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interplay between MATalpha1, c-Myc (show MYC Proteins), and Maf (show MAF Proteins) proteins, and their deregulation during chronic cholestasis may facilitate cholangiocarcinoma oncogenesis
MAT1A is required for normal VLDL assembly and plasma lipid homeostasis in mice. Impaired VLDL synthesis, mainly due to SAMe deficiency, contributes to NAFLD development in MAT1A-KO mice.
Deletion of the TFIIH kinase subunit Mat1 in mouse fibroblasts leads to dramatically reduced RNA polymerase II Ser5 phosphorylation.
DUSP1 (show DUSP1 Proteins) mRNA and protein levels are lower in Mat1a knockout livers and fall rapidly in cultured hepatocytes.
investigated the function of the Cdk7 (show CDK7 Proteins).cyclin (show PCNA Proteins) H.Mat1 complex in murine embryonic stem (ES) cells and preimplantation embryos to determine whether it regulates the unique cell cycle structure and transcriptional network of pluripotent cells
This study demonstrates a requirement for MAT1 in the operation of PGC-1 coactivators that control cell metabolism.
study found that Mat1 and Cdk7 (show CDK7 Proteins) levels are undetectable in adipose tissues in vivo and downregulated during adipogenesis
Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A
MAT1A knockout hepatocytes have more baseline DNA synthesis but no mitogenic response to hepatocyte growth factor (show HGF Proteins). MAT1A-produced SAMe has a major role in ERK (show EPHB2 Proteins) signaling & cyclin D1 (show CCND1 Proteins) regulation during liver regeneration & mitogenic signal response.
Mat1a(-/-) mice have expansion of liver stem cells as they age. These cells have increased expression of several oncogenes and are tumorigenic in vivo.
PEA15 (show PEA15 Proteins) expression was not significantly correlated with ovarian cancer antineoplastic drug resistance.
Of the 22 single nucleotide polymorphisms studied, the rs8193 polymorphism lying in the micro-RNA binding site of 3'-UTR of CD44 (show CD44 Proteins) was significantly (P=.0270) associated with RT-induced adverse skin reactions. Generalized multifactor dimensionality reduction analysis showed significant (P=.0107) gene-gene interactions between MAT1A and CD44 (show CD44 Proteins).
A compound mutation of the methionine adenosyltransferase 1A (MAT1A) gene, c.345delA and c.529C>T, was identified in the patient, and His father and mother were found to be heterozygous for the c.345delA mutation and c.529C>T mutation, respectively.
S-adenosyl-L-methionine (show AS3MT Proteins) diminishes hepatitis C virus expression by altering MAT1A/2A signaling in hepatocytes.
Data suggest the role of the phospholipase C epsilon-Protein kinase D (show PRKD1 Proteins)-PEA15 (show PEA15 Proteins) protein-ribosomal S6 kinase (show RPS6KB1 Proteins)-IkappaB-NF-kappa B (show NFKB1 Proteins) pathway in facilitating inflammation and inflammation-associated carcinogenesis in the colon.
Integrin alpha5beta1 and p53 (show TP53 Proteins) convergent pathways in the control of anti-apoptotic proteins PEA-15 (show PEA15 Proteins) and survivin (show BIRC5 Proteins) in high-grade glioma.
High PED expression is associated with esophageal carcinoma.
The nuclear translocation of SApErk1/ 2 apart from PEA-15 (show PEA15 Proteins) as an important mechanism to reverse senescence phenotype.
Latent HCMV infection of CD34 (show CD34 Proteins) + cells protects cells from FAS (show FAS Proteins)-mediated apoptosis through the cellular IL-10 (show IL10 Proteins)/PEA-15 (show PEA15 Proteins) pathway.
This gene encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. Studies using knockout mice suggest that this protein may protect astrocytes from TNF-induced apoptosis. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake.
CDK-activating kinase assembly factor MAT1
, CDK7/cyclin H assembly factor
, CDK7/cyclin-H assembly factor
, RING finger protein MAT1
, S-adenosylmethionine synthase isoform type-1
, MAT 1
, S-adenosylmethionine synthetase isoform type-1
, adoMet synthase 1
, adoMet synthetase 1
, methionine adenosyltransferase 1
, methionine adenosyltransferase I/III
, S - adenosylmethionine synthetase
, 15 kDa phosphoprotein enriched in astrocytes
, Phosphoprotein enriched in astrocytes, 15kD
, astrocytic phosphoprotein PEA-15
, homolog of mouse MAT-1 oncogene
, phosphoprotein enriched in diabetes