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|Antigen||rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This ROCK2 antibody is un-conjugated Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|2 references available|
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Product Details anti-ROCK2 AntibodyTarget Details ROCK2 Application Details Handling References for anti-ROCK2 antibody (ABIN673359) Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from human ROCK2|
Target Details ROCK2Product Details anti-ROCK2 Antibody Application Details Handling References for anti-ROCK2 antibody (ABIN673359) Images back to top
|Alternative Name||Rock2 (ROCK2 Antibody Abstract)|
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP3, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p9RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation.
Subcellular location: Cytoplasm
Synonyms: ROCK-II, Rho-associated protein kinase 2, Rho kinase 2, Rho-associated, coiled-coil-containing protein kinase 2, Rho-associated, coiled-coil-containing protein kinase II, p164 ROCK-2, ROCK2, KIAA619
|Research Area||Cancer, Apoptosis/Necrosis|
|Pathways||Microtubule Dynamics, WNT Signaling, Tube Formation|
Application DetailsProduct Details anti-ROCK2 Antibody Target Details ROCK2 Handling References for anti-ROCK2 antibody (ABIN673359) Images back to top
|Restrictions||For Research Use only|
HandlingProduct Details anti-ROCK2 Antibody Target Details ROCK2 Application Details References for anti-ROCK2 antibody (ABIN673359) Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at -20°C|
|Expiry Date||12 months|
References for anti-ROCK2 antibody (ABIN673359)Product Details anti-ROCK2 Antibody Target Details ROCK2 Application Details Handling Images back to top
|Product cited in:||
He, Wei, Du, Meng, Zheng, Lai, Yao, Zhou, Wang, Luo, Ma, Zhang: "Transcription of HOTAIR is regulated by RhoC-MRTF-A-SRF signaling pathway in human breast cancer cells." in: Cellular signalling, Vol. 31, pp. 87-95, 2017 Method employed by authors: Western Blotting (WB) (Sample species: Human).
Wang, Zhang, Wang, Zhang, Mao, Zhuang, Tang, Luo, Zhou, Zhang: "Vascular endothelial growth factor stimulates endothelial differentiation from mesenchymal stem cells via Rho/myocardin-related transcription factor--a signaling pathway." in: The international journal of biochemistry & cell biology, Vol. 45, Issue 7, pp. 1447-56, 2013 Method employed by authors: Western Blotting (WB) (Sample species: Rat (Rattus)).
ImagesProduct Details anti-ROCK2 Antibody Target Details ROCK2 Application Details Handling References for anti-ROCK2 antibody (ABIN673359) back to top