Browse our PSME1 Proteins (PSME1)

Full name:
Proteasome (Prosome, Macropain) Activator Subunit 1 (PA28 Alpha) Proteins (PSME1)
On are 9 Proteasome (Prosome, Macropain) Activator Subunit 1 (PA28 Alpha) (PSME1) Proteins from 6 different suppliers available. Additionally we are shipping PSME1 Antibodies (69) and PSME1 Kits (1) and many more products for this protein. A total of 86 PSME1 products are currently listed.
AW413925, fk89d05, IFI5111, PA28a, PA28alpha, REGalpha, wu:fk89d05
list all proteins Gene Name GeneID UniProt
Rat PSME1 PSME1 29630  
PSME1 5720 Q06323
PSME1 19186 P97371

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PSME1 Proteins (PSME1) by Origin

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Top referenced PSME1 Proteins

  1. Human PSME1 Protein expressed in Escherichia coli (E. coli) - ABIN667239 : Ahn, Erlander, Leturcq, Peterson, Früh, Yang: In vivo characterization of the proteasome regulator PA28. in The Journal of biological chemistry 1996 (PubMed)
    Show all 2 references for 667239

More Proteins for PSME1 Interaction Partners

Human Proteasome (Prosome, Macropain) Activator Subunit 1 (PA28 Alpha) (PSME1) interaction partners

  1. Results show that PA28alpha was found to be overexpressed in oral squamous cell carcinoma cell lines and tumor tissues. High expression of PA28alpha was significantly associated with recurrence and poorer overall survival.

  2. Constitutive expression of PA28 and ERAP1 (show ERAP1 Proteins) in melanoma cells indicate that both interfere with MART-1 (show MLANA Proteins)(26-35) epitope generation even in the absence of IFN-gamma (show IFNG Proteins)

  3. PA28 selectively up-regulates the presentation of viral MHC class I epitopes and that down regulation PA28 in tumor cells results in impaired presentation of a human TRP2 (show DCT Proteins) tumor antigen.

  4. Impaired expression of proteasome subunits is involved in the loss of HLA class I (show MICA Proteins) expression in human colon cancer cells.

  5. The relationship between anti-PA28alpha and Ki antibodies suggests the importance of an antigen-driven system in the induction of an autoimmune response to PA28 complex.

  6. DJ-1 (show PARK7 Proteins) and PA28alpha may have roles in the onset of hepatocarcinogenesis

  7. the 11S proteasome activator complex, Reg alpha fragment, may have a role in ovarian cancer

Mouse (Murine) Proteasome (Prosome, Macropain) Activator Subunit 1 (PA28 Alpha) (PSME1) interaction partners

  1. Inhibiting accumulation of PA28alpha using microRNA counteracted the removal of damaged proteins demonstrating that PA28alphabeta has a role required for resetting the levels of protein damage at the transition from self-renewal to cell differentiation.

  2. Nrf2 (show NFE2L2 Proteins)-dependent induction of proteasome and Pa28alphabeta regulator are required for adaptation to oxidative stress.

  3. demonstrate that PA28 and the proteasome immunosubunits use fundamentally different mechanisms to enhance the supply of MHC class I-binding peptides

  4. the processing of antigens is regulated by two distinct pathways, one requiring PA28 and the other hsp90 (show HSP90 Proteins)

  5. In immature dendritic cells, the assembly of PA28 alpha beta complexes appears to be limited by the low expression of PA28 beta (show PSME2 Proteins), whereas PA28 alpha expression is already high.

PSME1 Protein Profile

Protein Summary

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Two transcripts encoding different isoforms have been identified.

Alternative names and synonyms associated with PSME1

  • proteasome activator subunit 1 (psme1)
  • proteasome activator subunit 1 (LOC100343673)
  • proteasome (prosome, macropain) activator subunit 1 (Psme1)
  • proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) (PSME1)
  • proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) (Psme1)
  • AW413925 protein
  • fk89d05 protein
  • IFI5111 protein
  • PA28a protein
  • PA28alpha protein
  • REGalpha protein
  • wu:fk89d05 protein

Protein level used designations for PSME1

proteasome activator complex subunit 1 , pA23-a , proteasome activator subunit 1 , 11S regulator complex subunit alpha , PA28a , PA28alpha , REG-alpha , activator of multicatalytic protease subunit 1 , protease (prosome, macropain) 28 subunit, alpha , proteasome (prosome, macropain) 28 subunit, alpha , proteasome activator 28 subunit alpha , 29-kD MCP activator subunit , IGUP I-5111 , interferon gamma up-regulated I-5111 protein , interferon-gamma IEF SSP 5111 , interferon-gamma-inducible protein 5111 , PA28 alpha subunit , proteasome activator 28 alpha subunit , proteasome activator PA28 alpha subunit

30648 Danio rerio
100343673 Oryctolagus cuniculus
29630 Rattus norvegicus
5720 Homo sapiens
480256 Canis lupus familiaris
19186 Mus musculus
397572 Sus scrofa
510041 Bos taurus
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