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Human Polyclonal PRKD1 Primary Antibody for IHC (p), WB - ABIN391011
Wu, Solaro: Protein kinase C zeta. A novel regulator of both phosphorylation and de-phosphorylation of cardiac sarcomeric proteins. in The Journal of biological chemistry 2007
Show all 3 Pubmed References
Human Polyclonal PRKD1 Primary Antibody for ELISA, WB - ABIN562395
Sin, Martin, Wills, Currie, Baillie: Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy. in Cell communication and signaling : CCS 2015
Show all 2 Pubmed References
Human Polyclonal PRKD1 Primary Antibody for ICC, IF - ABIN4345848
Weinreb, Piscuoglio, Martelotto, Waggott, Ng, Perez-Ordonez, Harding, Alfaro, Chu, Viale, Fusco, da Cruz Paula, Marchio, Sakr, Lim, Thompson, Chiosea, Seethala, Skalova, Stelow, Fonseca, Assaad, How et al.: Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands. ... in Nature genetics 2014
cloning and expression analysis of a protein kinase C (show PKC Antibodies) gene, PKCmu, and its regulation of the promoter region (PKCmu)
PKD1 (show PKD1 Antibodies) contributes to the regulation of physiological angiogenesis and lymphangiogenesis during zebrafish development and is essential for tumor angiogenesis.
A single nucleotide polymorphism located within the fourth intron of PRKD1 (rs57803087) was strongly associated with DPP-4 (show DPP4 Antibodies) inhibitor response in patients with type 2 diabetes
Mutation in PRKD1 gene is associated with congenital heart defects.
Bradykinin stimulates myofibroblast migration through protein kinase D-mediated activation of COX-2 (show COX2 Antibodies) and Hsp27 (show HSPB1 Antibodies).
Lysophosphatidic acid/PKD-1 (show PKD1 Antibodies) signaling leads to nuclear accumulation of histone deacetylase 7 (show HDAC7 Antibodies), where it interacts with forkhead box protein O1 (show FOXO1 Antibodies) to suppress endothelial CD36 (show CD36 Antibodies) transcription and mediates silencing of antiangiogenic switch, resulting in proangiogenic and proarteriogenic reprogramming.
This study discovered and characterized a novel, highly conserved N-terminal domain, comprising 92 amino acids, which mediates dimerization of Protein Kinase D (PKD) isoforms, PKD1 (show PKD1 Antibodies), PKD2 (show PKD2 Antibodies), and PKD3 (show PRKD3 Antibodies) monomers.
MC stimulation by physical contact with T cells results in PKD activation, leading to the phosphorylation of p38 (show CRK Antibodies), degranulation and release of cytokines. Understanding the molecular events associated with T cell-induced MC activation might lead to therapeutic approaches for controlling T cell-mediated inflammatory processes in which MC participate.
Data suggest the role of the phospholipase C epsilon (show PLCL1 Antibodies)-Protein kinase D-PEA15 (show PEA15 Antibodies) protein-ribosomal S6 kinase (show RPS6KB1 Antibodies)-IkappaB-NF-kappa B (show NFKB1 Antibodies) pathway in facilitating inflammation and inflammation-associated carcinogenesis in the colon.
PRKD1 Mutation is not associated with Solid Tumors and Leukemias.
Knockdown of PKD1 (show PKD1 Antibodies) did not affect NMDAR (show GRIN1 Antibodies) internalization but prevented the phosphorylation and inhibition of remaining surface NMDARs and NMDAR (show GRIN1 Antibodies)-mediated synaptic functions.
Studies indicate that the loss of protein kinase D PKD1 is thought to promote invasion and metastasis, while PKD2 (show PKD2 Antibodies) and upregulated PKD3 (show PRKD3 Antibodies) to be positive regulators of proliferation.
These findings imply that PKD1 (show PKD1 Antibodies) plays a critical regulatory role in Group B streptococci (GBS (show GNB5 Antibodies))-induced proinflammatory reactions and sepsis, and inhibition of PKD1 (show PKD1 Antibodies) activation together with antibiotic treatment in GBS (show GNB5 Antibodies)-infected neonates could be an effective way to control GBS (show GNB5 Antibodies) diseases.
Our studies demonstrate that PKD1 (show PKD1 Antibodies)/2 is a key regulator of MVB maturation and exosome secretion, and constitutes a mediator of the DGK alpha (show DGKA Antibodies) effect on MVB secretory traffic.
Our results show that AKAP13 (show AKAP13 Antibodies)-PKD1 (show PKD1 Antibodies) signaling is critical for transcriptional regulation of key contractile, cell death, and metabolic pathways during the development of compensatory hypertrophy in vivo.
PKD1 (show PKD1 Antibodies) acts downstream of TGFalpha and Kras, to mediate formation of ductal structures through activation of the Notch (show NOTCH1 Antibodies) pathway.
Results reveal that whereas protein kinase D1 and protein kinase D2 (show PKD2 Antibodies) are essential for neuronal polarity, there exists a functional redundancy between the two proteins.
PKD controls synaptic plasticity and learning by regulating actin stability in dendritic spines.
regulatory kinase of eNOS (show NOS3 Antibodies) in endothelial cells whose activity orchestrates mammalian vascular tone
Overexpression of constitutively active PKD1 (show PKD1 Antibodies) in rodent heart results in dilated cardiomyopathy.
PKD1 (show PKD1 Antibodies)-deficient keratinocytes showed an increase in transglutaminase expression and activity, indicating an anti-differentiative role of PKD1 (show PKD1 Antibodies). Furthermore, the PKD1 (show PKD1 Antibodies)-deficient keratinocytes exhibited decreased proliferation.
AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
Data indicate that Ser738/742-to-glutamate (show GRIN2A Antibodies) protein kinase D mutant increased AngII-induced CREB (show CREB1 Antibodies) protein and activating transcription factor 2 (show ATF2 Antibodies) phosphorylation, and phospho-CREB (show CREB1 Antibodies) binding to the steroidogenic acute regulatory protein (show STAR Antibodies) promoter.
These results indicate that PKD is downstream of PLD (show PLD Antibodies) and suggest that PKD is one of the mechanisms through which PLD (show PLD Antibodies) promotes aldosterone production in response to AngII in adrenal glomerulosa cells.
PKD mediates acute AngII-induced aldosterone secretion.
Protein kinase D-HDAC5 pathway plays an important role in VEGF regulation of gene transcription and angiogenesis
PRKD1 is a serine/threonine kinase that regulates a variety of cellular functions, including membrane receptor signaling, transport at the Golgi, protection from oxidative stress at the mitochondria, gene transcription, and regulation of cell shape, motility, and adhesion (summary by Eiseler et al., 2009
protein kinase D1
, protein kinase C, mu
, serine/threonine-protein kinase D1-like
, protein kinase C mu type
, protein kinase D
, serine/threonine-protein kinase D1
, protein kinase C mu