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anti-Mouse (Murine) PPP2R2A Antibodies:
anti-Human PPP2R2A Antibodies:
anti-Rat (Rattus) PPP2R2A Antibodies:
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Human Polyclonal PPP2R2A Primary Antibody for WB - ABIN1881683
Li, Cai, Shouse, Piluso, Liu: A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55. in The EMBO journal 2007
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Data suggest IGT10 mice, diabetes type 2 model, exhibit 2 genetic defects: haploinsufficiency (heterozygosity for null allele) of insulin receptor (Insr (show INSR Antibodies)); splice-site mutation in protein phosphatase 2 regulatory subunit B alpha (Ppp2r2a). Inheritance of either allele results in insulin (show INS Antibodies) resistance but not overt diabetes. Double heterozygosity leads to insulin (show INS Antibodies) resistance and diabetes type 2 without increase in body weight.
Concurrent mTORC1 inactivation and PP2A (show PPP2R2B Antibodies)-B55alpha stimulation fuel ULK1 (show ULK1 Antibodies)-dependent autophagy.
FBXL16 (show FBXL16 Antibodies) negatively regulates the activity of B55alpha-PP2A (show PPP2R2B Antibodies) to modulate the genesis of FLK1 (show KDR Antibodies)+ progenitor cells.
Ppp2r2a is required for Connexin-43 (show GJA1 Antibodies) dephosphorlyation during epidermal barrier acquisition
The B55alpha-EDD (show UBR5 Antibodies)-p53 (show TP53 Antibodies) pathway is essential for cancer cell survival and tumor growth under low glutamine (show GFPT1 Antibodies) conditions in vitro and in vivo.
that B55alpha-dependent targeting of the PP2A (show PPP2R2B Antibodies) holoenzyme to Akt (show AKT1 Antibodies) selectively regulates Akt (show AKT1 Antibodies) phosphorylation at Thr (show TRH Antibodies)-308 to regulate cell proliferation and survival.
PP-2A is less abundant than PP-1 (show PPP1CC Antibodies) in the mouse eye and appear to be highly regulated by various regulatory subunits; the genes encoding PP-1alpha/beta, PP-2Aalpha/beta, PP-2A-Aalpha/beta, and PP-2A-B alpha/beta/gamma are all differentially expressed.
results suggest that PR55alpha promotes pancreatic cancer development by sustaining hyperactivity of multiple oncogenic signaling pathways, including AKT (show AKT1 Antibodies), ERK (show EPHB2 Antibodies), and Wnt (show WNT2 Antibodies)
miR-222 targets protein phosphatase 2A subunit B in bladder cancer cells.
miR (show MLXIP Antibodies)-556-5p functions as an onco-miRNA and participates in prostate cancer carcinogenesis by suppressing PPP2R2A expression.
Concurrent mTORC1 inactivation and PP2A (show PPP2R4 Antibodies)-B55alpha stimulation fuel ULK1 (show ULK1 Antibodies)-dependent autophagy.
Data show that breast cancer (BC) with PPP2R2A deletions are associated with worse overall survival, and the combination of altered PPP2R2A and high CCND1 (show CCND1 Antibodies) expression define a subgroup of luminal-like BC patients with a high risk of relapse and death.
overexpression of miR (show MLXIP Antibodies)-892a may provide a selective growth promotion for colorectal cancer cells by direct suppression of PPP2R2A expression.
miR (show MLXIP Antibodies)-136 may play an important role during TGF-beta1 (show TGFB1 Antibodies)-induced proliferation arrest by targeting PPP2R2A in keratinocytes.
Data suggest livers of biliary atresia subjects exhibit overexpression of MIR222 (microRNA 222); this appears to contribute to liver fibrosis (and in vitro cell proliferation) by targeting PPP2R2A (protein phosphatase 2A subunit B) and Akt (show AKT1 Antibodies) signaling.
The suppression of B55alpha activates signaling pathways that could support leukemia cell survival.
Identification of the adenovirus E4orf4 protein binding site on the B55alpha and Cdc55 regulatory subunits of PP2A (show PPP2R4 Antibodies): Implications for PP2A (show PPP2R4 Antibodies)
Phosphorylation of T231 (AT180) can negatively influence the dephosphorylation of the pS202/pT205 AT8 epitope, even without an altered PP2A (show PPP2R2B Antibodies) pool.
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described.
PP2A subunit B isoform B55-alpha
, PP2A subunit B isoform PR55-alpha
, PP2A subunit B isoform R2-alpha
, PP2A subunit B isoform alpha
, serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
, protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform
, protein phosphatase 2 (formerly 2A), regulatory subunit B (PR52), alpha isoform
, serine/threonine protein phosphatase 2A, 55 KDA regulatory subunit B, alpha isoform
, PP2A subunit B isoform BRA
, PP2A, subunit B, B-alpha isoform
, PP2A, subunit B, B55-alpha isoform
, PP2A, subunit B, BRA isoform
, PP2A, subunit B, PR55-alpha isoform
, PP2A, subunit B, R2-alpha isoform
, protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform