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Human RGS2 Protein expressed in Escherichia coli (E. coli) - ABIN667395
Santos de Araujo, Oba, Moriyama: Role of regulator of G-protein signaling 2 (RGS2) in periodontal ligament cells under mechanical stress. in Cell biochemistry and function 2007
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Gonadotropin-dependent up-regulation of RGS2 in equine and bovine preovulatory follicles and regulatory controls involved in RGS2 gene expression in granulosa cells.
Knockdown of endogenous Rgs2 expression led to abnormal embryonic development in vitro, with a considerable number of early embryos arrested at the 2- or 4-cell stage. Moreover, mRNA expression of three zygotic gene activation-related genes (i.e. Zscan4 (show ZSCAN4 Proteins), Tcstv1 and MuERV-L) was decreased significantly in 2-cell arrested embryos. These results suggest that Rgs2 plays a critical role in early embryo development.
RGS2 deficiency decreases uterine artery blood flow by increasing myogenic tone at least partly through prolonged G protein activation
Rgs12 (show RGS12 Proteins) has a crucial role in the function of bone-resorbing OCs, particularly in preclinical models of pathological bone loss associated with inflammation-induced bone loss and postmenopausal osteoporosis.
RGS2 deficiency impairs renal function and autoregulation by increasing renal vascular resistance and reducing renal blood flow.
FBXO44 (show FBXO44 Proteins)-mediated degradation of RGS2 protein uniquely depends on a Cul4B (show CUL4B Proteins)/DDB1 (show DDB1 Proteins) complex.
Regulator of G-protein signaling 2 (RGS2) suppresses premature calcium release in mouse eggs.
genetic variations and increased inflammatory cytokines can lead to RGS2 repression, which exacerbates AHR (show AHR Proteins) and airway remodeling in asthma.
RGS2 and RGS4 are new interacting partners that play key roles in G protein coupling to negatively regulate kappa-OmicronR signaling.
RGS2-deficient VSMC exhibit higher rates of proliferation and coordinate plasticity of Ca(2 (show CA2 Proteins)+)-handling mechanisms in response to PDGF (show PDGFA Proteins) stimulation.
Regulator of G protein signaling 2 deficiency accelerates the progression of kidney fibrosis
The RGS2 (-391, C>G) genetic polymorphism may serve as a biomarker to predict a patient's response to antihypertensive drug therapy
MIR4717 regulates human RGS2 and contributes to the genetic risk towards anxiety-related traits.
RGS2 polymorphisms were found to be associated with anxiety disorders and dimensional as well as intermediate phenotypes of anxiety.
RGS2 localizes to the mitotic spindle in a Nek7 (show NEK7 Proteins)-dependent manner, and along with Nek7 (show NEK7 Proteins) contributes to spindle morphology and mitotic spindle pole integrity.
Data show that regulator of G protein signaling 2 (RGS2) was stabilized by deubiquitinase monocyte chemotactic protein-induced protein 1 (MCPIP1 (show ZC3H12A Proteins)).
Epigenetic repression of RGS2 by UHRF1 (show UHRF1 Proteins) contributes to bladder cancer progression. UHRF1 (show UHRF1 Proteins) inhibits RGS2 expression by increasing the methylation of CpG nucleotides of the RGS2 promoter.
ACE (show ACE Proteins) and RGS2 genotypes are not associated with the development of hypertension in patients with type 1 diabetes mellitus.
This work highlights the role of RGS2 as a key regulator of LRRK2 (show LRRK2 Proteins) activity, function and neuronal toxicity.
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis.
regulator of G-protein signaling 2
, regulator of G-protein signalling 2
, regulator of G-protein signaling protein 2
, regulator of G-protein signalling 2, 24kDa
, G0 to G1 switch regulatory 8, 24kD
, G0/G1 switch regulatory protein 8
, cell growth-inhibiting gene 31 protein
, cell growth-inhibiting protein 31