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Cks1 is critical for Bcr-Abl (show ABL1 Proteins)-induced cytokine-independent clonogenic activity.
show that CKS2 counteracts CKS1 and stabilizes p27 (show CDKN1B Proteins)
Cks1 is overexpressed in various B cell malignancies, is required for tumor cell proliferation but is not sufficient to induce hematopoietic malignancies.
establish p27(Kip1 (show CDKN1B Proteins))-independent functions of Cks1 in regulating the G(1)-S transition
Collectively, these findings suggest that Cks1 targets, in addition to p27(Kip1 (show CDKN1B Proteins)), are critical for Myc (show MYC Proteins)-driven proliferation and tumorigenesis.
FGFR (show FGFR2 Proteins) kinase regulates the cell cycle through phosphorylation-dependent release of Cks1 from FGFR substrate 2 (show FRS2 Proteins)
Elevated expression of Cks1 may contribute to prostate tumorigenesis by promoting proliferation, anchorage-independent growth and migration of the cells, and elevated expression of Cks2 by protecting cells from undergoing programmed cell death.
Data show that cyclin-dependent kinase-associated proteins Cks1 and Cks2 are essential during early embryogenesis and for cell cycle progression in somatic cells.
we overexpressed CKS1B in multiple cell lines and found increased sensitivity to PLK1 knockdown and PLK1 drug inhibition. Finally, combined inhibition of WEE1 and PLK1 results in less apoptosis than predicted based on an additive model of the individual inhibitors, showing an epistatic interaction and confirming a prediction of the yeast data.
High expression of Cks1 was significantly associated with lymph node metastasis and survival status in nasopharyngeal carcinoma
Results show that Cks1 and Cks2 promoted proliferation and prevented apoptosis of hepatocellular carcinoma HepG2 cells.
Specifically, CKS1B and MAP2K5 (show MAP2K5 Proteins) significantly inhibited hepatitis C viral RNA replication. PACSIN1 (show PACSIN1 Proteins), by contrast, inhibited hepatitis C virus infection by decreasing the level of viral protein p7.
Regulation of Cks1 protein stability is crucially dependent on specific tyrosine and lysine residues which are potential sites for post-translational modifications.
We conclude that perturbing the Hsp90 pathway could provide a useful therapeutic strategy in tumors driven by Cks1 overexpression
Our results suggest a role for CKS1B in the multiple step process of progression of MGUS to MM and show that CKS1B copy gain has a more significant prognostic value than its overexpression.
EGF (show EGF Proteins) upregulates the mRNA and protein levels of Skp2/Cks1 and p27(kip1 (show CDKN1B Proteins)) via the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway and direct binding of E2F1 transcription factor (show E2F1 Proteins) with the Skp2 promoter in extrahepatic cholangiocarcinoma cells.
CKS1 mRNA and protein expression were increased in esophageal carcinoma. Overexpression of CKS1 was associated with higher grad, regional lymph node invasion, and neoplastic embolus. CKS1 was negatively associated with the p27(kip1 (show CDKN1B Proteins)) level in the tumor.
We demonstrated that high expression of CKS1B immunostaining can be one potent prognostic factor for disease-specific survival, metastasis-free survival, and local recurrence-free survival in patients with nasopharyngeal carcinoma.
CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein. At least two transcript variants have been identified for this gene, and it appears that only one of them encodes a protein.
cyclin-dependent kinases regulatory subunit 1
, CDC28 protein kinase regulatory subunit 1B
, CDC28 protein kinase regulatory subunit 1B-A
, CDC28 protein kinase regulatory subunit 1B-B
, CDC28 protein kinase 1B
, cyclin-dependent kinase regulatory subunit 1
, sid 1334
, CDC2-associated protein CKS1
, CDC28 protein kinase 1
, NB4 apoptosis/differentiation related protein
, cell division control protein CKS1
, CDC28 protein kinase regulatory subunit 1