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PEX2 (show PEX2 Proteins) and PEX10 cooperate to support import of matrix proteins into plant peroxisomes and peroxin5 retrotranslocation in Arabidopsis.
Data show that formation of glyoxysomal reticulum seemed to be impaired in PEX10-DeltaZn but not in PEX2 (show PEX2 Proteins)-DeltaZn-T7 or PEX12 (show PEX12 Proteins)-DeltaZn-T7 plants.
PEX2 (show PEX2 Proteins) and PEX10 are inserted into peroxisome membranes directly from the cytosol.
AtPEX19-1 was shown to bind to the Arabidopsis peroxisomal membrane protein PEX10.
inactivation of the RING finger (show PCGF1 Proteins) domain in PEX10 has eliminated protein interaction required for attachment of peroxisomes to chloroplasts and movement of metabolites between peroxisomes and chloroplasts
This study demonstrated that two mutations in PEX10 were found in the three peroxisomal biogenesis disorders patients: c.827G>T (novel) causing the missense change p.Cys276Phe and c.932G>A causing the missense change p.Arg311Gln.
abnormal expression of PEX10 gene resulting from copy number variations of 1p36 region may be associated with the epilepsy phenotype
child and an adult of normal intelligence with progressive ataxia, axonal motor neuropathy, decreased vibration sense and cerebellar atrophy; 2 mutations in PEX10 found in child, c.992G>A and c.764_765insA, and in the adult, c.2T>C and c.790C>T
Genetic heterogeneity in Japanese patients with peroxisome biogenesis disorders and evidence for a founder haplotype for the most common mutation in PEX10 gene.
the relative fraction of disease-causing alleles that occur in the coding and splice junction sequences of PEX10 gene.
This gene encodes a protein involved in import of peroxisomal matrix proteins. This protein localizes to the peroxisomal membrane. Mutations in this gene result in phenotypes within the Zellweger spectrum of peroxisomal biogenesis disorders, ranging from neonatal adrenoleukodystrophy to Zellweger syndrome. Alternative splicing results in two transcript variants encoding different isoforms.
RING finger protein 69
, peroxin 10
, peroxisome assembly protein 10
, peroxisome biogenesis factor 10
, peroxisomal biogenesis factor 10