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These results suggest that CROT activity, by controlling the peroxisomal amount of medium chain acyls, may control the peroxisomal oxidative pathway.
Selected 'Tpl2/Cot (show MAP3K8 ELISA Kits)-YL ribozyme' efficiently cleaves its target sequence in cis (show CISH ELISA Kits) and in trans; furthermore, the ribozyme efficiently cleaves a longer target sequence of 54 nucleotides in trans, as well as the full-length mRNA.
CROT encodes carnitine octanoyltransferase, an enzyme known from rat studies to act on products of peroxisomal fatty acid oxidation. Medium-chain acylcarnitines are thought to be transported from peroxisomes to mitochondria.
the crystal structures of carnitine octanoyltransferase alone and in complex with the substrate octanoylcarnitine
This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.
, peroxisomal carnitine O-octanoyltransferase-like
, peroxisomal carnitine O-octanoyltransferase
, peroxisomal carnitine acyltransferase