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anti-Human DYRK1A Antibodies:
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Human Monoclonal DYRK1A Primary Antibody for ELISA, WB - ABIN560675
Aranda, Alvarez, Turró, Laguna, de la Luna: Sprouty2-mediated inhibition of fibroblast growth factor signaling is modulated by the protein kinase DYRK1A. in Molecular and cellular biology 2008
Show all 39 Pubmed References
Human Polyclonal DYRK1A Primary Antibody for WB - ABIN1881275
Park, Oh, Yoo, Jung, Song, Lee, Seo, Chung: Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells. in The Journal of biological chemistry 2010
Show all 4 Pubmed References
we suggest that de novo dominant mutations in DYRK1A account for nearly 0.5% of severe developmental disorders due to substantially reduced kinase function
The data described herein provide the first identification of a DYRK1A-mediated site of phosphorylation on GLI1 (show GLI1 Antibodies) within its NLS (show ALDH1A2 Antibodies) and may serve as a valuable mechanism for further understanding Hh signaling modulation.
DYRK1A phosphorylation of NFATc1/alphaA at S261, S278, S403 and S409 interfered with NFATc1 ubiquitination and ubiquitin-proteasome degradation.
These results suggest that TT genotype derived from SNP rs8126696 of DYRK1A gene is a possible risk factor for sporadic Parkinson disease, especially for males in this Chinese Han population.
identified the significant associations of the GBA (show GBA Antibodies) L444P mutation and DYRK1A rs8126696 T allele with the earlier age at onset (AAO) in Parkinson's disease (PD) patients, and the A allele at MS4A6A (show MS4A6A Antibodies) rs610932 with the delayed AAO of PD.
study uncovered a new regulatory mechanism of DYRK1A degradation by SCF (show KITLG Antibodies)(betaTrCP (show BTRC Antibodies)) in HEK293 cell cycle progression.
Identify Dyrk1a as a novel negative regulator of D-cyclin (show PCNA Antibodies)-mediated Rb1 (show RB1 Antibodies)/E2f (show E2F1 Antibodies)-signalling. As dysregulation of this pathway with impaired cardiomyocyte proliferation leads to cardiomyopathy.
The deleterious effect of DYRK1A triplication in the formation of the cerebral cortex begins at the onset of neurogenesis, which is relevant to the search for early therapeutic interventions in Down syndrome.
mutations in DYRK1A define a syndromic form of autism spectrum disorder and intellectual disability with neurodevelopmental defects consistent with murine and Drosophila knockout models
Cyclin D1 (show CCND1 Antibodies) Again Caught in the Act: Dyrk1a Links G1 and Neurogenesis in Down Syndrome.
Taken together, these results strongly suggested that DYRK1A bound to CDKL5 (show CDKL5 Antibodies) and phosphorylated it on Ser (show SIGLEC1 Antibodies)-308, thus interfering with its nuclear localization.
study identifies DYRK1A-STAT (show STAT1 Antibodies) as a signaling pathway responsible for the differentiation of neural progenitors into astrocytes, with direct implication for the anomalies in brain development observed in Down syndrome
This study identified decreased neuronal firing rate and deficits in gamma frequency in the prefrontal cortices of transgenic mice overexpressing Dyrk1A.
Increased Dyrk1a gene dosage is a major contributing factor to the abnormal appendicular skeletal phenotype observed in adolescent Ts65Dn Down syndrome mice.
the increased immunostaining of DYRK1A in HIV+ brains without pathology points at dysregulation of DYRK1A as an early event in the neuronal complications of HIV infection.
Our results identify DYRK1A as a physiologically relevant regulator of Treg cell differentiation and suggest a broader role for other DYRK family members in immune homeostasis.
these data suggest that the dosage imbalance of genes other than Dyrk1a is involved in the development of the prenatal bone phenotype in Ts65Dn embryos.
Show the crucial role of the DYRK1A pathway in the regulation of beta cell mass and carbohydrate metabolism in vivo. Activating the DYRK1A pathway could thus represent an innovative way to increase functional beta cell mass.
DYRK1A has a role in lymphopoiesis; Cyclin D3 (show CCND3 Antibodies) protein stability is negatively regulated during exit from the proliferative phases of B and T cell development
Dyrk1A positively and selectively modulates p120-catenin (show CTNND1 Antibodies) protein levels, thus having an impact on p120-catenin (show CTNND1 Antibodies) and Kaiso (show ZBTB33 Antibodies) (and canonical Wnt (show WNT2 Antibodies)) gene targets such as siamois and wnt11.
This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
, dual specificity tyrosine-phosphorylation-regulated kinase 1A
, protein kinase minibrain homolog
, dual specificity tyrosine-phosphorylation-regulated kinase 1A-like
, MNB/DYRK protein kinase
, dual specificity YAK1-related kinase
, mnb protein kinase homolog hp86
, serine/threonine kinase MNB
, serine/threonine-specific protein kinase
, Dual Specificity Yak1-related kinase
, minibrain protein kinase
, Protein kinase minibrain homolog