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Histone H3 (show HIST3H3 Proteins) lysine 9 (H3K9) acetylation was most prevalent when the Dbf4 transcription level was highest whereas the H3K9me3 level was greatest during and just after replication.
we propose that phosphorylation of TOP2A (show TOP2A Proteins) by CDC7 (show CDC7 Proteins)/DBF4 in early S-phase prevents its localization and/or activity at centromeres, and inhibition of TOP2A (show TOP2A Proteins) function could be relevant to prevent premature separation of centromeric DNA.
The anti-invasive and cell cycle arrest-inducing effects of nitrogen-containing bisphosphonates are not DBF4 mediated in human breast cancer cells.
Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint.
bipartite interaction between Cdc7 (show CDC7 Proteins) and Dbf4/ASK subunits facilitates ATP binding and substrate recognition by the Cdc7 (show CDC7 Proteins) kinase.
Dbf4 regulates the Cdc5 Polo-like kinase through a distinct non-canonical binding interaction
Data document the role of DBF4 as a key player in nitrogen-containing bisphosphonate-induced cytotoxicity, thus explaining the effects on the cell-cycle.
The interaction with LEDGF (show PSIP1 Proteins) relieves autoinhibition of Cdc7 (show CDC7 Proteins)-ASK kinase, imposed by the C terminus of ASK.
results suggest that E2F (show E2F1 Proteins) regulates the ASK promoter through an atypical mode of recognition of the target site
The HuDbf4 gene has of 12 exons over a 33-kb region. The MluI cell-cycle box is needed for core promoter activation. The Sp1 upregulator & HES-1 repressor coordinately determine promoter efficiency. Transcription initiations occur at -220, -235 and -245.
Regulatory subunit for cdc7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Not required during the initiation of DNA replication in egg and during early embryonic development but is required later and throughout development. The complex cdc7-dbf4a phosphorylates mcm2 subunit.
DBF4 homolog (S. cerevisiae)
, DBF4 homolog B (S. cerevisiae)
, activator of S phase kinase
, protein DBF4 homolog A
, protein DBF4 homolog A-like
, DBF4-type zinc finger-containing protein 1
, chiffon homolog A
, zinc finger, DBF-type containing 1