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interplay between MATalpha1, c-Myc (show MYC ELISA Kits), and Maf (show MAF ELISA Kits) proteins, and their deregulation during chronic cholestasis may facilitate cholangiocarcinoma oncogenesis
Of the 22 single nucleotide polymorphisms studied, the rs8193 polymorphism lying in the micro-RNA binding site of 3'-UTR (show UTS2R ELISA Kits) of CD44 (show CD44 ELISA Kits) was significantly (P=.0270) associated with RT-induced adverse skin reactions. Generalized multifactor dimensionality reduction analysis showed significant (P=.0107) gene-gene interactions between MAT1A and CD44 (show CD44 ELISA Kits).
A compound mutation of the methionine adenosyltransferase 1A (MAT1A) gene, c.345delA and c.529C>T, was identified in the patient, and His father and mother were found to be heterozygous for the c.345delA mutation and c.529C>T mutation, respectively.
S-adenosyl-L-methionine (show AS3MT ELISA Kits) diminishes hepatitis C virus expression by altering MAT1A/2A signaling in hepatocytes.
5-Aza-CdR (show RUNX1T1 ELISA Kits) showed no effects on MAT2A (show MAT2A ELISA Kits) methylation.
The mutations in the other 10 patients showed autosomal recessive inheritance and included eight novel MAT1A mutations.
Liver-specific isoenzyme MAT1A is genetically linked with an inborn metabolic disorder of hypermethioninemia, as well as a ubiquitously expressed isoenzyme MAT2A (show MAT2A ELISA Kits), whose enzymatic activity is regulated by an associated subunit MAT2B (show MAT2B ELISA Kits).
Methionine adenosyltransferase I/III deficiency is caused by mutations in the MAT1A gene. (Review)
upregulation of miR (show MLXIP ELISA Kits)-664, miR (show MLXIP ELISA Kits)-485-3p, and miR (show MLXIP ELISA Kits)-495 contributes to lower MAT1A expression in HCC (show FAM126A ELISA Kits), and enhanced tumorigenesis may provide potential targets for HCC (show FAM126A ELISA Kits) therapy.
Report SNPs that are highly associated with hepatic GNMT (show GNMT ELISA Kits) protein expression and the coordinate regulation of MAT1A levels.
MAT1A is required for normal VLDL assembly and plasma lipid homeostasis in mice. Impaired VLDL synthesis, mainly due to SAMe deficiency, contributes to NAFLD (show TSC2 ELISA Kits) development in MAT1A-KO mice.
Deletion of the TFIIH kinase subunit Mat1 in mouse fibroblasts leads to dramatically reduced RNA polymerase II Ser5 phosphorylation.
DUSP1 (show DUSP1 ELISA Kits) mRNA and protein levels are lower in Mat1a knockout livers and fall rapidly in cultured hepatocytes.
investigated the function of the Cdk7 (show CDK7 ELISA Kits).cyclin (show PCNA ELISA Kits) H.Mat1 complex in murine embryonic stem (ES) cells and preimplantation embryos to determine whether it regulates the unique cell cycle structure and transcriptional network of pluripotent cells
Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A
MAT1A knockout hepatocytes have more baseline DNA synthesis but no mitogenic response to hepatocyte growth factor (show HGF ELISA Kits). MAT1A-produced SAMe has a major role in ERK (show EPHB2 ELISA Kits) signaling & cyclin D1 (show CCND1 ELISA Kits) regulation during liver regeneration & mitogenic signal response.
Mat1a(-/-) mice have expansion of liver stem cells as they age. These cells have increased expression of several oncogenes and are tumorigenic in vivo.
C/EBPbeta (show CEBPB ELISA Kits) plays an important role in epigenetic regulation of the mature hepatic gene MAT1A
By 1 month of age, genomic instability increases in livers of Mat1a knockout mice, possibly due to reduced APEX1 (show APEX1 ELISA Kits) levels
This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency.
, S-adenosylmethionine synthase isoform type-1
, S-adenosylmethionine synthetase isoform type-1
, adoMet synthase 1
, adoMet synthetase 1
, methionine adenosyltransferase 1
, methionine adenosyltransferase I/III
, CDK-activating kinase assembly factor MAT1
, CDK7/cyclin H assembly factor
, CDK7/cyclin-H assembly factor
, RING finger protein MAT1
, S - adenosylmethionine synthetase