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anti-Mouse (Murine) PSMC5 Antibodies:
anti-Human PSMC5 Antibodies:
anti-Rat (Rattus) PSMC5 Antibodies:
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Human Monoclonal PSMC5 Primary Antibody for ChIP, IP - ABIN151810
Koues, Dudley, Mehta, Greer: The 19S proteasome positively regulates histone methylation at cytokine inducible genes. in Biochimica et biophysica acta 2009
Show all 4 Pubmed References
Human Polyclonal PSMC5 Primary Antibody for ICC, IF - ABIN251012
Koues, Dudley, Truax, Gerhardt, Bhat, McNeal, Greer: Regulation of acetylation at the major histocompatibility complex class II proximal promoter by the 19S proteasomal ATPase Sug1. in Molecular and cellular biology 2008
Study shows that chronic exposure to cocaine alters the nuclear levels of PSMC5, an ATPase (show DNAH8 Antibodies)-containing subunit of the 19S proteasomal complex, in the nucleus accumbens and that PSMC5 in turn controls behavioral responses to cocaine.
These results imply that a deficiency in 19S Rpt6 may be partially related to the MPTP (show PTPN2 PLURAL_@19415@)-induced increase in alpha-synuclein (show SNCA PLURAL_@19415@) in the striatum. (19S Rpt6)
Caspase-3 (show CASP3 Antibodies) cleaves specific 19 S proteasome subunits in skeletal muscle stimulating proteasome activity
autoinflammation-associated H443P nlrc4 (show NLRC4 Antibodies) mutant is altered in interaction with SUG1 and ubiquitinated proteins, triggering constitutive caspase-8 (show CASP8 Antibodies)-mediated cell death dependent on FADD (show FADD Antibodies) but independent of Ser (show SIGLEC1 Antibodies)(533) phosphorylation.
results demonstrate that PSMC5 is a new and important player involved in regulating ERK1/2 (show MAPK1/3 Antibodies) signal transmission through the remodeling of Shoc2 (show SHOC2 Antibodies) scaffold complex in a spatially-defined manner.
Our data suggest that PSMC5 facilitates the damaging effects of radiation in radiation-responsive H460 cancer cells and therefore may serve as a prognostic indicator for radiotherapy and molecular targeted therapy in lung cancer patients.
TRIP-1 regulates fibroblast acquisition of phenotype and function associated with myofibroblasts.
gamma-aminobutyric acidB receptor proteasomal degradation is mediated by the interaction of the GABAB2 C terminus with the proteasomal ATPase (show DNAH8 Antibodies) Rtp6 and regulated by neuronal activity
Rpt6 interacts directly with CKIP-1 (show PLEKHO1 Antibodies) and promotes the turnover of Smurf1 (show SMURF1 Antibodies).
Sug1 plays a critical role in transcription of MHC class I, and the MHC class II-like molecules, HLA-DM and HLA-DO.
Findings show that Sug1 is crucial for regulating histone H3K4me3 and H3R17me2 at the cytokine inducible MHC-II and CIITA (show CIITA Antibodies) promoters.
SUG1 has a role in ubiquitin/proteasome-mediated degradation of estrogen receptors
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene.
26S protease regulatory subunit 8
, 26S proteasome AAA-ATPase subunit RPT6
, proteasome 26S subunit ATPase 5
, proteasome subunit p45
, MSUG1 protein
, Tat-binding protein homolog 10
, proteasome 26S ATPase subunit 5
, thyroid hormone receptor-interacting protein 1
, thyroid receptor interactor 1
, for proteasomal ATPase (SUG1)
, peptidase (prosome, macropain) 26S subunit, ATPase 5
, protease (prosome, macropain) 26S subunit, ATPase 5
, proteasomal ATPase (SUG1)
, proteasome p45/SUG
, 26S protease subunit
, TAT-binding protein homolog 10
, SUG1 homolog