Browse our anti-Thymidylate Synthetase (TYMS) Antibodies

Full name:
anti-Thymidylate Synthetase Antibodies (TYMS)
On www.antibodies-online.com are 239 Thymidylate Synthetase (TYMS) Antibodies from 25 different suppliers available. Additionally we are shipping Thymidylate Synthetase Proteins (18) and Thymidylate Synthetase Kits (16) and many more products for this protein. A total of 280 Thymidylate Synthetase products are currently listed.
Synonyms:
ECK2823, FN1, HST422, JW2795, TMS, TS

Most Popular Reactivities for anti-Thymidylate Synthetase (TYMS) Antibodies

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anti-Rat (Rattus) Antibodies:

All available anti-Thymidylate Synthetase Antibodies

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Top referenced anti-Thymidylate Synthetase Antibodies

  1. Human Monoclonal TYMS Primary Antibody for IF, WB - ABIN393644 : Kristensen, Pedersen, Melsen, Ellehauge, Mejer: Variants in the dihydropyrimidine dehydrogenase, methylenetetrahydrofolate reductase and thymidylate synthase genes predict early toxicity of 5-fluorouracil in colorectal cancer patients. in The Journal of international medical research 2010 (PubMed)
    Show all 5 references for 393644

  2. Human Monoclonal TYMS Primary Antibody for EIA, IF - ABIN452662 : Shahrokni, Rajebi, Saif: Toxicity and efficacy of 5-fluorouracil and capecitabine in a patient with TYMS gene polymorphism: A challenge or a dilemma? in Clinical colorectal cancer 2009 (PubMed)
    Show all 3 references for 452662

  3. Human Polyclonal TYMS Primary Antibody for FM, IP - ABIN107487 : Sohn, Croxford, Yates, Lucock, Kim: Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate. in Journal of the National Cancer Institute 2004 (PubMed)
    Show all 2 references for 107487

  4. Cow (Bovine) Polyclonal TYMS Primary Antibody for WB - ABIN2783412 : Ikeda, Sasazuki, Natsukawa, Shaura, Koizumi, Kasuga, Ohnami, Sakamoto, Yoshida, Iwasaki, Tsugane: Screening of 214 single nucleotide polymorphisms in 44 candidate cancer susceptibility genes: a case-control study on gastric and colorectal cancers in the Japanese population. in The American journal of gastroenterology 2008 (PubMed)

  5. Human Polyclonal TYMS Primary Antibody for FM, IP - ABIN2801851 : Conradi, Bleckmann, Schirmer, Sprenger, Jo, Homayounfar, Wolff, Rothe, Middel, Becker, Ghadimi, Beissbarth, Liersch: Thymidylate Synthase as a Prognostic Biomarker for Locally Advanced Rectal Cancer after multimodal Treatment. in Annals of surgical oncology 2011 (PubMed)

More Antibodies against Thymidylate Synthetase Interaction Partners

Mouse (Murine) Thymidylate Synthetase (TYMS) interaction partners

  1. Possible interaction routes between hydrophobic residues of the mouse thymidylate synthase protein N-terminal segment and the active site are also discussed

  2. SHMT1 (show SHMT1 Antibodies) and TYMS localization to the nucleus is essential to prevent uracil accumulation in DNA

  3. Synergistic activation of the TATA-less thymidylate synthase promoter by the Ets transcription factor (show ELF2 Antibodies) GABP and Sp1 (show SP1 Antibodies).

  4. downregulation of expression results in block of cell cycle expression when influenced by Fe65 (show APBB1 Antibodies)

  5. posttranslationally-modified thymidylate synthase is associated with cell resistance to 5-fluoro-dUrd

Human Thymidylate Synthetase (TYMS) interaction partners

  1. A PCR technique was used for genotyping TYMS-TSER.

  2. Data suggest that TYMS exhibits a ligand-binding site in dimer interface, suggesting that cavity in dimer interface serves as an allosteric site to regulate conformational switching between active and inactive states of the enzyme.

  3. Combined expression analyses of hENT1, TS, and DPD (show DPYD Antibodies) may predict long-term outcomes in patients with borderline resectable pancreatic cancer after neoadjuvant chemoradiotherapy

  4. In pancreatic neuroendocrine neoplasms, biochemical response (p = 0.005) and high dihydropyrimidine-dehydrogenase (show DPYD Antibodies) expression (p = 0.018) were predictive markers of response to 5-FU-based chemotherapy. Thymidylate-Synthase deficiency was an independent risk factor for shorter progression-free survival.

  5. Data suggest the potential association of methylenetetrahydrofolate reductase (MTHFR (show MTHFR Antibodies)), thymidylate synthase (TS) and TS enhancer region (TSER) polymorphisms with recurrent implantation failure (RIF) risk in Korean patients.

  6. PCB (show PC Antibodies) followed by PB was effective and safe in our study group. This regimen was associated with acceptable toxicity and with prolonged OS. In our cohort both Ki67 (show MKI67 Antibodies) and TS expression were important prognostic biomarkers.

  7. this meta-analysis suggested that thymidylate synthase enhancer region (TSER) variation in the TYMS gene was not related to susceptibility to develop pediatric acute lymphoblastic leukemia

  8. These findings suggested that the down-regulation of AKT (show AKT1 Antibodies)-mediated TS expression by salinomycin enhanced the cisplatin-induced cytotoxicity in nonsmall cell lung cancer cells.

  9. results indicate significant correlation between the Lauren and Goseki histopathological classifications of gastric cancer and TS expression in tumor cells, and suggest that high TS expression may be a positive prognostic marker with regard to DFS (show FST Antibodies) in patients with gastric cancer without involvement of regional lymph nodes who underwent radical surgical treatment and were not treated with preoperative chemotherapy.

  10. High titers of both TYMS and PDLIM1 (show PDLIM1 Antibodies) serum autoantibodies were significantly more prevalent in breast cancer cases than in controls.

Thymidylate Synthetase (TYMS) Antigen Profile

Antigen Summary

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.

Alternative names and synonyms associated with Thymidylate Synthetase (TYMS)

  • thymidylate synthetase (TYMS) antibody
  • thymidylate synthetase (thyA) antibody
  • thymidylate synthetase (td) antibody
  • thymidylate synthetase (thyE) antibody
  • thymidylate synthetase (LOC100037674) antibody
  • thymidylate synthetase (tyms) antibody
  • thymidylate synthetase (LOC100222097) antibody
  • thymidylate synthase (Tyms) antibody
  • thymidylate synthetase (Tyms) antibody
  • ECK2823 antibody
  • FN1 antibody
  • HST422 antibody
  • JW2795 antibody
  • TMS antibody
  • TS antibody

Protein level used designations for TYMS

fibronectin 1 , thymidylate synthase , thymidylate synthetase , thymidylate synthase-like , Tsase , TSase , TS

GENE ID SPECIES
740018 Pan troglodytes
949035 Escherichia coli str. K-12 substr. MG1655
4156567 Aeromonas phage 25
4405636 Enterobacteria phage RB32
7803492 Enterobacteria phage RB51
9415915 Ralstonia solanacearum CFBP2957
9431860 Xenorhabdus nematophila ATCC 19061
9487079 Staphylococcus aureus
9732454 Dickeya dadantii 3937
100037674 Ovis aries
100125228 Xenopus laevis
100222097 Taeniopygia guttata
100459110 Pongo abelii
697580 Macaca mulatta
7803982 Enterobacteria phage RB14
7992740 Methylobacterium extorquens AM1
8195292 Methylobacterium extorquens DM4
8833316 Xenorhabdus bovienii SS-2004
8913233 Erwinia amylovora CFBP1430
9404045 Herbaspirillum seropedicae SmR1
9408872 Ralstonia solanacearum PSI07
22171 Mus musculus
7298 Homo sapiens
29261 Rattus norvegicus
507631 Bos taurus
100627209 Sus scrofa
421060 Gallus gallus
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