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Findings suggest that overexpressed RGS3 regulated by microRNA-126 through the post-transcriptional modulation is associated significantly with a poor prognosis of GC patients.
Our data provide a novel miR (show MLXIP Proteins)-25/RGS3 signal in the development of lung cancer.
cardiac overexpression of RGS3 inhibits maladaptive hypertrophy and fibrosis and improves cardiac function by blocking MEK-ERK1/2 signaling
ectopic expression of R4 subfamily members RGS2 (show RGS2 Proteins), RGS3, RGS4 (show RGS4 Proteins), and RGS5 (show RGS5 Proteins) reduced activated PAR1 (show MARK2 Proteins) wild-type signaling, whereas signaling by the PAR1 (show MARK2 Proteins) AKKAA mutant was minimally affected.
PDZ-RGS3 can enhance signals generated by the Wnt (show WNT2 Proteins) canonical pathway and plays a pivotal role in epithelial mesenchymal transition
Results suggest that the 14-3-3 protein (show YWHAE Proteins) binding affects the structure of the Galpha (show SUCLG1 Proteins) interaction portion of RGS3 as well as sterically blocks the interaction between the RGS (show PITX2 Proteins) domain and the Galpha (show SUCLG1 Proteins) subunit of heterotrimeric G proteins.
14-3-3 protein (show YWHAE Proteins) binding induces structural changes in both the N-terminal part and the C-terminal RGS (show PITX2 Proteins) domain of phosphorylated RGS3 molecule
Regulator of G-protein signalling 3 (RGS3) showed a difference between follicular cells from follicles leading to a pregnancy or developmental failure.
Data are consistent with the model wherein 14-3-3 (show YWHAQ Proteins) serves as a scavenger of RGS3, regulating the amounts of RGS3 available for binding G-proteins.
C2PA is expressed in the cell nucleus and induces heat shock response element (HSE (show HSD17B6 Proteins))-dependent gene transcription
RGS3 may provide protection against pathological changes of adventitial fibroblasts and the development of atherosclerosis by inhibiting TGF-beta1 (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) signaling.
Results reveal an essential role of PDZ-RGS3 in maintaining the balance between self-renewal and differentiation of neural progenitor cells and provide genetic evidence linking PDZ-RGS3 to ephrin-B reverse signaling.
This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear.
regulator of G-protein signalling 3
, regulator of G-protein signaling 3
, regulator of G-protein signaling 3-like
, regulator of G protein signaling 3
, C2 membrane binding, PDZ protein/protein interaction, ATP/GTP binding domains