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a genome-wide linkage scan and regional association fine-mapping identified variants in the RYR3 gene as a quantitative trail locus for plasma adiponectin (show ADIPOQ PLURAL_@37961@) levels in Chinese population
Studies indicate that the ryanodine receptors (RyRs: RyR1 (show RYR1 Proteins), RyR2, RyR3) and inositol 1,4,5-trisphosphate receptors (IP3Rs: IP3R1 (show ITPR1 Proteins), IP3R2 (show ITPR2 Proteins), IP3R3 (show ITPR3 Proteins)) are the major Ca(2 (show CA2 Proteins)+) release channels (CRCs) on the endo/sarcoplasmic reticulum (ER/SR).
Data show that the common variant single-nucleotide polymorphism rs2229116 of the ryanodine receptor 3 gene (RYR3) was significantly associated with carotid intima-media thickness (cIMT).
SNPs within the RYR3 region were associated with subclinical atherosclerosis among HIV-infected women. Allelic heterogeneity observed across the three races suggests that the contribution of the RYR3 gene to CCA (show FBN2 Proteins) cIMT is complex.
rs877087 and rs2229116 of RYR3 gene are associated with atherosclerosis severity in Japanese.
a genetic interaction between the RYR3 and CACNA1C (show CACNA1C Proteins) genes explained variance in amyloid deposition above and beyond other major known risk factors for late-onset Alzheimer's disease
The findings reported here for the case-only analysis of the antihypertensive pharmacogenetic effect of RYR3 among 3058 CHD (show CHDH Proteins) cases .
the rectified RyR3 channel in open conformation may be regulated in situ by two cytosolic activating Ca(2 (show CA2 Proteins)+) sites
The current study suggests that the functional variant (rs1044129) in the miR (show MLXIP Proteins)-367 binding site of RYR3 may be a potential marker for prognosis in patients following curative surgery for colorectal cancer
RyR1 (show RYR1 Proteins), RyR2, and RyR3 transcripts were detected in human T cells, RyR1 (show RYR1 Proteins)/2 transcript levels increased, whereas those of RyR3 decreased after T cell activation.
Data indicate that TPPII can regulate sperm maturation by modulating intracellular Ca(2+) stores via the type 3 RyR.
knockdown of RyR1-3 expression in wild-type hippocampal neurons to levels comparable with the RyR protein reduction in presenilin-deficient hippocampal neurons mimics the defects exhibited in calcium homeostasis and presynaptic function
Silencing of RyR3 expression in 3T3-L1 preadipocytes resulted in up-regulated adiponectin (show ADIPOQ PLURAL_@37961@) promoter activity, enhanced adiponectin (show ADIPOQ PLURAL_@37961@) mRNA expression, and more adiponectin (show ADIPOQ PLURAL_@37961@) protein secreted into the medium.
Requirement of functional ryanodine receptor type 3 for astrocyte migration
Imperatoxin a enhances Ca(2 (show CA2 Proteins)+) release in developing skeletal muscle containing ryanodine receptor type 3.
ryanodine receptor-mediated calcium-induced calcium release is involved in the regulation of CRH (show CRH Proteins)-induced ACTH (show POMC Proteins) release.
as the stimulation of muscarinic receptor (show CHRM5 Proteins) in the airway smooth muscle increases, RyR1 (show RYR1 Proteins) and/or RyR3 also mediate the calcium response and thus bronchoconstriction
The short isoform of RYR3 controls calcium release through RYR2 in native smooth muscle cells.
relative levels of expression of RyR1 (show RYR1 Proteins) and RyR3 isoforms in developing mouse hindlimb and diaphragm muscles were determined
Physiologically voltage-controlled Ca(2 (show CA2 Proteins)+) sparks thus require a voltage sensor, a master junctional RyR1 (show RYR1 Proteins) channel that provides trigger Ca(2 (show CA2 Proteins)+), and a slave parajunctional RyR3 cohort
The protein encoded by this gene is a ryanodine receptor, which functions to release calcium from intracellular storage for use in many cellular processes. For example, the encoded protein is involved in skeletal muscle contraction by releasing calcium from the sarcoplasmic reticulum followed by depolarization of T-tubules. Two transcript variants encoding different isoforms have been found for this gene.
ryanodine receptor type 3
, brain ryanodine receptor
, ryanodine receptor 3
, Brain ryanodine receptor-calcium release channel
, Brain-type ryanodine receptor
, Type 3 ryanodine receptor
, brain ryanodine receptor-calcium release channel
, brain-type ryanodine receptor
, type 3 ryanodine receptor
, calcium release channel