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the critical role of S5b/PSMD5 in negative regulation of proteasome by TNF-alpha (show TNF Proteins)/NFkappaB (show NFKB1 Proteins) and provide insights into proteasome inhibition in human disease.
the critical role of S5b/PSMD5 in negative regulation of proteasome by TNF-alpha (show TNF Proteins)/NFkappaB and provide insights into proteasome inhibition in human disease.
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a non-ATPase subunit of the 19S regulator base that functions as a chaperone protein during 26S proteasome assembly.
26S protease subunit S5 basic
, 26S proteasome non-ATPase regulatory subunit 5
, 26S proteasome subunit S5B