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Browse our FBXO5 Proteins (FBXO5)

Full name:
F-Box Protein 5 Proteins (FBXO5)
On are 5 F-Box Protein 5 (FBXO5) Proteins from 3 different suppliers available. Additionally we are shipping FBXO5 Antibodies (67) and FBXO5 Kits (12) and many more products for this protein. A total of 88 FBXO5 products are currently listed.
2510044I10Rik, ACYPI007854, C85305, Emi1, FBX5, Fbxo5, Fbxo31, fc65h02, wu:fc65h02, wu:fe06e07, wu:fz79f03, zgc:136397, zgc:158541
list all proteins Gene Name GeneID UniProt
FBXO5 26271 Q9UKT4
FBXO5 67141 Q7TSG3
Rat FBXO5 FBXO5 292263  

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FBXO5 Proteins (FBXO5) by Origin

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Human F-Box Protein 5 (FBXO5) interaction partners

  1. Examined eoffect of Emi1 over-expression on Skp2 expression in breast cancer. Found expression of Emi1 was positively related with Skp2 expression; Emi1 expression correlated significantly with histologic grade. Skp2 expression obtained similar results.

  2. Human papillomavirus type 16 E7 expression causes increased EMI1 mRNA expression and also inhibits EMI1 degradation.

  3. The C-terminal domain inhibits multiple APC/C(CDH1) functions. The intrinsically disordered D-box, linker & tail elements, & a structured Zn-binding domain synergistically block the substrate-binding site & inhibit ubiquitin-chain elongation.

  4. Emi1 depletion enhances the sensitivity of cancer cells to doxorubicin and x-ray irradiation.

  5. Emi1 expression (>5%) was seen in 23.3% of ovarian clear cell carcinoma, and associated with high FIGO grades and poor overall survival

  6. Emi1 participates in human hepatocellular carcinoma (HCC (show FAM126A Proteins)) cell proliferation and that progression is controlled by anaphase-promoting complex/cyclosome (APC (show APC Proteins)/C) inhibition, which stabilized Skp2 and enabled p27(kip1 (show CDKN1B Proteins)) degradation.

  7. the ability of Emi1 to inhibit APC (show APC Proteins)/C is negatively regulated by CDKs

  8. Results suggest that Bcr-Abl increases Emi1 phosphorylation and stability to prevent Skp2 protein degradation via APC/Cdh1-induced ubiquitination and to enhance proliferation of CML cells.

  9. These data suggest that E2F (show E2F1 Proteins) can activate both transcription of cyclin A (show CCNA2 Proteins) and the hEmi1-dependent stabilization of APC (show APC Proteins)(Cdh1 (show CDH1 Proteins)) targets, such as cyclin A (show CCNA2 Proteins), to promote S phase entry.

  10. Plk1 activates the anaphase promoting complex by directing the SCF-dependent destruction of Emi1 in prophase

Zebrafish F-Box Protein 5 (FBXO5) interaction partners

  1. These data indicate that emi1 deficiency-induced defects in vivo are due to the dysregulation of an APC/C-Cdh1 (show CDH1 Proteins) molecular axis.

  2. harpy/Rca1/emi1 has a role in patterning in the absence of cell division

  3. Emi1 is a critical regulator of genomic fidelity during embryogenesis.

FBXO5 Protein Profile

Protein Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with FBXO5

  • F-box protein 5 (FBXO5)
  • F-box protein 5 (fbxo5)
  • F-box only protein 5 (Fbxo5)
  • F-box protein 5 (Fbxo5)
  • 2510044I10Rik protein
  • ACYPI007854 protein
  • C85305 protein
  • Emi1 protein
  • FBX5 protein
  • Fbxo5 protein
  • Fbxo31 protein
  • fc65h02 protein
  • wu:fc65h02 protein
  • wu:fe06e07 protein
  • wu:fz79f03 protein
  • zgc:136397 protein
  • zgc:158541 protein

Protein level used designations for F-Box Protein 5 Proteins (FBXO5)

F-box only protein 5 , F-box protein Fbx5 , early mitotic inhibitor 1 , f-box only protein 31 , harpy , hrp , rca1

463083 Pan troglodytes
515080 Bos taurus
733555 Xenopus (Silurana) tropicalis
100167030 Acyrthosiphon pisum
26271 Homo sapiens
67141 Mus musculus
292263 Rattus norvegicus
612020 Canis lupus familiaris
445392 Danio rerio
101103731 Ovis aries
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