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study shows that HA117 potentially promotes the stem-like signature of the HL60/ATRA cell line by inhibiting by the ubiquitination and degradation of DNMT1 (show DNMT1 Proteins) and by down-regulating the expression of the GGL (show GGT5 Proteins) domain of RGS6
genetic association studies on a population in Republic of Korea: Data suggest that an SNP in RGS6 (rs2239219) is closely linked to stress-induced abdominal obesity in the population studied.
Data support the notion that the Galpha (show SUCLG1 Proteins), but not Gbetagamma, arm of the Gi/o signalling is involved in TRPC4 (show TRPC4 Proteins) activation and unveil new roles for RGS (show PITX2 Proteins) and RGS6 in fine-tuning TRPC4 (show TRPC4 Proteins) activities.
No significant association between SNPs of RGS6 and central adiposity has been found.
reduced RGS6 expression is associated with poor survival in colorectal cancer patients, suggesting that RGS6 expression may serve as an important prognostic marker
these date demonstrate that RGS6 decreases in tumor tissue and may serve as a novel biomarker for outcomes in pancreatic cancer patients and be a potential therapeutic target potential therapeutic target.
we found a novel mutation in RGS6, the splice-acceptor variant c.1369-1G>C that was not previously reported in congenital cataract phenotypes.
genetic association studies in Hispanic-American families in Texas and Colorado: SNP in RGS6 are associated with high dietary fat intake, food preferences, and adiposity/obesity phenotype
RGS6-induced apoptosis in both breast cancer cells and mouse embryonic fibroblasts does not require its GAP activity toward G proteins
interacts with SCG10 (show STMN2 Proteins) and promotes neuronal differentiation; role of the G gamma subunit-like (GGL (show GGT5 Proteins)) domain of this protein
The genetic loss of Rgs6 is associated with three phenotypes each individually associated with midbrain dopaminergic neuron neuron degeneration.
propose that inhibition of RGS6 might represent a viable means to reduce alcohol cravings and withdrawal in human patients, while simultaneously protecting the heart and liver from further damage upon relapse
RGS6 suppresses Ras-induced cellular transformation by facilitating Tip60 (show KAT5 Proteins)-mediated Dnmt1 (show DNMT1 Proteins) degradation and promoting apoptosis
Data indicate taht m2R-RGS6-IKACh pathway sets heart rate variability independently from the autonomic input.
Data indicate that genetic ablation of RGS6 expression resulted in anxiolytic and antidepressant behavior by enhancing signaling through the 5-HT1A receptor (show CC2D1A Proteins)-adenylyl cyclase (AC) axis.
RGS6-Gbeta5 (show GNB5 Proteins), but not RGS4 (show RGS4 Proteins), is the primary RGS (show PITX2 Proteins) modulator of parasympathetic HR regulation and SAN M2R-IKACh signaling in mice.
Spontaneous tumor formation was also seen in old female RGS6(-/-) but not in wild-type mice.
results identify RGS6 as an essential mediator of the pathogenic responses to doxorubicin in heart, and they argue that RGS6 inhibition offers a rational means to circumvent doxorubicin cardiotoxicity in human patients with cancer
establish RGS6 as a key component of GABA(B)R signaling
Regulator of G-protein signaling 6 (RGS6) is a previously unrecognized, but essential, negative regulator of parasympathetic activation in heart.
This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.
regulator of G-protein signaling 6
, regulator of G-protein signalling 6
, regulator of G-protein signaling 6-like
, GTPase activating protein