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Browse our anti-Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) (PSMB8) Antibodies

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anti-Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) Antibodies (PSMB8)
On www.antibodies-online.com are 71 Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) (PSMB8) Antibodies from 18 different suppliers available. Additionally we are shipping Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) Proteins (14) and Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) Kits (8) and many more products for this protein. A total of 101 Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) products are currently listed.
Synonyms:
ALDD, ATP6V0D2, D6S216, D6S216E, JMP, Lmp-7, LMP7, NKJO, PSMB5i, Ring10
list all antibodies Gene Name GeneID UniProt
PSMB8 16913 P28063
PSMB8 5696 P28062
PSMB8 24968 P28064

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Most Popular Reactivities for anti-Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) (PSMB8) Antibodies

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All available anti-Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) Antibodies

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Top referenced anti-Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) Antibodies

  1. Human Polyclonal PSMB8 Primary Antibody for ICC, IF - ABIN267107 : Meister, Frey, Lang, Gaipl, Schett, Schlötzer-Schrehardt, Voll: Calcium channel blocker verapamil enhances endoplasmic reticulum stress and cell death induced by proteasome inhibition in myeloma cells. in Neoplasia (New York, N.Y.) 2010 (PubMed)
    Show all 2 references for ABIN267107

  2. Human Monoclonal PSMB8 Primary Antibody for EIA, IF - ABIN1108774 : Mehta, Jordanova, Corver, van Wezel, Uh, Kenter, Jan Fleuren: Single nucleotide polymorphisms in antigen processing machinery component ERAP1 significantly associate with clinical outcome in cervical carcinoma. in Genes, chromosomes & cancer 2009 (PubMed)
    Show all 2 references for ABIN1108774

  3. Human Polyclonal PSMB8 Primary Antibody for ELISA, WB - ABIN4331261 : Schwarz, van Den Broek, Kostka, Kraft, Soza, Schmidtke, Kloetzel, Groettrup: Overexpression of the proteasome subunits LMP2, LMP7, and MECL-1, but not PA28 alpha/beta, enhances the presentation of an immunodominant lymphocytic choriomeningitis virus T cell epitope. in Journal of immunology (Baltimore, Md. : 1950) 2000 (PubMed)
    Show all 2 references for ABIN4331261

  4. Human Monoclonal PSMB8 Primary Antibody for ICC, IHC - ABIN969371 : Camarena, Aquino-Galvez, Falfán-Valencia, Sánchez, Montaño, Ramos, Juárez, García-de-Alba, Granados, Selman: PSMB8 (LMP7) but not PSMB9 (LMP2) gene polymorphisms are associated to pigeon breeder's hypersensitivity pneumonitis. in Respiratory medicine 2010 (PubMed)
    Show all 2 references for ABIN969371

  5. Human Monoclonal PSMB8 Primary Antibody for IF, IHC (p) - ABIN562483 : Nijholt, de Graaf, van Haastert, Oliveira, Berkers, Zwart, Ovaa, Baas, Hoozemans, Scheper: Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's disease. in Cell death and differentiation 2011 (PubMed)

  6. Human Monoclonal PSMB8 Primary Antibody for IF - ABIN393460 : Hamamura, Chen, Nishimura, Tanjung, Sudo, Yokota: Predicting and validating the pathway of Wnt3a-driven suppression of osteoclastogenesis. in Cellular signalling 2014 (PubMed)

  7. Cow (Bovine) Polyclonal PSMB8 Primary Antibody for EIA, WB - ABIN615902 : Deshpande, Wheeler, Hunt, Peyton, White, Valdez, Nolan: Variation in HLA class I antigen-processing genes and susceptibility to human papillomavirus type 16-associated cervical cancer. in The Journal of infectious diseases 2008 (PubMed)

More Antibodies against Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) Interaction Partners

Mouse (Murine) Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) (PSMB8) interaction partners

  1. LMP7 deficiency decreased inflammatory responses such as macrophage infiltration and chemokine (show CCL1 Antibodies) expression while it increased serum adiponection levels.

  2. these data support that LMP7 inhibition in the context of BMT modulates allogeneic responses by decreasing endogenous miHA (show XIAP Antibodies) presentation and that the consequential reduction in allogeneic stimulation and cytokine production reduces GVHD development.

  3. PSMB8, ALDH1A1 (show ALDH1A1 Antibodies), and HSPA4 (show HSPA4 Antibodies) were identified to be located in ovarian tissues, to regulate 12 cellular pathways, and demonstrate age-dependent dynamic changes in expression profiling.

  4. Overexpression of the immunoproteasome LMP7 subunit in antigen-presenting cells due to lipopolysaccharide exposure as well as LMP7 expression in peripheral cells, are required for CD8 (show CD8A Antibodies)+ T-cell auto-reactivity.

  5. Data show that knockdown of i-proteasome catalytic subunit PSMB9 (show PSMB9 Antibodies) by short hairpin RNA (shRNA) decreased the expression of both PSMB9 (show PSMB9 Antibodies) and PSMB8 without affecting other catalytic subunits of the proteasome.

  6. we present novel evidence for the requirement of the beta5i immunosubunit to generate a strong Th2 response during OVA- but not HDM (show HDAC3 Antibodies)-induced acute asthma.

  7. Red blood cells of LMP7-deficient mice were more likely to deform in response to infection with malaria parasites, presumably resulting in higher susceptibility to phagocytosis and in the partial resistance to malaria.

  8. Deletion or inhibition of LMP7 suppresses generation of T helper (Th)17 cells but promotes regulatory T cell (Treg) development.

  9. Probeta5 predominantly promotes integration into LMP2 (show PSMB9 Antibodies)/MECL-1 (show PSMB10 Antibodies)-containing precursors in IFNgamma-stimulated, LMP7-deficient cells and infected LMP7-deficient mice.

  10. LMP7 and MECL1 (show PSMB10 Antibodies) regulate cytokine expression, suggesting this system represents a novel mechanism for the regulation of cytokines and cytokine signaling

Human Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) (PSMB8) interaction partners

  1. Data show that tight junction protein 1 (TJP1 (show TJP1 Antibodies)) suppressed expression of the catalytically proteasome subunits LMP7 and LMP2 (show PSMB9 Antibodies), decreased proteasome activity, and enhanced proteasome inhibitor sensitivity in vitro and in vivo through suppression of EGFR (show EGFR Antibodies)/JAK1 (show JAK1 Antibodies)/STAT3 (show STAT3 Antibodies) signaling.

  2. there was no significant difference with respect to the genotypic frequencies of the SNPs in PSMB8, TAP1, and TAP2 loci in Parkinson's disease patients

  3. We described a Brazilian patient with CANDLE syndrome possessing a novel mutation in the PSMB8 gene.

  4. designed siRNAs that efficiently silence LMP2 (show PSMB9 Antibodies), LMP7 and MECL-1 (show PSMB10 Antibodies) gene expression.

  5. demonstrated that patients with the LMP-7 CA/AA genotypes were more likely to have advanced fibrosis scores than those bearing the CC genotype

  6. lupus nephritis showed up-regulation of the immunoproteasome subunit LMP7 in tubular epithelial cells associated with type I interferon (show IFNA Antibodies) signature.

  7. Comparison with reference profiles of sorted immune cells and healthy muscle confirmed upregulation of PSMB8 and -9 in myositis biopsies beyond infiltration related changes.

  8. The LMP7 gene promoter methylation and protein downregulation were correlated at high extent in Kazakh's ESCC patients, and may explain the epigenetic regulation on gene expression.

  9. In patients with primary Sjogren's syndrome, the expression of LMP7 (but not LMP2 (show PSMB9 Antibodies)) is up-regulated in the labial (show LAT2 Antibodies) gland.

  10. Data indicate that treatment-emergent resistance to single-agent bortezomib was independent of variants in the proteasome genes PSMB1 (show PSMB1 Antibodies), PSMB5 (show PSMB5 Antibodies), PSMB6 (show PSMB6 Antibodies), PSMB8, PSMB9 (show PSMB9 Antibodies), and PSMB10 (show PSMB10 Antibodies).

Pig (Porcine) Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) (PSMB8) interaction partners

  1. These results suggest LMP2 (show PSMB9 Antibodies)/LMP7 gene should be regarded as molecular marker to estimate animal's immune status for their effects on hematological traits.

Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) (PSMB8) Antigen Profile

Antigen Summary

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified\; both isoforms are processed to yield the same mature subunit.

Alternative names and synonyms associated with Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) (PSMB8)

  • proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) (Psmb8) antibody
  • proteasome (prosome, macropain) subunit, beta type, 8 (PSMB8) antibody
  • proteasome (prosome, macropain) subunit, beta type, 8 (Psmb8) antibody
  • proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) (PSMB8) antibody
  • ALDD antibody
  • ATP6V0D2 antibody
  • D6S216 antibody
  • D6S216E antibody
  • JMP antibody
  • Lmp-7 antibody
  • LMP7 antibody
  • NKJO antibody
  • PSMB5i antibody
  • Ring10 antibody

Protein level used designations for PSMB8

MC13 (LMP7) , large multifunctional protease 7 , low molecular mass protein 7 , macropain subunit C13 , multicatalytic endopeptidase complex subunit C13 , proteasome component C13 , proteasome subunit MC13 , proteasome subunit beta type-8 , proteasome subunit beta-5i , proteosome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) , proteosome beta 8 subunit , large multifunctional peptidase 7 , low molecular weight protein 7 , protease component C13 , proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) , proteasome catalytic subunit 3i , proteasome subunit Y2 , proteasome subunit beta 5i , proteasome-related gene 7 , really interesting new gene 10 protein , low molecular mass polypeptide 7 , proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) , MHC class II DO beta , proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional protease 7) , proteasome beta 8 subunit , proteasome subunit LMP7 , macropain , proteasome subunit, beta type 8

GENE ID SPECIES
16913 Mus musculus
5696 Homo sapiens
24968 Rattus norvegicus
474865 Canis lupus familiaris
396975 Sus scrofa
282013 Bos taurus
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