Browse our DYRK1A Proteins (DYRK1A)

Full name:
Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A Proteins (DYRK1A)
On www.antibodies-online.com are 8 Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) Proteins from 5 different suppliers available. Additionally we are shipping DYRK1A Antibodies (133) and DYRK1A Kits (8) and many more products for this protein. A total of 162 DYRK1A products are currently listed.
Synonyms:
2310043O08Rik, D16Ertd272e, D16Ertd493e, Dyrk, DYRK1, DYRK1A, ENSMUSG00000074897, Gm10783, HP86, mmb, MNB, Mnbh, Mp86, MRD7, PSK47
list all proteins Gene Name GeneID UniProt
DYRK1A 1859 Q13627
DYRK1A 13548 Q61214
Rat DYRK1A DYRK1A 25255 Q63470

Show all synonyms

DYRK1A Proteins (DYRK1A) by Origin

Select your origin of interest

More Proteins for DYRK1A Interaction Partners

Human Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) interaction partners

  1. we suggest that de novo dominant mutations in DYRK1A account for nearly 0.5% of severe developmental disorders due to substantially reduced kinase function

  2. The data described herein provide the first identification of a DYRK1A-mediated site of phosphorylation on GLI1 (show GLI1 Proteins) within its NLS (show ALDH1A2 Proteins) and may serve as a valuable mechanism for further understanding Hh signaling modulation.

  3. DYRK1A phosphorylation of NFATc1/alphaA at S261, S278, S403 and S409 interfered with NFATc1 ubiquitination and ubiquitin-proteasome degradation.

  4. These results suggest that TT genotype derived from SNP rs8126696 of DYRK1A gene is a possible risk factor for sporadic Parkinson disease, especially for males in this Chinese Han population.

  5. identified the significant associations of the GBA (show GBA Proteins) L444P mutation and DYRK1A rs8126696 T allele with the earlier age at onset (AAO) in Parkinson's disease (PD) patients, and the A allele at MS4A6A (show MS4A6A Proteins) rs610932 with the delayed AAO of PD.

  6. study uncovered a new regulatory mechanism of DYRK1A degradation by SCF (show KITLG Proteins)(betaTrCP (show BTRC Proteins)) in HEK293 cell cycle progression.

  7. Identify Dyrk1a as a novel negative regulator of D-cyclin (show PCNA Proteins)-mediated Rb1 (show RB1 Proteins)/E2f (show E2F1 Proteins)-signalling. As dysregulation of this pathway with impaired cardiomyocyte proliferation leads to cardiomyopathy.

  8. The deleterious effect of DYRK1A triplication in the formation of the cerebral cortex begins at the onset of neurogenesis, which is relevant to the search for early therapeutic interventions in Down syndrome.

  9. mutations in DYRK1A define a syndromic form of autism spectrum disorder and intellectual disability with neurodevelopmental defects consistent with murine and Drosophila knockout models

  10. Cyclin D1 (show CCND1 Proteins) Again Caught in the Act: Dyrk1a Links G1 and Neurogenesis in Down Syndrome.

Mouse (Murine) Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) interaction partners

  1. Taken together, these results strongly suggested that DYRK1A bound to CDKL5 (show CDKL5 Proteins) and phosphorylated it on Ser (show SIGLEC1 Proteins)-308, thus interfering with its nuclear localization.

  2. Identify Dyrk1a as a novel negative regulator of D-cyclin (show PCNA Proteins)-mediated Rb1 (show RB1 Proteins)/E2f (show E2F1 Proteins)-signalling. As dysregulation of this pathway with impaired cardiomyocyte proliferation leads to cardiomyopathy.

  3. study identifies DYRK1A-STAT (show STAT1 Proteins) as a signaling pathway responsible for the differentiation of neural progenitors into astrocytes, with direct implication for the anomalies in brain development observed in Down syndrome

  4. This study identified decreased neuronal firing rate and deficits in gamma frequency in the prefrontal cortices of transgenic mice overexpressing Dyrk1A.

  5. Increased Dyrk1a gene dosage is a major contributing factor to the abnormal appendicular skeletal phenotype observed in adolescent Ts65Dn Down syndrome mice.

  6. the increased immunostaining of DYRK1A in HIV+ brains without pathology points at dysregulation of DYRK1A as an early event in the neuronal complications of HIV infection.

  7. Our results identify DYRK1A as a physiologically relevant regulator of Treg cell differentiation and suggest a broader role for other DYRK family members in immune homeostasis.

  8. these data suggest that the dosage imbalance of genes other than Dyrk1a is involved in the development of the prenatal bone phenotype in Ts65Dn embryos.

  9. Show the crucial role of the DYRK1A pathway in the regulation of beta cell mass and carbohydrate metabolism in vivo. Activating the DYRK1A pathway could thus represent an innovative way to increase functional beta cell mass.

  10. DYRK1A has a role in lymphopoiesis; Cyclin D3 (show CCND3 Proteins) protein stability is negatively regulated during exit from the proliferative phases of B and T cell development

Xenopus laevis Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) interaction partners

  1. Dyrk1A positively and selectively modulates p120-catenin (show CTNND1 Proteins) protein levels, thus having an impact on p120-catenin (show CTNND1 Proteins) and Kaiso (show ZBTB33 Proteins) (and canonical Wnt (show WNT2 Proteins)) gene targets such as siamois and wnt11.

DYRK1A Protein Profile

Protein Summary

This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.

Alternative names and synonyms associated with DYRK1A

  • dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A)
  • dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (dyrk1a)
  • dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a (Dyrk1a)
  • dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (Dyrk1a)
  • 2310043O08Rik protein
  • D16Ertd272e protein
  • D16Ertd493e protein
  • Dyrk protein
  • DYRK1 protein
  • DYRK1A protein
  • ENSMUSG00000074897 protein
  • Gm10783 protein
  • HP86 protein
  • mmb protein
  • MNB protein
  • Mnbh protein
  • Mp86 protein
  • MRD7 protein
  • PSK47 protein

Protein level used designations for DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A , dual specificity tyrosine-phosphorylation-regulated kinase 1A , minibrain , protein kinase minibrain homolog , dual specificity tyrosine-phosphorylation-regulated kinase 1A-like , MNB/DYRK protein kinase , dual specificity YAK1-related kinase , hMNB , mnb protein kinase homolog hp86 , serine/threonine kinase MNB , serine/threonine-specific protein kinase , Dual Specificity Yak1-related kinase , MNBH , RP86 , minibrain protein kinase , Protein kinase minibrain homolog

GENE ID SPECIES
100051707 Equus caballus
458545 Pan troglodytes
693812 Macaca mulatta
779733 Xenopus (Silurana) tropicalis
100019775 Monodelphis domestica
100078677 Ornithorhynchus anatinus
100389032 Callithrix jacchus
100479774 Ailuropoda melanoleuca
100562279 Anolis carolinensis
100601498 Nomascus leucogenys
1859 Homo sapiens
13548 Mus musculus
25255 Rattus norvegicus
100350296 Oryctolagus cuniculus
395233 Gallus gallus
100514684 Sus scrofa
446302 Xenopus laevis
487755 Canis lupus familiaris
532989 Bos taurus
Selected quality suppliers for DYRK1A Proteins (DYRK1A)
Did you look for something else?