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The data provide the first functional assessment of the role of caldesmon in cardiac development in vivo, and indicate that caldesmon is essential for proper cardiac organogenesis and function.
rs 3807337 polymorphism of CALD1 gene is associated with diabetic nephropathy occurrence in type 1 diabetes.
ANXA1 (show ANXA1 Proteins) and CALD1 proteins are independent markers for tamoxifen therapy outcome and are associated to fast tumor progression.
Data indicate that low-molecular-weight caldesmon isoforms (L-CAD) promotes migration and invasiveness of urothelial bladder carcinoma (BC) cells.
Caldesmon and smoothelin (show SMTN Proteins) staining allows better delineation of the muscularis propria from the desmoplastic stromal reaction which provides a critical aide for proper staging of colonic adenocarcinomas.
caldesmon is not useful in distinguishing between peritoneal epithelioid mesotheliomas and papillary serous carcinomas involving the peritoneum
The data suggest that PKGIbeta enhances breast cancer cell motility and invasive capacity, at least in part, by phosphorylating CaD.
Caldesmon is a possible predictor of endometrial dysregulation in patients with endometriosis.
Caldesmon expression inhibits cancer cell migration and invasiveness.
Disruption of the normal inhibitory function of human caldesmon 1 enhances intestinal peristalsis in both wild-type zebrafish larvae and mutant larvae that lack enteric nerves
Data found phasic phosphorylation of caldesmon and ERK 1 (show MAPK3 Proteins)/2 during contractions in human myometrium.
Use short interfering RNA technology to decrease the levels of the smooth muscle-specific (show EIF3K Proteins) isoform of caldesmon in intact vascular smooth muscle tissue to determine what role(s) caldesmon has in smooth muscle regulation.
Acrylodan-labeled tropomyosin fluorescence responses to rapid myosin subfragment S1-ATP detachment in the presence of caldesmon are similar to those observed in the presence of troponin.
Effect of long-term partial bladder outlet obstruction on caldesmon isoforms and their correlation with contractile function are reported.
Silencing of Sox4 decreased not only CaD protein synthesis but also myoblast fusion in C2C12 cells and myofibril formation in mouse embryonic muscle. Overexpression of CaD in Sox4-silenced C2C12 cells rescued the differentiation process.
Caldesmon-deficient mouse arterial muscles relax more slowly than wild-type tissues.
distribution of the actin-binding protein (show PFN1 Proteins) caldesmon in spleen and lymph nodes of mice and rats
Caldesmon binds and stabilizes actin filaments, as well as regulates actin-myosin interaction in a calcium (Ca2 (show CA2 Proteins)+)/calmodulin (CaM)- and/or phosphorylation-dependent manner. (Review)
K-cyclin (show PCNA Proteins) expression modulates the activity of caldesmon and through this the microfilament functions in cells
This study reports a novel molecular mechanism (caldesmon), as well as a structural basis (podosomes/rosettes), to show how p53 (show TP53 Proteins) can act as an anti-motility/invasion/metastasis agent.
This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
, accessory protein BAP31
, smooth muscle caldesmon
, caldesmon, smooth muscle
, non-muscle caldesmon