Browse our PPP2R2A Proteins (PPP2R2A)

Full name:
Protein Phosphatase 2 Regulatory Subunit 2A Proteins (PPP2R2A)
On www.antibodies-online.com are 7 Protein Phosphatase 2 Regulatory Subunit 2A (PPP2R2A) Proteins from 3 different suppliers available. Additionally we are shipping PPP2R2A Antibodies (28) and many more products for this protein. A total of 36 PPP2R2A products are currently listed.
Synonyms:
2410004D02Rik, B55A, B55ALPHA, mKIAA1541, PPP2R2A, PR52A, PR55A
list all proteins Gene Name GeneID UniProt
PPP2R2A 71978 Q6P1F6
PPP2R2A 5520 P63151
PPP2R2A 117104 P36876

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PPP2R2A Proteins (PPP2R2A) by Origin

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More Proteins for PPP2R2A Interaction Partners

Mouse (Murine) Protein Phosphatase 2 Regulatory Subunit 2A (PPP2R2A) interaction partners

  1. Data suggest IGT10 mice, diabetes type 2 model, exhibit 2 genetic defects: haploinsufficiency (heterozygosity for null allele) of insulin receptor (Insr (show INSR Proteins)); splice-site mutation in protein phosphatase 2 regulatory subunit B alpha (Ppp2r2a). Inheritance of either allele results in insulin (show INS Proteins) resistance but not overt diabetes. Double heterozygosity leads to insulin (show INS Proteins) resistance and diabetes type 2 without increase in body weight.

  2. Concurrent mTORC1 inactivation and PP2A (show PPP2R2B Proteins)-B55alpha stimulation fuel ULK1 (show ULK1 Proteins)-dependent autophagy.

  3. FBXL16 (show FBXL16 Proteins) negatively regulates the activity of B55alpha-PP2A (show PPP2R2B Proteins) to modulate the genesis of FLK1 (show KDR Proteins)+ progenitor cells.

  4. Ppp2r2a is required for Connexin-43 (show GJA1 Proteins) dephosphorlyation during epidermal barrier acquisition

  5. The B55alpha-EDD-p53 pathway is essential for cancer cell survival and tumor growth under low glutamine conditions in vitro and in vivo.

  6. that B55alpha-dependent targeting of the PP2A (show PPP2R2B Proteins) holoenzyme to Akt (show AKT1 Proteins) selectively regulates Akt (show AKT1 Proteins) phosphorylation at Thr (show TRH Proteins)-308 to regulate cell proliferation and survival.

  7. PP-2A is less abundant than PP-1 (show PPP1CC Proteins) in the mouse eye and appear to be highly regulated by various regulatory subunits; the genes encoding PP-1alpha/beta, PP-2Aalpha/beta, PP-2A-Aalpha/beta, and PP-2A-B alpha/beta/gamma are all differentially expressed.

Human Protein Phosphatase 2 Regulatory Subunit 2A (PPP2R2A) interaction partners

  1. results suggest that PR55alpha promotes pancreatic cancer development by sustaining hyperactivity of multiple oncogenic signaling pathways, including AKT (show AKT1 Proteins), ERK (show EPHB2 Proteins), and Wnt (show WNT2 Proteins)

  2. miR-222 targets protein phosphatase 2A subunit B in bladder cancer cells.

  3. miR (show MLXIP Proteins)-556-5p functions as an onco-miRNA and participates in prostate cancer carcinogenesis by suppressing PPP2R2A expression.

  4. Concurrent mTORC1 inactivation and PP2A (show PPP2R4 Proteins)-B55alpha stimulation fuel ULK1 (show ULK1 Proteins)-dependent autophagy.

  5. Data show that breast cancer (BC) with PPP2R2A deletions are associated with worse overall survival, and the combination of altered PPP2R2A and high CCND1 (show CCND1 Proteins) expression define a subgroup of luminal-like BC patients with a high risk of relapse and death.

  6. overexpression of miR (show MLXIP Proteins)-892a may provide a selective growth promotion for colorectal cancer cells by direct suppression of PPP2R2A expression.

  7. miR (show MLXIP Proteins)-136 may play an important role during TGF-beta1 (show TGFB1 Proteins)-induced proliferation arrest by targeting PPP2R2A in keratinocytes.

  8. Data suggest livers of biliary atresia subjects exhibit overexpression of MIR222 (microRNA 222); this appears to contribute to liver fibrosis (and in vitro cell proliferation) by targeting PPP2R2A (protein phosphatase 2A subunit B) and Akt (show AKT1 Proteins) signaling.

  9. The suppression of B55alpha activates signaling pathways that could support leukemia cell survival.

  10. Identification of the adenovirus E4orf4 protein binding site on the B55alpha and Cdc55 regulatory subunits of PP2A (show PPP2R4 Proteins): Implications for PP2A (show PPP2R4 Proteins)

Rabbit Protein Phosphatase 2 Regulatory Subunit 2A (PPP2R2A) interaction partners

  1. Phosphorylation of T231 (AT180) can negatively influence the dephosphorylation of the pS202/pT205 AT8 epitope, even without an altered PP2A (show PPP2R2B Proteins) pool.

PPP2R2A Protein Profile

Protein Summary

The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described.

Alternative names and synonyms associated with PPP2R2A

  • protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform (Ppp2r2a)
  • protein phosphatase 2, regulatory subunit B, alpha (PPP2R2A)
  • protein phosphatase 2, regulatory subunit B, alpha (Ppp2r2a)
  • protein phosphatase 2A1 B alpha subunit (LOC100328616)
  • 2410004D02Rik protein
  • B55A protein
  • B55ALPHA protein
  • mKIAA1541 protein
  • PPP2R2A protein
  • PR52A protein
  • PR55A protein

Protein level used designations for PPP2R2A

PP2A subunit B isoform B55-alpha , PP2A subunit B isoform PR55-alpha , PP2A subunit B isoform R2-alpha , PP2A subunit B isoform alpha , serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform , protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform , protein phosphatase 2 (formerly 2A), regulatory subunit B (PR52), alpha isoform , serine/threonine protein phosphatase 2A, 55 KDA regulatory subunit B, alpha isoform , PP2A subunit B isoform BRA , PP2A, subunit B, B-alpha isoform , PP2A, subunit B, B55-alpha isoform , PP2A, subunit B, BRA isoform , PP2A, subunit B, PR55-alpha isoform , PP2A, subunit B, R2-alpha isoform , protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform

GENE ID SPECIES
71978 Mus musculus
508045 Bos taurus
5520 Homo sapiens
117104 Rattus norvegicus
100328616 Oryctolagus cuniculus
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