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anti-Rat (Rattus) ORC4 Antibodies:
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Cow (Bovine) Polyclonal ORC4 Primary Antibody for WB - ABIN2787391
Clarke, Clarke: DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system. in The Biochemical journal 2005
Human Polyclonal ORC4 Primary Antibody for ELISA, WB - ABIN256671
Vashee, Simancek, Challberg, Kelly: Assembly of the human origin recognition complex. in The Journal of biological chemistry 2001
Spotted-dick is a zinc-finger protein of Drosophila required for expression of Orc4 and S phase
compared with homozygous missense mutations, compound heterozygous mutations appeared to have a more severe effect on phenotype, causing more severe growth retardation in ORC4
identified three different mutations in the gene encoding ORC4, a component of the eukaryotic origin recognition complex, in five individuals with Meier-Gorlin syndrome
Study using HCT116 haplo-insufficient (show TGFb Antibodies) cells and Orc2 hypomorphic cells demonstrates that the binding of human Ku to replication origins precedes that of Orc-3 (show ORC3 Antibodies), -4, and -6 subunit binding.
describe 3 patients with B-cell lymphoproliferative disorders (2 with non-Hodgkin lymphoma and 1 with nonsecretory multiple myeloma) carrying a novel A286V mutation within ORC4L gene
ORC4 surrounds the chromatin that will be extruded in the polar body in both female meiotic divisions, then makes a transition from the cytoplasm to the chromosomes at zygotic anaphase, suggesting multiple roles for this replication licensing protein.
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. This gene encodes a subunit of the ORC complex. Several alternatively spliced transcript variants, some of which encode the same protein, have been reported for this gene.
, origin recognition complex subunit 4
, origin recognition complex, subunit 4
, origin recognition complex, subunit 4 homolog
, origin recognition complex, subunit 4-like