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Our data show that Cdc7 is highly expressed in colorectal cancer
The presence of the index SNP rs1192415 (TGFBR3 (show TGFBR3 Proteins)-CDC7) was associated with visual field progression in POAG (primary open-angle glaucoma) patients.
MiR (show MLXIP Proteins)-630 promoted apoptosis by downregulation of CDC7.
The state of DUE-B phosphorylation is maintained by the equilibrium between Cdc7-dependent phosphorylation and PP2A (show PPP2R4 Proteins)-dependent dephosphorylation.
The interaction between Claspin and Cdc7 is not dependent on Cdc7 kinase activity, but Claspin interaction with the DNA helicase subunit Mcm2 (show MCM2 Proteins) is lost upon Cdc7 inhibition.
huCdc7 may play an important role in the development and progression of colorectal cancer.
The results suggest that CDC7 expression level can be specific prognostic factors for Diffuse large B-cell lymphoma patients
Cdc7 phosphorylates and interacts with Tob (show TDO2 Proteins) to inhibit the Cul4-DDB1 (show DDB1 Proteins)(Cdt2 (show DTL Proteins))-dependent Tob (show TDO2 Proteins) degradation.
cell death process induced by Cdc7 depletion
bipartite interaction between Cdc7 and Dbf4 (show DBF4 Proteins)/ASK subunits facilitates ATP binding and substrate recognition by the Cdc7 kinase.
Cdc7 physically and functionally interacts with Nkx2.5 to regulate Myocd promoter activity
Cdc7 mediates SMC (show DYM Proteins) differentiation through a mechanism distinct from cell proliferation.
MCM4 (show MCM4 Proteins) phosphorylation by Cdc7 kinase facilitates its interaction with Cdc45 (show CDC45 Proteins) on chromatin
This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected.
cell division cycle 7-related protein kinase
, CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1
, CDC7-related kinase
, cell division cycle 7 homolog
, cell division cycle 7-like protein 1
, cell division cycle 7-like 1