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Rat (Rattus) GRK6 ELISA Kit for Sandwich ELISA - ABIN815625
Oda, Tadokoro, Takase, Kanahara, Watanabe, Shirayama, Hashimoto, Iyo: G protein-coupled receptor kinase 6/?-arrestin 2 system in a rat model of dopamine supersensitivity psychosis. in Journal of psychopharmacology (Oxford, England) 2015
Decreased expression of GRK6 may serve as an independent predictor of overall survival in lung adenocarcinoma.
The expression of GRK6 mRNA and protein was significantly lower in hypopharyngeal squamous cell carcinoma than in corresponding adjacent non-tumor tissues. This was associated with aberrant methylation of the gene.
Our results imply that GRK6 may not play a role in the pathophysiology of schizophrenia among Han Chinese
these results indicate that GRK6 complexes with AGS3 (show GPSM1 ELISA Kits)-Galphai2 (show GNAI2 ELISA Kits) to regulate CXCR2 (show CXCR2 ELISA Kits)-mediated leukocyte functions at different levels, including downstream effector activation, receptor trafficking, and expression at the cell membrane.
GRK6 plays a predominant role in phosphorylation of FFA receptor (FFA)4.
results suggested that GRK6 overexpression plays an important role in hepatocellular carcinoma
Downregulation of GRK6 expression enhances CXCR4 (show CXCR4 ELISA Kits) signaling and promoted medulloblastoma cell migration.
A reduced cortical concentration of GRK6 in schizophrenia (resembling that in aging) may result in altered G protein-dependent signaling, thus contributing to prefrontal deficits in schizophrenia.
inhibition of GRK6 represents a uniquely targeted novel therapeutic strategy in human multiple myeloma.
A number of double mutations of GRK6 kinase within helices 3, 9, and 10 reduced phosphorylation of the beta2 adrenergic receptor (show ADRB2 ELISA Kits) and rhodopsin (show RHO ELISA Kits) compared to wild-type GRK6 kinase.
GRK6-mediated OXTR (show OXTR ELISA Kits) desensitization in labor is necessary for normal uterine contractile patterns and optimal fetal outcome.
GRK6 directly phosphorylates Nfkbia (show NFKBIA ELISA Kits) at Ser32/Ser36. Knockdown of GRK6 suppresses TNF-alpha (show TNF ELISA Kits)-induced NF-kappaappaB signaling.
data demonstrate that GRK6 plays a feedback regulatory role in CXCR2 (show CXCR2 ELISA Kits)-mediated tumor development, invasion and metastasis
G-protein-coupled receptor kinase 6 (GRK6) is involved in apoptotic cell clearance.
Chemokine receptor CXCR2 (show CXCR2 ELISA Kits) interacts with GRK6 to negatively regulate receptor sensitization and trafficking, thus affecting cell signaling and angiogenesis.
Results identify GRK5 (show GRK5 ELISA Kits)/6 as novel kinases for the single transmembrane receptor LRP6 (show LRP6 ELISA Kits) during Wnt (show WNT2 ELISA Kits) signaling.
Postsynaptic D2-like dopamine receptors are physiological targets for GRK6 and suggests that this regulatory mechanism contributes to central dopaminergic supersensitivity.
In the absence of GRK6, the G-CSF (show CSF3 ELISA Kits)-induced increase in circulating neutrophils is profoundly impaired. After injection of pegylated-G-CSF (show CSF3 ELISA Kits), significantly lower numbers of circulating neutrophils were observed in GRK6-/- as compared with wild-type (WT) mice.
The results suggest that mouse G-protein-coupled receptor (show GPR34 ELISA Kits) kinase isoform 6-C may be considered a basic, prototypic representative of the GRK4 (show GRK4 ELISA Kits)-like kinases.
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene.
G protein-coupled receptor kinase 6
, G protein-coupled receptor kinase 6-like
, g protein-coupled receptor kinase GRK6
, G-protein coupled receptor kinase 6