role in 5-HT6R (show HTR6 Proteins)-mediated signaling in the brain.
The the MAP1B-LC1-mediated regulation most likely involves an internalization of the channels via a dynamin (show DNM1 Proteins) and clathrin-dependent pathway.
An interaction between MAP1B LC1 and the ubiquitin-conjugating enzyme (show Ube2t Proteins) UBE2L3 (show UBE2L3 Proteins).
Localization of MAP1B is altered in amyotrophic lateral sclerosis spinal cords in a transgenic animal model.
Yeast-two-hybrid screening using human LRRK2 (show LRRK2 Proteins) kinase domain as bait identified microtubule associated protein 1B (MAP1B) as a LRRK2 (show LRRK2 Proteins) interactor.
We suggest a role for Stau2 (show STAU2 Proteins) in the generation and regulation of Map1b mRNA containing granules that are required for mGluR (show GRM8 Proteins)-long-term depression
These observations define a new and crucial function of MAP1B that is required for efficient cross-talk between microtubules and the actin cytoskeleton during neuronal polarization.
MAP1B confers increased stability to tyrosinated and acetylated, but not detyrosinated microtubules.
Both FMRP (show FMR1 Proteins) deficiency in Fmr1 (show FMR1 Proteins)(I304N) mice and Fmr1 (show FMR1 Proteins) knockdown impeded the axonal delivery of miR (show MLXIP Proteins)-181d, Map1b, and Calm1 and reduced the protein levels of MAP1B and calmodulin in axons.
MAP1B is a specific marker protein of the podocyte microtubular cytoskeleton.
Although MAP1A (show MAP1A Proteins) and MAP1B protein levels are not affected in the tulp1 (show TULP1 Proteins)-/- retina, they are no longer localized to the outer segment of photoreceptors.
The morphology, phenotype, regional distribution, proliferative dynamics, and stage-specific marker expression of Map5 cells in the rabbit and mouse central nervous system, were characterized.
The MAP1B-Tiam1 (show TIAM1 Proteins)-Rac1 relay is essential for spine structural plasticity and removal of AMPA (show GRIA3 Proteins) receptors from synapses during long-term depression.
MAP1B interacts directly with EB1 (show MAPRE1 Proteins) and EB3 (show MAPRE3 Proteins) (EBs), two core 'microtubule plus-end tracking proteins' ( TIPs), and sequesters them in the cytosol of developing neuronal cells.
MKK7 (show MAP2K7 Proteins) is specifically phosphorylated in the neurite shaft which triggers Map1b phosphorylation to regulate microtubule bundling leading to neurite elongation.
The interaction between the conserved COOH-terminal 125-amino acid domain (which is located in the light chains of MAP1A (show MAP1A Proteins), MAP1B, and MAP1S (show MAP1S Proteins)) and alpha1-syntrophin (show SNTA1 Proteins) is direct and occurs through the pleckstrin (show PLEK Proteins) homology domain 2 (PH2 (show PhC2 Proteins)).
Mutation of the Map1b binding site of Na(v)1.6 prevented generation of sodium current in transfected cells. The data indicate that Map1b facilitates trafficking of Na(v)1.6 to the neuronal cell surface
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system.
, microtubule associated protein 1B
, Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X))
, microtubule-associated protein 5