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Data show that knockdown of thymidylate synthase (TS) significantly impairs TH17 and TH1 (show HAND1 ELISA Kits) cell differentiation.
Possible interaction routes between hydrophobic residues of the mouse thymidylate synthase protein N-terminal segment and the active site are also discussed
SHMT1 (show SHMT1 ELISA Kits) and TYMS localization to the nucleus is essential to prevent uracil accumulation in DNA
Synergistic activation of the TATA-less thymidylate synthase promoter by the Ets transcription factor GABP and Sp1 (show SP1 ELISA Kits).
downregulation of expression results in block of cell cycle expression when influenced by Fe65 (show APBB1 ELISA Kits)
posttranslationally-modified thymidylate synthase is associated with cell resistance to 5-fluoro-dUrd
Study shows that the TYMS TSER 3R allele increases the risk of thymic lymphoid hyperplasia in AChR+ Myasthenia Gravis (MG) patients and that the 3R allele in the promoter enhancer region results in increased protein production required for the synthesis of DNA precursors.
polymorphisms of TS 5'-UTR (show UTS2R ELISA Kits) 2R (double repeats)/3R (triple repeats) of a 28-bp sequence (11 articles) and 3'-UTR (show UTS2R ELISA Kits) del6/ins6 (seven articles) were not significantly associated with increased risk of gastric cancer.
There was significantly higher thymidylate synthase (TS) expression in non-small cell lung cancer (NSCLC) tumor tissue comparing to normal lung tissue.
Crystal structure of the active form of native human thymidylate synthase in the absence of bound substrates has been reported.
The Thymidylate synthase (TS)-ZEB1 (show ZEB1 ELISA Kits) association was confirmed in clinical specimens from lung tumours and in a genetic mouse model of pancreatic cancer with ZEB1 (show ZEB1 ELISA Kits) deletion. Interestingly, TS itself appeared to have a regulatory role in epithelial-to-mesenchymal in cancer cells, as TS knockdown could directly reduce the EMT (show ITK ELISA Kits) phenotype, the migratory ability of cells, the expression of stem-like markers, and chemoresistance.
Study of genetic risk of prevalent hrHPV infections in Nigerian women found significant associations with SNPs on ribosomal protein gene S19 (RPS19 (show RPS19 ELISA Kits)) and Thymidylate Synthase gene (TYMS), in an allelic model. This risk remained significant, after adjusting for age, body mass index, smoking, age at menarche, age at sexual debut, lifetime total number of sexual partners and the total number of pregnancies.
High thymidylate synthetase expression is associated with chemoresistance in glioblastoma multiforme.
A PCR technique was used for genotyping TYMS-TSER.
Data suggest that TYMS exhibits a ligand-binding site in dimer interface, suggesting that cavity in dimer interface serves as an allosteric site to regulate conformational switching between active and inactive states of the enzyme.
Combined expression analyses of hENT1, TS, and DPD (show DPYD ELISA Kits) may predict long-term outcomes in patients with borderline resectable pancreatic cancer after neoadjuvant chemoradiotherapy
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.
, thymidylate synthase
, thymidylate synthetase
, thymidylate synthase-like