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Human Smooth Muscle Actin ELISA Kit for Sandwich ELISA - ABIN364996
Liu, Tu, Deng, Liang: The S protein of hepatitis B virus promotes collagen type I expression in hepatic stellate cells by virtue of hepatocytes. in Biomedical reports 2014
Human Smooth Muscle Actin ELISA Kit for Sandwich ELISA - ABIN2014301
Xie, Wen, Yan, Wang, Wang, Chen, Li, Xu, Zhong, Shen, Chu: Toxoplasma gondii GRA15II effector-induced M1 cells ameliorate liver fibrosis in mice infected with Schistosomiasis japonica. in Cellular & molecular immunology 2016
Rat (Rattus) Smooth Muscle Actin ELISA Kit for Sandwich ELISA - ABIN578164
Graupp, Gruber, Weiss, Kiesler, Bachna-Rotter, Friedrich, Gugatschka: Establishing principles of macromolecular crowding for in vitro fibrosis research of the vocal fold lamina propria. in The Laryngoscope 2014
Data show that the locomotion and blebbing of the primordial germ cells (PGCs) required F-actin, myosin II activity and RhoA/Rho-associated protein kinase (ROCK) signaling.
During transition from the pluripotent stage towards the neural developmental stage, ACTA2 is differentially expressed in bipolar patient derived cells compared to control derived cells.
Two unrelated patients with the heterozygous R189H mutation in ACTA2 and complex congenital heart defects expands the cardiac phenotype of multisystemic smooth muscle dysfunction syndrome.
Cells in high glucose for 7 days showed a significant decrease in mRNA expression of CD31 (show HBA1 ELISA Kits) and VE-cadherin (show CDH5 ELISA Kits), and a significant increase in that of alpha-SMA (show SMN1 ELISA Kits) and collagen I.
ACTA2 is the isoform of contractile protein (show TNNT2 ELISA Kits) alpha-actin present in vascular smooth muscle cells (SMCs) throughout the arterial tree.4 Pathologic conditions in individuals with ACTA2 mutations show increased deposition of SMCs in the intimal arterial layer, leading to a decreased intraluminal diameter.4
Two novel actin alpha 2 mutations (N117I and L348R) were identified in each familial non-syndromatic thoracic aortic aneurysm proband separately, and an additional novel actin alpha 2 mutation (Y168N) was identified in one patient with sporadic non-syndromatic thoracic aortic aneurysm.
The R179H mutation has the potential to affect actin structure and function in both the contractile domain of the cell and the more dynamic cytoskeletal pool of actin, both of which are required for contraction.
site-directed mutagenesis revealed several basic amino acid residues in the intermolecular (R267) and intramolecular (K82 and R159) subdomains that are essential for Purbeta (show PURB ELISA Kits) transcriptional repressor function in Acta2 promoter-reporter assays. In keeping with their diminished Acta2 repressor activity in fibroblasts, purified Purbeta (show PURB ELISA Kits) variants containing an R267A mutation exhibited reduced binding affinity for purine-ric (show FXYD5 ELISA Kits)...
Data show that the expression profiles of three proteins: E-cadherin (show CDH1 ELISA Kits), Snail (show SNAI1 ELISA Kits), and alpha-smooth muscle actin (show ACTG2 ELISA Kits) were significantly different in extraprostatic extension prostate cancer (PCa (show FLVCR1 ELISA Kits)) compared with intra-prostatic tumour.
ACTA2 mutations are associated with structural disruption and functional impairment of contractile proteins, and predispose to a variety of diffuse vascular diseases including TAAD, CAD (show CAD ELISA Kits), ischemic strokes, and Moyamoya disease. Vascular SMCs are also implicated in vascular remodeling in both physiological and pathological conditions.
Parenchymal alphaSMA expression in hepatic tissue appeared to increase only among hepatitis C subjects with fibrosis 3-4.
Gremlin1 accelerates hepatic stellate cell activation through upregulation of TGF-B1, alpha-SMA (show SMN1 ELISA Kits), and COL1a1 (show COL1A1 ELISA Kits) expression in a liver fibrosis disease model.
Disruption of smooth muscle Acta2 increases reactive oxygen species levels, activates NF-kappaB (show NFKB1 ELISA Kits) signaling and increases AngII receptor type I a expression.
The expression levels of alpha-smooth muscle actin (show ACTG2 ELISA Kits) (alpha-SMA (show SMN1 ELISA Kits), a marker of fibroblast activation) in fibrotic livers were significantly higher than those in control livers.
this study identifies Rac1 as a downstream target for SMA (show SMN1 ELISA Kits) to inhibit smooth muscle cell proliferation and migration.
the coordinated up-regulations of desmin (show DES ELISA Kits) and alpha- actinin (show ACTN1 ELISA Kits) specifically in the early stage of diastolic heart failure mouse models indicate a novel myocardial response.
Alpha-smooth muscle actin (show ACTG2 ELISA Kits) protein (show ACTR3 ELISA Kits) and mRNA are enhanced from brain blood vessels in an Alzheimer's disease animal model.
Astragaloside can delay the renal fibrosis process in diabetic mice by influencing the TGF-beta (show TGFB1 ELISA Kits)/SMADS signaling pathway and down-regulating TGF-beta1 (show TGFB1 ELISA Kits), SMAD2 (show SMAD2 ELISA Kits)/3, and alpha-SMA (show SMN1 ELISA Kits) expression.
The increased expressions of the cartilage-associated proteins Collagen2 and alpha-SMA (show SMN1 ELISA Kits) during scleral chondrogenesis accompany myopia development.
Results suggest that the atypical motif asparaging-cysteine-systeine Asn(17)-Cys(18)-Cys(19) is crucial for the normal surface trafficking and function of hydroxycarboxylic acid receptor 2 protein hGPR109A.
TnT has a previously unrecognized role in forming the inactive state of regulated actin.
The terminal pointed end subunit is tilted (show OTOP1 ELISA Kits) towards the penultimate subunit, allowing specific and extra loop-to-loop inter-strand contacts between the two end subunits, which is not possible in other parts of the filament.
There was no significant change in the expression of TGF-beta(2 (show TGFB2 ELISA Kits)) and alpha-SMA (show SMN1 ELISA Kits) after laser-assisted intrastromal scanning.
The arrangement of actin subunits in an actin dimer assembled by tandem W domains resembles that of a long-pitch helix of the actin filament.
The distribution of laminin and alphaSMA in the testis and epididymis might point out to their roles in the male reproduction.
The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified.
, alpha smooth muscle actin
, actin, alpha 2, smooth muscle, aorta
, actin alpha cardiac 1
, actin, aortic smooth muscle
, vascular smooth muscle alpha-actin
, alpha-smooth muscle actin
, actin, aortic smooth muscle-like
, alpha-cardiac actin
, cell growth-inhibiting gene 46 protein
, actin, alpha, vascular smooth muscle
, alpha actin 2
, smooth muscle alpha-actin
, alpha actin