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the high-resolution solution structure of the UBL domain of human UBLCP1 (show UBLCP1 ELISA Kits) and its interaction with Rpn1
Results suggest that PSMD2 may be a good molecular target candidate.
These data suggest that p97 (show EIF4G2 ELISA Kits) recruits proteasomes to polytopic ER proteins, such as Insig-1 (show INSIG1 ELISA Kits), even before they are extracted from membranes.
U87 glioblastoma cells transduced to express the epidermal growth factor receptor (show EGFR ELISA Kits) vIII (show COX8A ELISA Kits) (EGFRvIII) mutant do not respond toirrradiation with 26s proteasome (show Psmd4 ELISA Kits) inhibition.
Data show that data provide a novel mechanism whereby CaMKII (show CAMK2G ELISA Kits) may regulate the proteasome in neurons to facilitate remodeling of synaptic connections through protein degradation.
the 26S proteasome (show Psmd4 ELISA Kits) may provide a general predictive biomarker for radiotherapy outcome.
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1.
26S proteasome regulatory subunit S2
, 26S proteasome non-ATPase regulatory subunit 2
, 26s proteasome regulatory subunit S2-like protein
, proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
, proteasome 26S non-ATPase subunit 2
, 55.11 protein
, TNFR-associated protein 2
, protein 55.11
, tumor necrosis factor type 1 receptor-associated protein 2
, 26S proteasome regulatory subunit RPN1
, 26S proteasome subunit p97
, testis expressed gene 190