Browse our TUBB2B Proteins (TUBB2B)

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Tubulin, beta 2B Proteins (TUBB2B)
On are 6 Tubulin, beta 2B (TUBB2B) Proteins from 4 different suppliers available. Additionally we are shipping TUBB2B Antibodies (61) and many more products for this protein. A total of 71 TUBB2B products are currently listed.
2410129E14Rik, bA506K6.1, fb40f09, N-Tub, n-tubulin, NBT, NST, ntubulin, PMGYSA, RGD1309427, TUBB, Tubb2, TUBB2A, TUBB2B, tubb2c, wu:fb40f09, Xn-tubulin
list all proteins Gene Name GeneID UniProt
TUBB2B 347733 Q9BVA1
TUBB2B 73710 Q9CWF2
TUBB2B 291081 Q3KRE8

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TUBB2B Proteins (TUBB2B) by Origin

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Human Tubulin, beta 2B (TUBB2B) interaction partners

  1. The TUBB2B mutation described here represents an unusual recessive mode of inheritance for missense-mediated tubulinopathies and reinforces the sensitivity of the developing cerebellum to microtubule defects.

  2. At the cellular level, the p.Cys239Phe TUBB2B mutant leads to tubulin (show TUBB Proteins) heterodimerization impairment, decreased ability to incorporate into the cytoskeleton, microtubule dynamics alteration, with an accelerated rate of depolymerization

  3. off-target, non-immune mediated effects of the mTOR (show FRAP1 Proteins)-inhibitor everolimus on the podocyte cytoskeleton might involve regulation of microtubules, revealing a potential novel role of TUBB2B and DCDC2 (show DCDC2 Proteins) in glomerular podocyte development

  4. The association of polymicrogyria with thin or absent corpus callosum, dysmorphic basal ganglia, brainstem and vermis hypoplasia is highly likely to result from mutations in TUBB2B.

  5. The present study confirms that mutations in tubulin (show TUBB Proteins) genes are responsible for complex brain malformation.

  6. Congenital fibrosis of the extraocular muscles and intellectual disability segregate with a heterozygous mutation in TUBB2B.

  7. The TUBB2B and TUBA1 (show TUBA4A Proteins) coding regions have been sequenced in patients with cortical malformations associated with these genes.

  8. Three new TUBB2B mutations have been identified in three unrelated patients with a diffuse and rather symmetrical cortical abnormality.

  9. Brain malformations are associated with mutations in the beta-tubulin (show TUBB Proteins) gene TUBB2B, supporting its critical role in migration/organization and axon guidance processes.

  10. TUBB2B is required for neuronal migration two disease-associated mutations lead to impaired formation of tubulin (show TUBB Proteins) heterodimers.

Mouse (Murine) Tubulin, beta 2B (TUBB2B) interaction partners

  1. The data presented here demonstrate that a heterozygous Tubb2b brdp/+ mutation in mice leads to significant spatial learning and memory reductions and conditioned contextual, but not cued, fear deficits.

  2. study shows TUBB2B significantly upregulated in melanoma multinucleated giant cells, which indicates that it may play an important role in melanoma metastasis.

  3. Study showed that Tubb2b is expressed in Sox2 (show SOX2 Proteins)- and Tbr2 (show EOMES Proteins)-positive neuronal progenitors and, at higher levels, in Dcx (show DCX Proteins)-positive postmitotic neurons in the developing mouse neocortex

  4. Results show that the missense mutation at a highly conserved residue (N247S) in Tubb2b gene represents the most severely affected mouse tubulin (show TUBB Proteins) phenotype involving neuronal proliferation and survival.

Cow (Bovine) Tubulin, beta 2B (TUBB2B) interaction partners

  1. A combination of molecular dynamics simulations and computational docking is used to identify a single high-affinity binding site on five beta-tubulin (show TUBB Proteins) microtubule inhibitors adjacent to the exchangeable GTP (show AK3 Proteins) site on beta-tubulin (show TUBB Proteins).

  2. Results suggest that the axonemal motif sequences of betaI, betaIV and betaV tubulin (show TUBB Proteins) are essential for ciliary function.

  3. These data indicate that phosphorylation of tubulin (show TUBB Proteins) by Cdk1 (show CDK1 Proteins) could be involved in the regulation of microtubule dynamics during mitosis.

TUBB2B Protein Profile

Protein Summary

The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. This gene is highly similar to TUBB2A and TUBB2C. Defects in this gene are a cause of asymmetric polymicrogyria.

Alternative names and synonyms associated with TUBB2B

  • tubulin, beta 2b (tubb2b)
  • tubulin, beta 2B class IIb (tubb2b)
  • tubulin, beta 2B class IIb (TUBB2B)
  • tubulin, beta 2B (TUBB2B)
  • hypothetical protein (MW1385)
  • tubulin, beta 2B class IIB (Tubb2b)
  • tubulin, beta 2B class IIb (Tubb2b)
  • 2410129E14Rik protein
  • bA506K6.1 protein
  • fb40f09 protein
  • N-Tub protein
  • n-tubulin protein
  • NBT protein
  • NST protein
  • ntubulin protein
  • PMGYSA protein
  • RGD1309427 protein
  • TUBB protein
  • Tubb2 protein
  • TUBB2A protein
  • TUBB2B protein
  • tubb2c protein
  • wu:fb40f09 protein
  • Xn-tubulin protein

Protein level used designations for Tubulin, beta 2B Proteins (TUBB2B)

tubulin, beta 2b , neural beta-tubulin , tubb-paralog , tubulin, beta 2 , beta-tubulin class-II , tubulin beta-2 chain , tubulin, beta 2B , hypothetical protein , class II beta-tubulin isotype , class IIb beta-tubulin , tubulin beta-2B chain , tubulin, beta polypeptide paralog , tubulin, beta 2A class IIa , tubulin, beta polypeptide , beta-tubulin T beta15 (aa 1-445) , t beta-15

322003 Danio rerio
394889 Xenopus (Silurana) tropicalis
420883 Gallus gallus
462400 Pan troglodytes
478702 Canis lupus familiaris
1003497 Staphylococcus aureus subsp. aureus MW2
100021036 Monodelphis domestica
347733 Homo sapiens
73710 Mus musculus
281555 Bos taurus
291081 Rattus norvegicus
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