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Data support the notion that the Galpha (show SUCLG1 Proteins), but not Gbetagamma, arm of the Gi/o signalling is involved in TRPC4 (show TRPC4 Proteins) activation and unveil new roles for RGS (show PITX2 Proteins) and RGS14 in fine-tuning TRPC4 (show TRPC4 Proteins) activities.
The RBD (show CACNA1D Proteins) region associates with the RGS (show PITX2 Proteins) domain region, producing an intramolecular interaction within RGS14 that enhances the GTPase (show RACGAP1 Proteins) activating function.
RGS14 can form complexes with GPCRs in cells that are dependent on Galpha (show SUCLG1 Proteins)(i/o) and these RGS14.Galpha (show SUCLG1 Proteins)(i1).GPCR (show NMUR1 Proteins) complexes may be substrates for other signaling partners such as Ric-8A (show RIC8A Proteins)
RGS-14 may facilitate cognitive processing by modulating Cav1 (show CAV1 Proteins) channel-mediated intracellular divalent calcium ion Ca(2 (show CA2 Proteins))+ transients.
RGS14 serves as a novel scaffold to integrate GTP-Binding Protein alpha Subunit (show POLG Proteins) and Ras/Raf (show RAF1 Proteins)/MAPkinase signalling events through the action of its GL domain.
We show that RGS14 is a component of mitotic asters formed in vitro from HeLa cell extracts and that depletion of RGS14 from cell extracts blocks aster formation.
NMR 1H, 13C and 15N resonances of the RGS (show PITX2 Proteins) domain (residues 56-207)
Study shows that RGS14 (show RGS16 Proteins) mRNA and protein are upregulated throughout postnatal mouse development, and RGS14 (show RGS16 Proteins) protein exhibits a dynamic localization pattern that is enriched in hippocampus and primary olfactory cortex in the adult mouse brain
Inactive Galpha(i1)-GDP enhances the affinity of RGS14 for H-Ras-GTP in live cells, resulting in a ternary signaling complex that is further regulated by G protein-coupled receptors.
Activation of the Rsg14-Galphai1-GDP signaling complex is regulated by Ric8 (show RIC8A Proteins).
These results demonstrate that RGS14 (show RGS16 Proteins) is a key regulator of signaling pathways linking synaptic plasticity in CA2 (show CA2 Proteins) pyramidal neurons to hippocampal-based learning and memory but distinct from the canonical DG-CA3 (show CA3 Proteins)-CA1 (show CA1 Proteins) circuit.
the RGS14 (show RGS16 Proteins) GoLoco domain discriminates among Galphai isoforms
RGS14 (show RGS16 Proteins) is found ubiquitously throughout the postimplantation period in mice
RGS14 (show RGS16 Proteins) activity towards heterotrimeric G-proteins, as either a GAP or a guanine nucleotide dissociation inhibitor, was unaffected by Rap (show LRPAP1 Proteins) binding.
Morphine activation of Mu opioid receptors RGS14 (show RGS16 Proteins) prevents G-protein-coupled receptor (show GPR34 Proteins) kinases from phosphorylating those residues required for receptor endocytosis.
This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
regulator of G-protein signaling 14
, regulator of G-protein signalling 14
, Regulator of G-protein signaling 14
, regulator of G-protein signaling 14-like
, RAP1/RAP2-interacting protein
, rap1/rap2 interacting protein