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Browse our anti-Thymidylate Synthetase (TYMS) Antibodies

Full name:
anti-Thymidylate Synthetase Antibodies (TYMS)
On www.antibodies-online.com are 227 Thymidylate Synthetase (TYMS) Antibodies from 23 different suppliers available. Additionally we are shipping Thymidylate Synthetase Proteins (19) and Thymidylate Synthetase Kits (16) and many more products for this protein. A total of 269 Thymidylate Synthetase products are currently listed.
Synonyms:
ECK2823, FN1, HST422, JW2795, TMS, TS

Most Popular Reactivities for anti-Thymidylate Synthetase (TYMS) Antibodies

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Top referenced anti-Thymidylate Synthetase Antibodies

  1. Human Monoclonal TYMS Primary Antibody for IF, WB - ABIN393644 : Kristensen, Pedersen, Melsen, Ellehauge, Mejer: Variants in the dihydropyrimidine dehydrogenase, methylenetetrahydrofolate reductase and thymidylate synthase genes predict early toxicity of 5-fluorouracil in colorectal cancer patients. in The Journal of international medical research 2010 (PubMed)
    Show all 5 references for ABIN393644

  2. Human Monoclonal TYMS Primary Antibody for EIA, IF - ABIN452662 : Shahrokni, Rajebi, Saif: Toxicity and efficacy of 5-fluorouracil and capecitabine in a patient with TYMS gene polymorphism: A challenge or a dilemma? in Clinical colorectal cancer 2009 (PubMed)
    Show all 3 references for ABIN452662

  3. Human Polyclonal TYMS Primary Antibody for FM, IP - ABIN107487 : Sohn, Croxford, Yates, Lucock, Kim: Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate. in Journal of the National Cancer Institute 2004 (PubMed)
    Show all 2 references for ABIN107487

  4. Human Polyclonal TYMS Primary Antibody for EIA, IHC (fro) - ABIN116876 : Haqqani, Cowling, Maroun, Birnboim: Characterization of a polyclonal antibody to human thymidylate synthase suitable for the study of colorectal cancer specimens. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999 (PubMed)

  5. Human Polyclonal TYMS Primary Antibody for FM, IP - ABIN2801851 : Conradi, Bleckmann, Schirmer, Sprenger, Jo, Homayounfar, Wolff, Rothe, Middel, Becker, Ghadimi, Beissbarth, Liersch: Thymidylate Synthase as a Prognostic Biomarker for Locally Advanced Rectal Cancer after multimodal Treatment. in Annals of surgical oncology 2011 (PubMed)

  6. Cow (Bovine) Polyclonal TYMS Primary Antibody for WB - ABIN2783412 : Ikeda, Sasazuki, Natsukawa, Shaura, Koizumi, Kasuga, Ohnami, Sakamoto, Yoshida, Iwasaki, Tsugane: Screening of 214 single nucleotide polymorphisms in 44 candidate cancer susceptibility genes: a case-control study on gastric and colorectal cancers in the Japanese population. in The American journal of gastroenterology 2008 (PubMed)

More Antibodies against Thymidylate Synthetase Interaction Partners

Mouse (Murine) Thymidylate Synthetase (TYMS) interaction partners

  1. Possible interaction routes between hydrophobic residues of the mouse thymidylate synthase protein N-terminal segment and the active site are also discussed

  2. SHMT1 (show SHMT1 Antibodies) and TYMS localization to the nucleus is essential to prevent uracil accumulation in DNA

  3. Synergistic activation of the TATA-less thymidylate synthase promoter by the Ets transcription factor (show ELF2 Antibodies) GABP and Sp1 (show SP1 Antibodies).

  4. downregulation of expression results in block of cell cycle expression when influenced by Fe65 (show APBB1 Antibodies)

  5. posttranslationally-modified thymidylate synthase is associated with cell resistance to 5-fluoro-dUrd

Human Thymidylate Synthetase (TYMS) interaction partners

  1. results indicate significant correlation between the Lauren and Goseki histopathological classifications of gastric cancer and TS expression in tumor cells, and suggest that high TS expression may be a positive prognostic marker with regard to DFS (show FST Antibodies) in patients with gastric cancer without involvement of regional lymph nodes who underwent radical surgical treatment and were not treated with preoperative chemotherapy.

  2. High titers of both TYMS and PDLIM1 (show PDLIM1 Antibodies) serum autoantibodies were significantly more prevalent in breast cancer cases than in controls.

  3. Studies suggest that dietary folate intake and gender may modify the associations between 5,10-methylenetetrahydrofolate reductase (MTHFR (show MTHFR Antibodies)) and thymidylate synthase (TS) polymorphisms and adult leukemia risk.

  4. The expressions of TYMS, TUBB3 (show TUBB3 Antibodies) and STMN1 (show STMN1 Antibodies) were significantly associated with the clinicopathological characteristics of age, gender and family history of gastric cancer, but not with differentiation, growth patterns, metastasis and TNM (show ODZ1 Antibodies) staging in patients with gastric cancer.

  5. High expression of TYMS is associated with Colorectal cancer.

  6. This study identified a novel single repeat in the TYMS gene which might have an impact on the expression of this gene, which needs to be confirmed by functional studies.

  7. There were no other associations between single -nucleotide polymorphisms and the efficacy of MTX (show MTX1 Antibodies) treatment. CONCLUSIONS: The MTHFR (show MTHFR Antibodies) 677CC and GGH (show GGH Antibodies) 401TT and CT genotypes were associated with a reduction in the number of MTX (show MTX1 Antibodies)-related adverse events.

  8. Our findings emphasize the pivotal relevance of RNAi as an effective tool for increasing the therapeutic efficacy of PMX (show PRRX1 Antibodies), a cornerstone in the treatment regimens of Malignant mesothelioma thereby, raising the possibility for the development of a novel therapeutic strategy, combination therapy of TS-shRNA and PMX (show PRRX1 Antibodies), that can surpass many of the currently applied, but less effective, therapeutic regimens against lethal MPM.

  9. treatment response, survival, and the associations between KRAS mutation status and tumour expression levels of BRCA1, TYMS and SRC (show SRC Antibodies) retrospectively in a cohort of patients with non-small cell lung cancer, were evaluated.

  10. TYMS gene amplification predicts outcome of patients receiving pemetrexed with advanced non-small cell lung cancer.

Thymidylate Synthetase (TYMS) Antigen Profile

Antigen Summary

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.

Alternative names and synonyms associated with Thymidylate Synthetase (TYMS)

  • thymidylate synthetase (TYMS) antibody
  • thymidylate synthetase (thyA) antibody
  • thymidylate synthetase (td) antibody
  • thymidylate synthetase (thyE) antibody
  • thymidylate synthetase (LOC100037674) antibody
  • thymidylate synthetase (tyms) antibody
  • thymidylate synthetase (LOC100222097) antibody
  • thymidylate synthase (Tyms) antibody
  • thymidylate synthetase (Tyms) antibody
  • ECK2823 antibody
  • FN1 antibody
  • HST422 antibody
  • JW2795 antibody
  • TMS antibody
  • TS antibody

Protein level used designations for TYMS

fibronectin 1 , thymidylate synthase , thymidylate synthetase , thymidylate synthase-like , Tsase , TSase , TS

GENE ID SPECIES
740018 Pan troglodytes
949035 Escherichia coli str. K-12 substr. MG1655
4156567 Aeromonas phage 25
4405636 Enterobacteria phage RB32
7803492 Enterobacteria phage RB51
9415915 Ralstonia solanacearum CFBP2957
9431860 Xenorhabdus nematophila ATCC 19061
9487079 Staphylococcus aureus
9732454 Dickeya dadantii 3937
100037674 Ovis aries
100125228 Xenopus laevis
100222097 Taeniopygia guttata
100459110 Pongo abelii
697580 Macaca mulatta
7803982 Enterobacteria phage RB14
7992740 Methylobacterium extorquens AM1
8195292 Methylobacterium extorquens DM4
8833316 Xenorhabdus bovienii SS-2004
8913233 Erwinia amylovora CFBP1430
9404045 Herbaspirillum seropedicae SmR1
9408872 Ralstonia solanacearum PSI07
22171 Mus musculus
7298 Homo sapiens
29261 Rattus norvegicus
507631 Bos taurus
100627209 Sus scrofa
421060 Gallus gallus
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