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Human MCM8 Protein expressed in Wheat germ - ABIN1310565
Henderson, Hall, Prpic, Hessling, Parker, Sampson, Simkins, Brough, Dixon, Lenz, Knapp, Murphy, Taylor, Fischer, Malinowski: The selection and characterization of antibodies to minichromosome maintenance proteins that highlight cervical dysplasia. in Journal of immunological methods 2011
Suggest role for MCM8 in the pathogenesis of chronic myelogenous leukemia.
MCM8, a component of the pre-replication complex, is crucial for gonadal development and maintenance in humans-both males and females. These
An autosomal recessive ovarian failure disorder caused by an MCM8 mutation that manifests with endocrine dysfunction and genomic instability.
Chromatin immunoprecipitation analysis using human DR-GFP cells demonstrated that MCM8 and MCM9 (show MCM9 Proteins) proteins are rapidly recruited to DNA damage sites and promote RAD51 (show RAD51 Proteins) recruitment.
Single Nucleotide Polymorphism in MCM8 is associated with ovarian follicle number and menopause.
Single nucleotide polymorphism in MCM8 is associated with menopause and the length of reproductive lifespan.
The MCM8 gene is located contrapodal to GCD10 at chromosome band 20p12.3-13.
MCM8 is a crucial component of the pre-RC and that the interaction between hMCM8 and hcdc6 is required for pre-RC assembly.
We find that MCM8, like MCM7 (show MCM7 Proteins), colocalizes on a specific DNA segment of the c-MYC (show MYC Proteins) replication initiation zone (c-MYC (show MYC Proteins) replicator) of DNA replications together with Cdc6 (show CDC6 Proteins) and cdk2 (show CDK2 Proteins), but differs with MCM7 (show MCM7 Proteins) in spatial relation to RPA70 (show RPA1 Proteins) during S phase.
Mcm8 and Mcm9 (show MCM9 Proteins) form a dimeric complex in Xenopus laevis egg extract that is not essential for DNA replication initiation.
MCM8 functions in the elongation step of DNA replication as a helicase that facilitates the recruitment of RPA34 and stimulates the processivity of DNA polymerases at replication foci.
MCM8 and MCM9 (show MCM9 Proteins) form a complex and that they coregulate their stability.
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described.
DNA helicase MCM8
, DNA replication licensing factor MCM8
, MCM8 minichromosome maintenance deficient 8
, REC homolog
, minichromosome maintenance 8
, minichromosome maintenance deficient 8
, Minichromosome maintenance 8