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p53 (show TP53 Proteins)-dependent control of CDC7 levels is essential for blocking G1/S cell-cycle transition upon genotoxic stress.
we propose that phosphorylation of TOP2A (show TOP2A Proteins) by CDC7/DBF4 (show DBF4 Proteins) in early S-phase prevents its localization and/or activity at centromeres, and inhibition of TOP2A (show TOP2A Proteins) function could be relevant to prevent premature separation of centromeric DNA.
The data support a model where Cdc7 (de)phosphorylation is the molecular switch for the activation and inactivation of DNA replication in mitosis, directly connecting Cdc7 and PP1a (show PPP1CA Proteins)/Cdk1 (show CDK1 Proteins) to the regulation of once-per-cell cycle DNA replication in mammalian cells.
Our data show that Cdc7 is highly expressed in colorectal cancer
The presence of the index SNP rs1192415 (TGFBR3 (show TGFBR3 Proteins)-CDC7) was associated with visual field progression in POAG (primary open-angle glaucoma) patients.
MiR (show MLXIP Proteins)-630 promoted apoptosis by downregulation of CDC7.
The state of DUE-B phosphorylation is maintained by the equilibrium between Cdc7-dependent phosphorylation and PP2A (show PPP2R4 Proteins)-dependent dephosphorylation.
The interaction between Claspin and Cdc7 is not dependent on Cdc7 kinase activity, but Claspin interaction with the DNA helicase subunit Mcm2 (show MCM2 Proteins) is lost upon Cdc7 inhibition.
huCdc7 may play an important role in the development and progression of colorectal cancer.
The results suggest that CDC7 expression level can be specific prognostic factors for Diffuse large B-cell lymphoma patients
Cdc7 physically and functionally interacts with Nkx2.5 to regulate Myocd promoter activity
Cdc7 mediates SMC (show DYM Proteins) differentiation through a mechanism distinct from cell proliferation.
MCM4 (show MCM4 Proteins) phosphorylation by Cdc7 kinase facilitates its interaction with Cdc45 (show CDC45 Proteins) on chromatin
This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected.
cell division cycle 7-related protein kinase
, CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1
, CDC7-related kinase
, cell division cycle 7 homolog
, cell division cycle 7-like protein 1
, cell division cycle 7-like 1