Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species
GRK2 (show ADRBK1 ELISA Kits) and GRK5 control cardiac function as well as morphogenesis during development although with different morphological outcomes.
Results identify GRK5/6 as novel kinases for the single transmembrane receptor LRP6 (show LRP5 ELISA Kits) during Wnt (show WNT2 ELISA Kits) signaling.
Candidate gene eQTL (show EQTN ELISA Kits) showed a trans-acting association between variants of G protein-coupled receptor kinase 5 gene (show GPD1 ELISA Kits), previously linked to altered BB response, and high expression of VOPP1 (show VOPP1 ELISA Kits).
Further, we will also present potential therapeutic strategies (i.e. small molecule inhibition, gene therapy) that may have potential in combating the deleterious effects of GRK5 in heart failure.
Suggest a common regulatory pattern for the beta(1)-AR/GRK5 which is independent of cellular type or pathology.
We demonstrated that the SNPs and the related haplotypes of GRK5 could play a central role in predisposing Parkinson disease patients to cognitive impairment.
Thus, we provided new insight into the function of GRKs in agonist-unstimulated GPCR (show NMUR1 ELISA Kits) trafficking using a recombinant AM1 receptor and further determined the region of the CLR C (show CLEC2G ELISA Kits)-tail responsible for this GRK (show GRK4 ELISA Kits) function.
ADORA2A (show ADORA2A ELISA Kits) and GRK5 gene variants may influence the etiology of malaria infection.
A significant difference in the frequency of GRK5 polymorphism was found between Takotsubo cardiomyopathy patients and controls, supporting a genetic predisposition to this cardiac syndrome.
Specific patterns of altered heart GRK5 gene expression were found in models of cardiac hypertrophy.
This study sought to identify the distributed characteristics of these variant genotypes in Chinese population, and influence of GRK5 and ADRB1 (show ADRB1 ELISA Kits) polymorphisms on systolic heart failure morbidity.
GRK5 is found in a partially closed state with its kinase domain C-tail forming novel interactions with nucleotide and the N-lobe (show LTF ELISA Kits).
Generated mice with genetic knockout (KO) of the G protein-coupled receptor kinase (GRK) 5 gene (show GPD1 ELISA Kits) by microinjection of TALEN mRNA. TALEN vectors were designed to target exons 1, 3, and 5 of the mouse GRK5 gene.
These results of this study suggest that GRK5 deficiency indeed makes the mice more susceptible to wide range of behavioral impairments, including cognitive impairments.
MOR (show OPRM1 ELISA Kits) phosphorylation is regulated by agonist-selective recruitment of distinct GRK (show GRK4 ELISA Kits) isoforms that influence different opioid-related behaviors. Modulation of GRK5 function could serve as a new approach for preventing addiction to opioids.
GRK5, acting in a kinase independent manner, is a facilitator of NFAT (show NFATC1 ELISA Kits) activity and part of a DNA-binding complex responsible for pathological hypertrophic gene transcription.
influence of GRK5 on NF-kappaB (show NFKB1 ELISA Kits) expression and activity
these data identified GRK5 as a positive regulator of insulin (show INS ELISA Kits) sensitivity.
metoprolol is a biased ligand that selectively activates a G protein-independent and GRK5/beta-arrestin2 (show ARRB2 ELISA Kits)-dependent pathway, and induces cardiac fibrosis.
These results define myocyte GRK5 as a critical regulator of pathological cardiac growth after ventricular pressure overload, supporting its role as an endogenous (patho)-physiological HDAC (show HDAC3 ELISA Kits) kinase.
these results suggest that GRK5 is an important regulator of adipogenesis and is crucial for the development of diet-induced obesity.
GRK5 regulates IL-12p40 and G-CSF (show CSF3 ELISA Kits) via a mechanism that is common to both MyD88 (show MYD88 ELISA Kits) and TRIF (show RNF138 ELISA Kits).
potential GRK5 interacting proteins and the association of GRK5 with DDB1 in cell and the regulation of GRK5 level by DDB1-CUL4 ubiquitin ligase complex-dependent proteolysis pathway
GRK5 overexpression causes nuclear accumulation of IkappaB alpha, leading to the inhibition of NFkappaB transcriptional activity.
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs).
G protein-coupled receptor kinase 5
, g protein-coupled receptor kinase GRK5