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Chinese family with dual LQT1 (show KCNQ1 Proteins) and HCM phenotypes associated with tetrad heterozygous mutations in KCNQ1 (show KCNQ1 Proteins), MYH7 (show MYH7 Proteins), MYLK2, and TMEM70 (show TMM70 Proteins) mutations.
This study demonstrates that cyclic stretch disrupts tight junctions and adherens junctions by a JNK2 (show MAPK9 Proteins), c-Src (show SRC Proteins), and MLCK (show MYLK Proteins)-dependent mechanism.
Biochemical and physiological regulation of cardiac myocyte contraction by cardiac-specific myosin light chain kinase (show MYLK3 Proteins).
These findings suggest that hepatitis B virus X protein disrupts stress fiber formation and triggers apoptosis via an MLCK and a PTEN-dependent pathway.
the P2X1 (show P2RX1 Proteins)-ERK2 (show MAPK1 Proteins)-Myosin Light Chain Kinase (show MYLK Proteins) axis contributes to collagen-induced platelet activation by enhancing platelet degranulation
These data suggest that the kinase domain of MYLK2 is rarely mutated in common human carcinomas and that it does not play a dominant role in cancer pathogenesis.
MYLK (show MYLK Proteins) gene is a risk factor for the development of acute lung injuries.
Data show that that the prototypical CaM (show CALM1 Proteins) target sequence skMLCK, a fragment from skeletal muscle myosin light chain kinase (show MYLK Proteins), binds to CaM (show CALM1 Proteins) in a highly cooperative way, while only a lower degree of interdomain binding cooperativity emerges for CaMKK (show CAMKK2 Proteins).
Integrated cDNA expression analysis of failing human myocardia uncovered a novel protein kinase (show CDK7 Proteins), cardiac-specific myosin light chain kinase (cardiac-MLCK (show MYLK3 Proteins)), which acts on MLC2v (show MYL2 Proteins).
data indicate that the IL-1beta (show IL1B Proteins)-induced increase in MLCK (show MYLK Proteins) protein expression and Caco-2 TJ permeability was mediated by an increase in MLCK (show MYLK Proteins) expression and activity and by an NF-kappaB (show NFKB1 Proteins)-dependent increase in MLCK (show MYLK Proteins) gene transcription
This gene encodes a myosin light chain kinase, a calcium/calmodulin dependent enzyme, that is exclusively expressed in adult skeletal muscle.
myosin light chain kinase 2, skeletal muscle
, myosin light chain kinase 2, skeletal/cardiac muscle
, myosin light chain kinase 2-like
, skeletal myosin light chain kinase
, myosin, light polypeptide kinase 2