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Additional support to the view that MCM8 mutations are involved in the primary ovarian insufficiency phenotype.
stalled replication forks can be restarted in S phase via homologous recombination using MCM8-9 as an alternative replicative helicase.
study showed that copy number increase and overexpression of MCM8 may play critical roles in human cancer development.
Significant number of potentially damaging and novel variants in MCM8 in primary ovarian insufficiency; multiallelic association with variants in DDR (show DDR1 ELISA Kits) and MCM8-MCM9 (show MCM9 ELISA Kits) interactome genes.
Novel mutations p. H317L and p. H601R in the MCM8 gene are potentially causative for primary ovarian insufficiency by dysfunctional DNA repair.
Suggest role for MCM8 in the pathogenesis of chronic myelogenous leukemia.
MCM8, a component of the pre-replication complex, is crucial for gonadal development and maintenance in humans-both males and females. These
An autosomal recessive ovarian failure disorder caused by an MCM8 mutation that manifests with endocrine dysfunction and genomic instability.
Chromatin immunoprecipitation analysis using human DR-GFP cells demonstrated that MCM8 and MCM9 (show MCM9 ELISA Kits) proteins are rapidly recruited to DNA damage sites and promote RAD51 (show RAD51 ELISA Kits) recruitment.
Single Nucleotide Polymorphism in MCM8 is associated with ovarian follicle number and menopause.
Mcm8 and Mcm9 (show MCM9 ELISA Kits) form a dimeric complex in Xenopus laevis egg extract that is not essential for DNA replication initiation.
MCM8 functions in the elongation step of DNA replication as a helicase (show DNA2 ELISA Kits) that facilitates the recruitment of RPA34 and stimulates the processivity of DNA polymerases at replication foci.
MCM8 and MCM9 (show MCM9 ELISA Kits) form a complex and that they coregulate their stability.
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described.
DNA helicase MCM8
, DNA replication licensing factor MCM8
, MCM8 minichromosome maintenance deficient 8
, REC homolog
, minichromosome maintenance 8
, minichromosome maintenance deficient 8
, Minichromosome maintenance 8