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Browse our Spastin Proteins (SPAST)

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Spastin Proteins (SPAST)
On are 7 Spastin (SPAST) Proteins from 3 different suppliers available. Additionally we are shipping Spastin Antibodies (21) and Spastin Kits (8) and many more products for this protein. A total of 36 Spastin products are currently listed.
ADPSP, CG5977, D-spastin, Dmel\\CG5977, Dspastin, FSP2, LOC100224472, mKIAA1083, Spas, SPAST, Spg4, zgc:85952
list all proteins Gene Name GeneID UniProt
SPAST 50850 Q9QYY8

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Spastin Proteins (SPAST) by Origin

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More Proteins for Spastin Interaction Partners

Fruit Fly (Drosophila melanogaster) Spastin (SPAST) interaction partners

  1. targeting sequence directs spastin to the surface of lipid droplets. Depletion of the homologous spastin proteins in both flies and worms affects lipid droplet number and triacylglycerol content.

  2. The spastin is a key regulator of axon regeneration, and initiation of regeneration is extremely sensitive to the spastin copy number.

  3. Dendritic growth is regulated by Kruppel-like factor dendritic arbor reduction protein 1 (Dar1) suppressing the expression of microtubule-severing protein (show KATNA1 Proteins) spastin.

  4. spastin is essential for apical domain biogenesis during rhabdomere elongation in Drosophila photoreceptor morphogenesis

  5. Exogenous expression of wild-type Drosophila or human spastin rescues behavioral and cellular defects in spastin null flies equivalently.

  6. Here we identify the predicted gene product CG5977 as the Drosophila homolog of the human spastin gene, with much higher sequence similarities than any other related AAA (show AAAS Proteins) domain protein in the fly.

  7. D-spastin displays ATPase activity and uses energy from ATP hydrolysis to sever and disassemble microtubules; disease mutations abolish or partially interfere with these activities.

  8. Spastin and Fidgetin are utilized to stimulate microtubule minus-end depolymerization and flux; they concentrate at centrosomes, where they catalyze the turnover of gamma-tubulin (show TUBG1 Proteins).

  9. X ray structure; data support a model in which spastin pulls the C terminus of tubulin (show TUBB Proteins) through its central pore, generating a mechanical force that destabilizes tubulin-tubulin (show TUBB Proteins) interactions within the microtubule lattice

Zebrafish Spastin (SPAST) interaction partners

  1. The results suggest that the spinal cord motor neuron axon outgrowth of zebrafish is regulated by the interaction between spastin and protrudin (show ZFYVE27 Proteins).

  2. Simultaneous knockdown of spastin and katanin caused a more severe phenotype than did individual knockdown of either gene, suggesting that they have different but related functions in supporting axon outgrowth.

  3. Reduced spg4 function caused dramatic defects in motor axon outgrowth without affecting the events driving the initial specification of motor neurones.

Human Spastin (SPAST) interaction partners

  1. We identified two novel mutations and two previously reported mutations in SPAST and ATL1 (show ATL1 Proteins), respectively. The family with the ATL1 (show ATL1 Proteins) c.1204T>G mutation exhibited male-lethality, female infancy-onset, and pseudo- X-linked dominant transmission

  2. Using human-engineered and differentially modified microtubules study finds that glutamylation is the main regulator of the hereditary spastic paraplegia microtubule severing enzyme spastin.

  3. Patients with deletions of exons in the SPAST gene showed pure hereditary spastic paraplegia.

  4. Novel SPAST pathogenic variants were identified in Korean patients with hereditary spastic paraplegia.

  5. The coexistence of mutations in SPAST and FSHD was confirmed in our proband and in two siblings

  6. The spastin as a microtubule-severing protein (show KATNA1 Proteins) was an important mechanistic breakthrough, it seems certain that insufficient microtubule severing alone is not an adequate explanation for HSP-SPG4.

  7. SPAST mutations are common in Chinese patients with pure hereditary spastic paraplegia

  8. Data showed 3 micro-mutations and 2 exon deletions in SPAST gene and 2 micro-mutations in ATL1 (show ATL1 Proteins) gene in this cohort of Chinese patients with spastic paraplegia.

  9. NA14 may act as an adaptor protein regulating SPG4 localization to centrosomes, temporally and spatially regulating the microtubule-severing activity of SPG4 that is particularly critical during the cell cycle and neuronal development.

  10. ESCRT-III, VPS4 (show VPS4A Proteins) and spastin cooperate to coordinate nuclear envelope sealing and spindle disassembly at nuclear envelope-microtubule intersection sites during mitotic exit to ensure nuclear integrity and genome safeguarding

Mouse (Murine) Spastin (SPAST) interaction partners

  1. Spastin is recruited by microtubules polyglutamylation, induced by Tau missorting triggered translocalization of TTLL6 (show TTLL6 Proteins) (Tubulin-Tyrosine-Ligase (show TTL Proteins)-Like-6) into dendrites

  2. early and marked impairment of microtubule dynamics all along the axons of spastin-deficient cortical neurons, which is likely to be responsible for the occurrence of axonal swellings and cargo stalling

  3. we aimed to identify the critical promoter regions of SPG4 gene and effects of Elk1 (show ELK1 Proteins) on SPG4 gene expression

  4. Sequence analysis of the SPG4 (spastin) gene identified a novel 1593 C > T (GLN490Stop) mutation in hereditary spastic paraplegia with cerebellar ataxia (show USP14 Proteins).

  5. two modes by which microtubule severing occurs during axonal branch formation, based on the concentration of spastin at branch sites and on local detachment from microtubules of molecules such as tau that regulate the severing properties of P60-katanin (show KATNA1 Proteins)

  6. These results strongly support a direct role for defective axonal transport in the pathogenesis of HSP because of spastin mutation.

Cow (Bovine) Spastin (SPAST) interaction partners

  1. A defective SPAST gene in cattle is associated with a recessive, congenital neurodegenerative disease, which is characterized by pathological changes of the myelin sheaths in the spinal cord.

Spastin (SPAST) Protein Profile

Protein Summary

This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The encoded ATPase may be involved in the assembly or function of nuclear protein complexes. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequences have not been determined. Mutations associated with this gene cause the most frequent form of autosomal dominant spastic paraplegia 4.

Alternative names and synonyms associated with Spastin (SPAST)

  • spastin (spas)
  • spastin (spast)
  • spastin (SPAST)
  • spastin (LOC100224472)
  • spastin (LOC100345919)
  • spastin (Spast)
  • ADPSP protein
  • CG5977 protein
  • D-spastin protein
  • Dmel\\CG5977 protein
  • Dspastin protein
  • FSP2 protein
  • LOC100224472 protein
  • mKIAA1083 protein
  • Spas protein
  • SPAST protein
  • Spg4 protein
  • zgc:85952 protein

Protein level used designations for Spastin Proteins (SPAST)

CG5977-PA , CG5977-PB , CG5977-PC , D-spastin , Dm-Spastin , dspastin , spas-PA , spas-PB , spas-PC , spasin , spg4 , spastin , spastic paraplegia 4 (autosomal dominant; spastin) , spastin-like , spastic paraplegia 4 protein , spastic paraplegia 4 homolog , spastic paraplegia 4 (autosomal dominant , neuronal spastin

42846 Drosophila melanogaster
405851 Danio rerio
459133 Pan troglodytes
549207 Xenopus (Silurana) tropicalis
608582 Canis lupus familiaris
706264 Macaca mulatta
100224472 Taeniopygia guttata
100345919 Oryctolagus cuniculus
100408469 Callithrix jacchus
100599689 Nomascus leucogenys
6683 Homo sapiens
50850 Mus musculus
362700 Rattus norvegicus
521442 Bos taurus
421481 Gallus gallus
396584 Sus scrofa
446560 Xenopus laevis
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