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Continuous ESCRT-III remodelling by dynamic subunit turnover is regulated by Vps4 to mediate membrane remodelling during cytokinesis.
associations were noted between the striatal node, hyperactivity, and the vacuolar protein sorting-associated protein 4A (VPS4A) gene in humans, and the causal role of Vps4 for hyperactivity was validated in Drosophila
These results point to the existence of previously undetected biological functions of the FTase alpha (show FNTA Proteins) subunit (show POLG Proteins) that includes control of intracellular membrane trafficking.
these experiments suggest that miR-16 (show GDE1 Proteins) and VPS4a expression are altered in end-stage heart failure and in response to unloading with a left ventricular assist device
Ca2 (show CA2 Proteins)+-dependent accumulation of ESCRT III-Vps4 complex following large focal injury to the cell membrane and identify the role of ALG-2 (show PDCD6 Proteins) as the initiator of sequential ESCRT III-Vps4A/B complex assembly.
Vps4A may function as a tumor suppressor, which utilizes exosomes as mediators to regulate the secretion and uptake of miRNAs in hepatoma cells; these observations provide new insights into the development of HCC (show FAM126A Proteins).
Vps4 stimulatory element of the cofactor Vta1 (show VTA1 Proteins) contacts the ATPase Vps4 alpha7 and alpha9 subunits to stimulate ATP hydrolysis.
Propose that the abscission checkpoint is mediated by ANCHR and CHMP4C (show CHMP4C Proteins) through retention of VPS4 at the midbody ring.
VPS4 is required for endosomal transport of LDL cholesterol in HeLa cells.
silencing CHMP6 (show CHMP6 Proteins) and VPS4A also blocked epidermal growth factor receptor (EGFR (show EGFR Proteins)) recycling
A common substrate recognition mode conserved between katanin p60 (show STIP1 Proteins) and VPS4 governs microtubule severing and membrane skeleton reorganization
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16\; the gene for the other resides on chromosome 18.
vacuolar protein sorting-associated protein 4A
, vacuolar sorting protein 4
, vacuolar protein sorting 4 homolog A (S. cerevisiae)
, vacuolar protein sorting factor 4A
, vacuolar protein sorting 4a
, vacuolar protein sorting protein 4a
, vacuolar protein sorting 4 homolog A